Chronic allergic skin diseases in men: the influence of age-related dishormonal status

Abstract

The study of the etiology and pathogenesis of allergic skin diseases, as well as a reasonable selection of their optimal treatment are extremely relevant problems of modern medicine. Changes in the sex and gonadotropic hormones levels, which occur in patients with chronic allergic dermatoses and affect them, are studied insufficiently.The objective of this work was to study changes in levels of sex and gonadotropic hormones in patients with allergic dermatoses in older age groups and the development of effective methods of their treatment. Materials and Methods.Were examined 203 men: 36 healthy persons aged 25-44 years, 167 male aged 45-64 years (including 63 healthy males and 104 patients with chronic allergic dermatoses). The assessment of allergic dermatoses severity was conducted according to the SCORAD system. The evaluation of patients' life quality was performed by means of a DLQI questionnaire. The Aging Males Symptoms Scale was used. The concentration of testosterone, testosteron-binding globulin, follicle stimulating hormone, luteinizing hormone, prolactin were studied in blood serum by ELISA.Results. During the study it was found that male patients with chronic allergic dermatoses had significantly lower testosterone levels and significantly higher levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosteron-binding globulin in comparison with the group of healthy men of similar age. Additional use of drug on the basis of steroidal saponins in the complex therapy of male patients aged 45-64 years with chronic allergic dermatoses had a positive clinical effect, which manifested by reduction of SCORAD index, DLQI index, Aging Males Symptoms Scale index and also normalized the level of testosterone. Additional use of nootropic drug in this cohort of patients had positive clinical effect, which manifested by reduction of SCORAD index, DLQI index, Aging Males Symptoms Scale index and also normalized the levels of testosterone, follicle stimulating hormone, luteinizing hormone and prolactin. Conclusions.The obtained results indicate the existence of age-related dishormonal state in male patients aged 45-64 years with chronic allergic dermatoses. The results of investigation substantiate the feasibility of corrective measures in male patients with allergic chronic dermatoses, by the use of nootropic drug and drug on the basis of steroidal saponins.Хронічні алергічні захворювання шкіри у чоловіків: вплив вікового дисгормонального статусу Н. Ю. РезніченкоВивчення етіології та патогенезу алергічних захворювань шкіри, як і вибір оптимального лікування, являють собою надзви-чайно важливі проблеми сучасної медицини. Зміни рівнів статевих і гонадотропних гормонів, що відбуваються в пацієнтів із хронічними алергічними дерматозами та впливають на них, вивчені недостатньо.Мета роботи -вивчити зміни рівнів статевих і гонадотропних гормонів у пацієнтів з алергодерматозами старших вікових груп і розробити ефективні методи їх лікування.Матеріали та методи. Обстежили 203 чоловіки: 36 здорових осіб (2...

Comparative study of the effectiveness of antihistamine preparations in the treatment of patients with atopic dermatitis

“…Atopic dermatitis is considered to be one of the main dermatoses, in the occurrence and development of which allergic component is the leading one [1][2][3]. The study of the etiology, pathogenesis and clinical features of atopic dermatitis, as well as the grounded choice of its optimal treatment, are extremely urgent problems of modern medicine [4][5][6]. The problem is associated with a high incidence of the disease, a constantly recurrent course, an increase in the number of trigger factors, an insufficient effectiveness of standard therapy, and the need for complex treatment with the recommendations of doctors of various specialties [1,5,7].…”