Atmospheric Pressure Microwave Plasma Torch for Biomedical Applications

Tsonev, Ivan; Atanasov, Nikolai; Atanasova, Gabriela; Krčma, František; Bogdanov, Todor

doi:10.1615/plasmamed.2019028816

Cited by 3 publications

(3 citation statements)

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“…For all experiments, we used a surface-wave discharge (SWD) in argon at atmospheric pressure. [8][9][10][11] The experimental setup is schematically presented in Fig. 1.…”

Section: Plasma Sourcementioning

confidence: 99%

Effect of Plasma-Activated Medium and Water on Replication and Extracellular Virions of Herpes Simplex Virus-1

et al. 2020

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We use a surface-wave sustained discharge (SWD) in argon at atmospheric pressure (using a plasma torch) in these experiments. The plasma torch is sustained using a 2.45-GHz electromagnetic wave with applied microwave powers of 13, 15, and 20 W. At these discharge conditions, the length of the plasma torch outside of the quartz tube is ~1-1.5 cm, and the gas plasma temperature does not exceed 40°C. This allows direct treatment of samples using the active zone of the discharge. In the cytotoxicity study, only two of the experimental settings achieve up to 50% survival of the cell monolayer after adding plasma-treated medium. Examining the effect of the plasma torch treatment media on herpes simplex virus-1 replication, we found that none of the applied experimental assays show significant protection on the cell monolayer. In a study of the virucidal action of a plasma-treated viral suspension diluted with sterile water at a ratio of 1:2 that was treated for 300 s at 13-W wave power, a decrease in the viral sample titer occurred unlike in the 1.67 log 10 control. Using optical emission spectroscopy, we found that OH intensity increases at the contact point between plasma and the water surface. Intensity of NO-γ also increases to the contact point with applied power. We also monitored the amount of peroxide radicals in plasma-treated water and nutrient medium in the presence of lucigenin.

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“…For all experiments, we used a surface-wave discharge (SWD) in argon at atmospheric pressure. [8][9][10][11] The experimental setup is schematically presented in Fig. 1.…”

Section: Plasma Sourcementioning

confidence: 99%

Effect of Plasma-Activated Medium and Water on Replication and Extracellular Virions of Herpes Simplex Virus-1

et al. 2020

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“…Artificial plasma is maintained at atmospheric pressure and near ambient temperature, owing to which it is known as CAP or non-thermal plasma; thus, this form of plasma can have biological applications without causing thermal damage [ 8 ]. Especially, cold atmospheric microwave plasma (CAMP) device used in this study was driven by continuous microwaves, eliciting biological responses more effectively even at low temperature when compared to conventional CAP methods using other energy sources [ 12 13 14 ].…”

Section: Introductionmentioning

confidence: 99%

Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

et al. 2023

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Background Cold atmospheric plasma is a novel innovative approach for wound care, and it is currently underrepresented in veterinary medicine. Objectives To investigate the efficacy and safety of using cold atmospheric microwave plasma (CAMP) as an adjunct therapy for wound healing in dogs and cats. Methods Wound healing outcomes were retrospectively analyzed using clinical records of client-owned dogs and cats who were first managed through standard wound care alone (pre-CAMP period) and subsequently via CAMP therapy (CAMP period). The degree of wound healing was estimated based on wound size and a modified wound scoring system. Results Of the 27 acute and chronic wounds included in the analysis, 81.48% showed complete healing after the administration of CAMP as an adjunct therapy to standard care. Most wounds achieved complete healing in < 5 weeks. Compared with the pre-CAMP period, the rate of wound healing significantly increased every week in the CAMP period in terms of in wound size (first week, p < 0.001; second week, p = 0.012; third week, p < 0.001) and wound score (first week, p < 0.001; second week, p < 0.001; third week, p = 0.001). No adverse events were noted except for mild discomfort and transient erythema. Conclusions CAMP is a well-tolerated therapeutic option with immense potential to support the treatment of wounds of diverse etiology in small animal practice. Further research is warranted to establish specific criteria for CAMP treatment according to wound characteristics.

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“…Due to this fact, in an MW-induced discharge, the radicals are present at a high density, thereby contributing to a raised level of fragmentation of the introduced monomer while maintaining room temperature. The plasma torch length can be varied by gas flow and supplied energy [22] and the monomer can be mixed with plasma at different positions with respect to the end of an active discharge. The high radical density in an MW-induced discharge is very advantageous as a high rate of chemical dissociation accompanied by subsequent recombination processes is a crucial reaction for thin film deposition.…”

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confidence: 99%

Atmospheric Pressure Microwave Plasma Jet for Organic Thin Film Deposition

et al. 2020

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In this work, the potential of a microwave (MW)-induced atmospheric pressure plasma jet (APPJ) in film deposition of styrene and methyl methacrylate (MMA) precursors is investigated. Plasma properties during the deposition and resultant coating characteristics are studied. Optical emission spectroscopy (OES) results indicate a higher degree of monomer dissociation in the APPJ with increasing power and a carrier gas flow rate of up to 250 standard cubic centimeters per minute (sccm). Computational fluid dynamic (CFD) simulations demonstrate non-uniform monomer distribution near the substrate and the dependency of the deposition area on the monomer-containing gas flow rate. A non-homogeneous surface morphology and topography of the deposited coatings is also observed using atomic force microscopy (AFM) and SEM. Coating chemical analysis and wettability are studied by XPS and water contact angle (WCA), respectively. A lower monomer flow rate was found to result in a higher C–O/C–C ratio and a higher wettability of the deposited coatings.

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Atmospheric Pressure Microwave Plasma Torch for Biomedical Applications

Cited by 3 publications

References 1 publication

Effect of Plasma-Activated Medium and Water on Replication and Extracellular Virions of Herpes Simplex Virus-1

Effect of Plasma-Activated Medium and Water on Replication and Extracellular Virions of Herpes Simplex Virus-1

Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

Atmospheric Pressure Microwave Plasma Jet for Organic Thin Film Deposition

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