Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors

Carlsten, Chris; Dimich‐Ward, Helen; Ferguson, Alexander C.; Watson, Wade; Rousseau, Roxanne; DyBuncio, Anne; Becker, Allan B.; Chan‐Yeung, Moira

doi:10.1016/j.anai.2012.10.005

Cited by 95 publications

(80 citation statements)

References 30 publications

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“…6,23,28,31,44,45,48 The duration of AD persistence was significantly higher in females (median: 9.0 years; mean ± SE: 12.7 ± 0.2 years) compared with males (median: 7.0 years; mean±SE: 11.7 ± 0.2 years) (HR 1.15; 95% CI 1.04-1.27; P = .006) (Fig 2, E).…”

Section: Ad Persistence By Gendermentioning

confidence: 90%

“…After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender, 6,23,28,31,44,45,48 6 for allergen sensitization, 6,17,23,36,40,45 and 3 for baseline AD severity 17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1. …”

Section: Literature Searchmentioning

confidence: 99%

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Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

192

156

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Section: Ad Persistence By Gendermentioning

confidence: 90%

Section: Literature Searchmentioning

confidence: 99%

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

192

156

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“…Major allergic disorders in childhood, such as food allergies (FA), bronchial asthma (BA) and pollinosis develop one after another, referred to as the allergic march [1,2]. FA often develop in infants with atopic dermatitis (AD), and BA has a tendency to develop later in children who have or previously had FA and/or AD.…”

Section: Introductionmentioning

confidence: 99%

Close Positive Correlation between the Lymphocyte Response to Hen Egg White and House Dust Mites in Infants with Atopic Dermatitis

Kimura

Meguro

Ito

et al. 2015

Int Arch Allergy Immunol

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Background: It was recently hypothesized that food allergens sensitize infants with atopic dermatitis (AD) via the skin. If this is the case, an intimate positive correlation should be observed between immune responses to both food and indoor allergens. Methods: One hundred and seven infants with AD and 32 controls were enrolled. The proliferation of lymphocytes stimulated with hen egg white (EW) or house dust mite (HDM) allergens was measured by means of an allergen-specific lymphocyte stimulation test (ALST). Cytokine production was measured in 13 patients and 4 controls. Results: ALST responses for EW (EW-ALST) were significantly higher in AD infants than in control subjects (stimulation index: 7.98 vs. 2.54, p < 0.0001). HDM-ALST responses were also significantly higher in AD infants than in controls (stimulation index: 5.09 vs. 1.44, p < 0.0001). A significant positive correlation was seen between HDM-ALST and EW-ALST responses in AD infants aged 5-6 months (rs = 0.77, p < 0.000001). Serum levels of EW-specific IgE (EW-IgE) were significantly correlated with both EW-ALST (rs = 0.43, p < 0.05) and HDM-ALST levels (rs = 0.47, p < 0.05) in AD patients aged 3-4 months. Serum EW-IgE levels in AD infants were significantly correlated with the ratio of IL-4/IFN-γ production from lymphocytes stimulated with EW (rs = 0.62, p < 0.01) and with HDM (rs = 0.67, p < 0.005). Conclusions: This study describes the close positive correlation between EW- and HDM-specific immune responses in infants with AD. These results may support the hypothesis that both food and indoor allergens concurrently sensitize infants via the skin.

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“…The main dermatoses with the leading allergic component in pathogenesis and clinical course are atopic dermatitis, various forms of eczema, allergic contact dermatitis [1,2]. The study of the etiology and pathogenesis of these skin diseases, as well as a reasonable selection of their optimal treatment are extremely relevant problems of modern medicine [1,2].…”

mentioning

confidence: 99%

“…The study of the etiology and pathogenesis of these skin diseases, as well as a reasonable selection of their optimal treatment are extremely relevant problems of modern medicine [1,2]. Numerous studies showed the complex multifaceted nature of the violations on the part of different organs and systems in patients with allergic dermatitis [2][3][4].…”

mentioning

confidence: 99%

Chronic allergic skin diseases in men: the influence of age-related dishormonal status

Резніченко¹

2017

ZMJ

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The study of the etiology and pathogenesis of allergic skin diseases, as well as a reasonable selection of their optimal treatment are extremely relevant problems of modern medicine. Changes in the sex and gonadotropic hormones levels, which occur in patients with chronic allergic dermatoses and affect them, are studied insufficiently.The objective of this work was to study changes in levels of sex and gonadotropic hormones in patients with allergic dermatoses in older age groups and the development of effective methods of their treatment. Materials and Methods.Were examined 203 men: 36 healthy persons aged 25-44 years, 167 male aged 45-64 years (including 63 healthy males and 104 patients with chronic allergic dermatoses). The assessment of allergic dermatoses severity was conducted according to the SCORAD system. The evaluation of patients' life quality was performed by means of a DLQI questionnaire. The Aging Males Symptoms Scale was used. The concentration of testosterone, testosteron-binding globulin, follicle stimulating hormone, luteinizing hormone, prolactin were studied in blood serum by ELISA.Results. During the study it was found that male patients with chronic allergic dermatoses had significantly lower testosterone levels and significantly higher levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosteron-binding globulin in comparison with the group of healthy men of similar age. Additional use of drug on the basis of steroidal saponins in the complex therapy of male patients aged 45-64 years with chronic allergic dermatoses had a positive clinical effect, which manifested by reduction of SCORAD index, DLQI index, Aging Males Symptoms Scale index and also normalized the level of testosterone. Additional use of nootropic drug in this cohort of patients had positive clinical effect, which manifested by reduction of SCORAD index, DLQI index, Aging Males Symptoms Scale index and also normalized the levels of testosterone, follicle stimulating hormone, luteinizing hormone and prolactin. Conclusions.The obtained results indicate the existence of age-related dishormonal state in male patients aged 45-64 years with chronic allergic dermatoses. The results of investigation substantiate the feasibility of corrective measures in male patients with allergic chronic dermatoses, by the use of nootropic drug and drug on the basis of steroidal saponins.Хронічні алергічні захворювання шкіри у чоловіків: вплив вікового дисгормонального статусу Н. Ю. РезніченкоВивчення етіології та патогенезу алергічних захворювань шкіри, як і вибір оптимального лікування, являють собою надзви-чайно важливі проблеми сучасної медицини. Зміни рівнів статевих і гонадотропних гормонів, що відбуваються в пацієнтів із хронічними алергічними дерматозами та впливають на них, вивчені недостатньо.Мета роботи -вивчити зміни рівнів статевих і гонадотропних гормонів у пацієнтів з алергодерматозами старших вікових груп і розробити ефективні методи їх лікування.Матеріали та методи. Обстежили 203 чоловіки: 36 здорових осіб (2...

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Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors

Cited by 95 publications

References 30 publications

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Close Positive Correlation between the Lymphocyte Response to Hen Egg White and House Dust Mites in Infants with Atopic Dermatitis

Chronic allergic skin diseases in men: the influence of age-related dishormonal status

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