Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Abstract

Background-Previous studies found conflicting results about whether childhood atopic dermatitis (AD) persists into adulthood.

The Role of Epidermal Barrier Impairments in Atopic Dermatitis: Modern Concepts of Disease Pathogenesis

“…J. Kim и соавт. [4], обобщив резуль-таты 45 исследований, в которых участвовало более 110 тыс. пациентов из 15 стран, показали, что у детей старше 8 лет в 80% случаев уже отсутствовали симпто-мы атопического дерматита, и лишь менее чем у 5% признаки болезни сохранялись через 20 лет наблюде-ния.…”

“…пациентов из 15 стран, показали, что у детей старше 8 лет в 80% случаев уже отсутствовали симпто-мы атопического дерматита, и лишь менее чем у 5% признаки болезни сохранялись через 20 лет наблюде-ния. Вместе с тем у детей с дебютом атопического дер-матита до двухлетнего возраста отмечен более низкий риск хронизации дерматоза в отличие от пациентов, Обмен опытом у которых первые патологические проявления возникли в более старшем возрасте [4].…”

Atopic Dermatitis Progression: Evaluating Intervention Strategies

“…However, predicting which individuals will have persistent disease has not been possible. In a recently published metaanalysis of 45 studies from 15 countries (involving 110,651 patients, for a total of 434,992 patient-years), Kim and colleagues 14 found that three main factors were involved in the risk for persistence of AD into adulthood: (1) disease in childhood that persists for 10 years or more (compared to ≤5 years); (2) onset of AD later than 2 years of age; and (3) greater vs less severity of AD in childhood.…”

T helper type 2 signatures in atopic dermatitis

“…10 Atopic dermatitis is more frequent in childhood, especially in the first five years of life. 11,12 The prevalence or incidence of AD in the first five years of childhood is 10%-16.5% and is generally considered to be increasing worldwide, at least from the 1980s to early 2000s. [13][14][15] Most pediatric AD cases are mild-to-moderate in severity, with 84% of cases considered mild, 14% moderate, and only 2%…”

“…11 Children with moderate-to-severe AD at age 9-16 months are more likely to have persistent AD 6-12 years later compared to those with mild disease. 24 Fifty percent of subjects have at least one six-month symptom-/treatment-free period, but symptoms frequently recur until 20 years of age.…”