Atopic dermatitis from adolescence to adulthood in the <scp>TOACS</scp> cohort: prevalence, persistence and comorbidities

Mørtz, Charlotte G.; Andersen, Klaus Ejner; Dellgren, Christoffer; Barington, Torben; Bindslev‐Jensen, Carsten

doi:10.1111/all.12619

Cited by 224 publications

(187 citation statements)

References 48 publications

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“…6,23,28,31,44,45,48 The duration of AD persistence was significantly higher in females (median: 9.0 years; mean ± SE: 12.7 ± 0.2 years) compared with males (median: 7.0 years; mean±SE: 11.7 ± 0.2 years) (HR 1.15; 95% CI 1.04-1.27; P = .006) (Fig 2, E).…”

Section: Ad Persistence By Gendermentioning

confidence: 91%

“…After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender, 6,23,28,31,44,45,48 6 for allergen sensitization, 6,17,23,36,40,45 and 3 for baseline AD severity 17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1. …”

Section: Literature Searchmentioning

confidence: 99%

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Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

205

156

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Section: Ad Persistence By Gendermentioning

confidence: 91%

Section: Literature Searchmentioning

confidence: 99%

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

205

156

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“…In a recent study carried out in China, investigators reported that 77.5% of patients presented with AD after age 12 and suggested that late-onset AD is quite common [13]. Between 9% and 47% of cases of AD also appear de novo in adults (≥18 years), although the most widely accepted proportion is 9%-24.5% [2,5,15]. Among adults who develop AD, peak incidence occurs at age 20-40 years [20], although the disease does not completely subside after that.…”

Section: Epidemiologymentioning

confidence: 99%

“…The disease progresses with a chronic recurrent course before disappearing some time before puberty. However, it may persist into adulthood or present de novo during that period [1][2][3]. Bannister and Freeman [4] recently introduced the term adult-onset atopic dermatitis.…”

Section: Introductionmentioning

confidence: 99%

Atopic Dermatitis in Adults: A Diagnostic Challenge

Salvador¹,

Romero‐Pérez²,

Encabo-Durán³

2017

J Investig Allergol Clin Immunol

143

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Atopic dermatitis (AD) has a prevalence of 1%-3% in adults. Adult-onset AD has only been defined recently, and lack of familiarity with this condition and confusion regarding the appropriate terminology persist. AD may first appear in childhood or de novo in adults and is characterized by pronounced clinical heterogeneity. The disease often deviates from the classic pattern of flexural dermatitis, and there are forms of presentation that are specific to adults, such as head-and-neck dermatitis, chronic eczema of the hands, multiple areas of lichenification, or prurigo lesions. Although diagnosis is clinical, adult-onset AD frequently does not fit the traditional diagnostic criteria for the disease, which were developed for children. Thus, AD is often a diagnosis of exclusion, especially in de novo cases. Additional diagnostic tests, such as the patch test, prick test, skin biopsy, or blood test, are usually necessary to rule out other diseases or other types of eczema appearing concomitantly with AD. This article presents an update of the different forms of clinical presentation for AD in adults along with a proposed diagnostic approach, as new treatments will appear in the near future and many patients will not be able to benefit from them unless they are properly diagnosed. Key words: Atopic dermatitis. Adult. Diagnosis. Patch testing. Prick testing. ResumenLa dermatitis atópica (DA) en el adulto tiene una prevalencia del 1-3%. Es una entidad de reciente acuñamiento, que no todo el mundo conoce y sobre la que existe una gran confusión terminológica. Puede iniciarse en la infancia o presentarse de "novo" en el adulto. Presenta una gran heterogeneidad clínica y con frecuencia no sigue el patrón clásico de dermatitis flexural. Además, existen formas de presentación más propias de adulto como son la dermatitis de la cabeza y el cuello, eczema crónico de manos, áreas de liquenificación múltiple o lesiones de prurigo. Aunque su diagnóstico es clínico, muchas veces la DA del adulto no cumple los criterios diagnósticos "clásicos" de DA, pues están pensados para niños. Por eso, suele ser un diagnóstico de exclusión, sobre todo los casos de "novo". Suele precisar de la realización de pruebas diagnósticas para descartar otras enfermedades distintas u otro tipo de eczema sobreañadido a la DA. Las pruebas diagnósticas que pueden resultar útiles para ello son: pruebas epicutáneas, prick test, biopsia cutánea y una analítica sanguínea. Realizamos una actualización de las distintas formas de presentación clínica de la DA del adulto y establecemos unas pautas para llegar a su diagnóstico, pues en un futuro inmediato, con la aparición de nuevos tratamientos, muchos de estos pacientes no podrán beneficiarse de los mismos por no estar adecuadamente diagnosticados. Palabras clave: Dermatitis atópica. Adulto. Diagnóstico. Pruebas epicutáneas. Prick test.

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“…Наше теперішнє розуміння про атопіч-ний дерматит (АД) різко змінилося на протязі останніх років, головним чином через значний про-грес у епідеміології та генетиці, величезний прорив в розумінні концепції атопічного маршу [1], а також розкриття нових аспектів щодо анамнезу хвороби [2,3] та вивчення форм АД, які персистують на протязі всього життя [4,5].…”

Section: C-159t поліморфізм гену Cd14 та цитокіновий профіль при атопunclassified

C-159T Polymorphism of CD14 Gene and Citokine Profile at Atopic Dermatite in Adults

Litus¹,

Derkach²,

Litus³

2018

Ukr. ž. med. bìol. sportu

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Litus O. I., Derkach N. V., Litus V. I. Abstract. The aim of the study was to research polymorphism of the C-159T gene of the CD14 receptor gene and the levels of serum cytokines in exogenous and endogenous atopic dermatitis in adults.Materials and methods. The study included 96 adult patients with atopic dermatitis. The control group consisted of 90 healthy volunteers. The polymerase chain reaction with electrophoretic detection was used to analyze the polymorphism of the gene. The content of total IgE and cytokines of TNF-α, IL-2, γ-IF, IL-4, IL-5, IL-10, TFR-β in serum was determined by ELISA.Results and Discussion. It was found that the prevalence of the CC genotype leads to an increased risk of developing exogenous atopic dermatitis, which is associated with a high level of total IgE, IL-5 and low IL-10, TGF-β at a given genotype. At the same time, the reduction in the risk of development of both endogenous and exogenous atopic dermatitis is associated with prevalence in the population of genotypes CT and TT. Reducing the risk of atopic dermatitis in the presence of the T allele can be explained by the low concentration of IL-5 and high IL-10, TGF-β in comparison with the homozygous genotype of the CC.Conclusions. The risk of development of atopic dermatitis is authentically increased (Р = 0,033) at a prevalence allele with polymorphic site CD14 of a receptor. In the presence of a genotype of CC in patients with exogenous atopic dermatitis high levels of the general IgE, IL-5 and low IL-10, TFR-β in comparison with other genotypes are characteristic.Decreasing the risk of developing exogenous atopic dermatitis endogenous is associated with a prevalence in population of genotypes of СT and TT. The risk of developing atopic dermatitis in the presence allele is reduced. The T is characterized by low concentration of IL-5 and high IL-10, TFR-β in comparison with a homozygous genotype of CC.The risk of atopic dermatitis development is increased with the prevalence of allele C and decreased with allele T of the polymorphic region C-159T of the CD14 receptor.

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Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities

Cited by 224 publications

References 48 publications

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Atopic Dermatitis in Adults: A Diagnostic Challenge

C-159T Polymorphism of CD14 Gene and Citokine Profile at Atopic Dermatite in Adults

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