Atopy history and the genomics of wheezing after influenza vaccination in children 6–59 months of age

Miller, E. Kathryn; Dumitrescu, Logan; Cupp, Chelsea; Dorris, Stacy L.; Taylor, Sallee; Sparks, Robert; Fawkes, Diane; Frontiero, Virginia; Rezendes, Anne M.; Marchant, Colin D.; Edwards, Kathryn M.; Crawford, Dana C.

doi:10.1016/j.vaccine.2011.02.071

Cited by 11 publications

(5 citation statements)

References 42 publications

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“…The case of α-tocopherol induced narcolepsy is emblematic of the pivotal role played by genetic predisposition in the development of vaccine adverse reactions [100,132,133]. Other intriguing genetic correlations have been reported for specific vaccines and adjuvants, including post vaccine fever [101], wheezing [134] and seizures [135].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Pellegrino

Clementi

Radice

2015

Autoimmunity Reviews

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Section: Accepted Manuscriptmentioning

confidence: 99%

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Pellegrino

Clementi

Radice

2015

Autoimmunity Reviews

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“…LAIV4 is an intranasally administered vaccine that is very popular among parents and healthcare professionals due to the non-invasive route of administration. However, a diagnosis of asthma or a wheezing episode in the previous 12 months represents a contraindication for LAIV4 in children aged two to four years because of a reported higher incidence of wheezing in LAIV recipients compared with IIV recipients [ 250 , 251 ]. This contraindication has been questioned and many studies also demonstrated the vaccine’s safety in the population of preschool wheezers and severe asthmatic patients [ 252 , 253 , 254 ].…”

Section: Resultsmentioning

confidence: 99%

Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group

Grandinetti

Fainardi

Caffarelli

et al. 2022

JCM

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Wheezing at preschool age (i.e., before the age of six) is common, occurring in about 30% of children before the age of three. In terms of health care burden, preschool children with wheeze show double the rate of access to the emergency department and five times the rate of hospital admissions compared with school-age asthmatics. The consensus document aims to analyse the underlying mechanisms involved in the pathogenesis of preschool wheezing and define the risk factors (i.e., allergy, atopy, infection, bronchiolitis, genetics, indoor and outdoor pollution, tobacco smoke exposure, obesity, prematurity) and the protective factors (i.e., probiotics, breastfeeding, vitamin D, influenza vaccination, non-specific immunomodulators) associated with the development of the disease in the young child. A multidisciplinary panel of experts from the Emilia-Romagna Region, Italy, addressed twelve key questions regarding managing preschool wheezing. Clinical questions have been formulated by the expert panel using the PICO format (Patients, Intervention, Comparison, Outcomes). Systematic reviews have been conducted on PubMed to answer these specific questions and formulate recommendations. The GRADE approach has been used for each selected paper to assess the quality of the evidence and the degree of recommendations. Based on a panel of experts and extensive updated literature, this consensus document provides insight into the pathogenesis, risk and protective factors associated with the development and persistence of preschool wheezing. Undoubtedly, more research is needed to improve our understanding of the disease and confirm the associations between certain factors and the risk of wheezing in early life. In addition, preventive strategies must be promoted to avoid children’s exposure to risk factors that may permanently affect respiratory health.

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“…Immunogenetic factors may influence vaccine effectiveness and could contribute to vaccine adverse events as well. This has been evidenced from studies on influenza, MMR, smallpox, and yellow fever vaccines (28,43,45,46,48). Current data indicated minor side effects of mRNA and viral vector based vaccines, such as headache, fever, fatigue, and body aches.…”

Section: Genetics and Response To Sars-cov-2 Vaccinesmentioning

confidence: 95%

“…However, the field of adversomics is still relatively new compared to other fields and only a very few studies has been conducted so far ( Table 2 ). Additionally, multiple studies that looked into the underlying genetic factors in individuals experiencing adverse effects did not report any GWAS significant associations ( 45 ). This could be attributed to the small sample sizes, which reflects the infrequency of serious adverse vaccines or the complexity of such analysis.…”

Section: Genetics and Vaccine Adverse Eventsmentioning

confidence: 99%

Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents

et al. 2022

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Recent progress in genomics and bioinformatics technologies have allowed for the emergence of immunogenomics field. This intersection of immunology and genetics has broadened our understanding of how the immune system responds to infection and vaccination. While the immunogenetic basis of the huge clinical variability in response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is currently being extensively studied, the host genetic determinants of SARS-CoV-2 vaccines remain largely unknown. Previous reports evidenced that vaccines may not protect all populations or individuals equally, due to multiple host- and vaccine-specific factors. Several studies on vaccine response to measles, rubella, hepatitis B, smallpox, and influenza highlighted the contribution of genetic mutations or polymorphisms in modulating the innate and adaptive immunity following vaccination. Specifically, genetic variants in genes encoding virus receptors, antigen presentation, cytokine production, or related to immune cells activation and differentiation could influence how an individual responds to vaccination. Although such knowledge could be utilized to generate personalized vaccine strategies to optimize the vaccine response, studies in this filed are still scarce. Here, we briefly summarize the scientific literature related to the immunogenetic determinants of vaccine-induced immunity, highlighting the possible role of host genetics in response to SARS-CoV-2 vaccines as well.

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Atopy history and the genomics of wheezing after influenza vaccination in children 6–59 months of age

Cited by 11 publications

References 42 publications

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group

Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents

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