Atopic dermatitis and early childhood caries: Results of the GUSTO study

Kalhan, Tosha Ashish; Kalhan, Ashish Chetan; Kramer, Michael S.; Karunakaran, Bindu; Lam, Carolina Un; Bever, Hugo Van; Goh, Angela; Chong, Yap Seng; Lee, Bee Wah; Gluckman, Peter D.; Kwek, Kenneth; Saw, Seang Mei; Godfrey, Keith M.; Hsu, Chin‐Ying Stephen

doi:10.1016/j.jaci.2016.10.038

Cited by 16 publications

(29 citation statements)

References 9 publications

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“…The Growing Up Towards Health Outcomes (GUSTO) study looked longitudinally at whether the occurrence of AD during the first year of life had an association with the risk of early childhood caries at ages 2 and 3 years. 28 In children with AD and a positive skin test result, a greater risk of caries was associated at both 2 and 3 years of age. These results suggest that molecular changes in skin composition and risk of skin disease can also be extrapolated to other damaged surface areas, particularly teeth.…”

Section: Barrier Disruptionmentioning

confidence: 96%

Advances in atopic dermatitis in 2017

Kennedy

Heimall

Spergel

2018

Journal of Allergy and Clinical Immunology

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Section: Barrier Disruptionmentioning

confidence: 96%

Advances in atopic dermatitis in 2017

Kennedy

Heimall

Spergel

2018

Journal of Allergy and Clinical Immunology

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“…Data are expressed as mean ± SD or % ± SE. www.nature.com/scientificreports/ test (SPT) results showed higher OR value than total reported-AD or AD with negative SPT results, which may exclude simple rashes or other skin condition other than true AD by combining SPT results 22 . Since our study investigated self-reported diseases only, there is a possibility that skin conditions other than AD may be included, resulting lower OR values of AD than GUSTO study which present OR value up to 3 in AD with positive SPT.…”

Section: Discussionmentioning

confidence: 99%

“…The different results from our study may arise from objective oral findings which is more strict outcomes than subjective oral symptoms. However, the GUSTO birth cohort study, which also included oral examination, found that a risk of early childhood caries (ECC), a chronic diet-mediated infectious oral disease at 2 or 3 years of age, was associated with the development of AD within the first year of birth 22 . This birth cohort study suggests the presence of a common pathologic mechanisms between AD and ECC, which is ectodermal defects during tissue development 22 .…”

Section: Discussionmentioning

confidence: 99%

“…However, the GUSTO birth cohort study, which also included oral examination, found that a risk of early childhood caries (ECC), a chronic diet-mediated infectious oral disease at 2 or 3 years of age, was associated with the development of AD within the first year of birth 22 . This birth cohort study suggests the presence of a common pathologic mechanisms between AD and ECC, which is ectodermal defects during tissue development 22 . AD with positive skin prick test (SPT) results showed higher OR value than total reported-AD or AD with negative SPT results, which may exclude simple rashes or other skin condition other than true AD by combining SPT results 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the pathomechanism of ECC also includes some structural defects in tooth formative stages caused by genetic mutation, leading to increased susceptibility to dental caries 26 . For example, the distal-less homeobox (Dlx-3) gene is important for both enamel formation and epidermal differentiation, and some polymorphisms of genes, such as mannose-binding lectin 2 (MBL2) and toll-like receptor 2 (TLR2), are associated with both ECC and AD 22 , 27 . In addition, FLG, a key structural protein involved in barrier function, is expressed not only in the epidermis but also in the human oral mucosa 15 , which may cause more infections in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

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Identification of oral symptoms associated with atopic dermatitis in adolescents: Results from the Korea national representative survey 2009–2017

Shim

Yang

2020

Sci Rep

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The relationship between oral health and atopic dermatitis (AD) remains unclear. Here we investigated the association between oral health status and AD using data from 634,299 subjects in the Korean Youth Risk Behavior Survey (KYRBS). Participants with oral symptoms were defined as those with any of following: sensitive teeth, toothache, bleeding gums or gum pain, and dry mouth. Current AD was determined by the question if participant had been diagnosed with AD from doctor within the past 12 months. We estimated the odds ratio (OR) for AD diagnosis according to the presence of oral symptoms. The OR for current AD, which is a dependent variable, was significantly increased in participants with oral symptoms, which are independent variables, in an adjusted model (OR, 1.27; 95% confidence interval [CI], 1.26–1.29; P < 0.001). In detailed analyses, all four oral symptoms were significantly associated with AD diagnosis: sensitive teeth (OR, 1.21; CI, 1.19–1.23; P < 0.001), bad breath (OR, 1.18; CI, 1.17–1.20; P < 0.001), toothache (OR, 1.18; CI, 1.16–1.20; P < 0.001), and bleeding gums (OR, 1.14; CI, 1.12–1.16; P < 0.001). In the presence of oral symptoms, the ORs for having two or more allergic diseases (AD, allergic rhinitis, and/or asthma) were higher than that of AD alone. In this study, oral symptoms appeared to be associated with AD in Korean adolescences.

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Systematic exploration of eczema‐associated paediatric diseases in a Chinese population of millions: A retrospective observation study

Zheng

Yang

Feng

et al. 2023

Clinical & Translational All

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Background Eczema is the most common form of dermatitis and also the starting point of atopic march. Although many eczema‐associated allergic and immunologic disorders have been studied, there remains a gap in the systematic quantitative knowledge regarding the relationships between all childhood disorders and eczema. This study aimed to systematically explore eczema‐associated childhood diseases using a real‐world, long‐term clinical dataset generated from millions of children in China. Methods Data were collected at 8,907,735 outpatient healthcare visits from 2,592,147 children between January 1, 2013, and August 15, 2019, at the largest comprehensive pediatric medical center in Zhejiang Province of China. The period prevalence differences in various pediatric diseases between children with and without eczema were used to test the independence of various pediatric disorders and eczema using Fisher's exact test. Bonferroni correction was used to adjust the p value in multiple testing. Odds ratio >2 with 95% confidence interval not including 1 and adjusted p < 0.05 was used to identify eczema‐associated diseases. Results Overall, 234 pediatric disorders were identified from more than 6000 different pediatric disorders. An interactive eczema‐associated disease map that has related quantitative epidemiological features called ADmap was published at http://pedmap.nbscn.org/admap . Thirty‐six of these disease associations have not been reported in previous studies. Conclusion This systematic exploratory study confirmed the associations of many well‐known diseases with eczema in Chinese children and also identified some novel and interesting associations. These results are valuable for the development of a comprehensive approach to the management of eczema in childhood.

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Atopic dermatitis and early childhood caries: Results of the GUSTO study

Cited by 16 publications

References 9 publications

Advances in atopic dermatitis in 2017

Advances in atopic dermatitis in 2017

Identification of oral symptoms associated with atopic dermatitis in adolescents: Results from the Korea national representative survey 2009–2017

Systematic exploration of eczema‐associated paediatric diseases in a Chinese population of millions: A retrospective observation study

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