Atividades biológicas de Miconia spp. Ruiz &amp; Pavon (Melastomataceae Juss.)

Chemical composition of the essential oils and extracts and the antimicrobial activity of Miconia minutiflora were investigated. The flavanone glycosides, pinocembroside and pinocembrin-7-O-[4″,6″-HHDP]-β-D-glucose, were identified, along with other compounds that belong mainly to the triterpene class, besides the phenolics, gallic acid and methyl gallate. Sesquiterpenes and monoterpenes were the major compounds identified from the essential oils. Screening for antimicrobial activity from the methanolic extract of the leaves showed that the MIC and MMC values against the tested microorganisms ranged from 0.625 to 5 mg·mL−1 and that the extract was active against microorganisms, Staphyloccocus aureus, Escherichia coli, and Bacillus cereus.

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Flavanone Glycosides, Triterpenes, Volatile Compounds and Antimicrobial Activity of Miconia minutiflora (Bonpl.) DC. (Melastomataceae)

Ferreira

Cascaes

Santos

et al. 2022

Molecules

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The Genus Miconia Ruiz & Pav. (Melastomataceae): Ethnomedicinal Uses, Pharmacology, and Phytochemistry

et al. 2022

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Species of the genus Miconia are used in traditional medicine for the treatment of diseases, such as pain, throat infections, fever, and cold, and they used as depuratives, diuretics, and sedatives. This work reviewed studies carried out with Miconia species, highlighting its ethnomedicinal uses and pharmacological and phytochemical potential. This information was collected in the main platforms of scientific research (PubMed, Scopus, and Web of Science). Our findings show that some of the traditional uses of Miconia are corroborated by biological and/or pharmacological assays, which demonstrated, among other properties, anti-inflammatory, analgesic, antimutagenic, antiparasitic, antioxidant, cytotoxic, and antimicrobial activities. A total of 148 chemical compounds were identified in Miconia species, with phenolic compounds being the main constituents found in the species of this genus. Such phytochemical investigations have demonstrated the potential of species belonging to this genus as a source of bioactive substances, thus reinforcing their medicinal and pharmacological importance.

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Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)

Bomfim¹,

Santos²,

Carneiro³

et al. 2020

J. Med. Plants Res.

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The resistance of microorganisms to current antimicrobials, and the deleterious effects caused by the excessive free radical manufacturing in the human body and their relationship with increasing global incidence of cancer, has led to a continuous search for new chemical agents that can contribute to the fight against these ills. The objective of the present work was to evaluate the antimicrobial, antioxidant and cytotoxic activities and determine the chemical profile of ethyl acetate extract of ten species of the family Melastomataceae. Antimicrobial activity was assessed by the methods of disk diffusion in agar and microdilution in broth (MIC-µg/mL). Antioxidant activity was measured by DPPH free radical capture assay while toxicity was evaluated with Artemia salina Leach. Cytoxicity was evaluated by in vitro tests with THP-1-cells. Identification of the classes of metabolites was performed using chemical reagents, while quantification of total phenols (EGA/g) and total flavonoids (EQ/g) was done by spectrophotometry. The extract of Clidemia capitellata exhibited activity against Micrococcus luteus with MIC = 62.5-μg/mL. The extract of C. hirta had the highest sequestering activity of DPPH free radicals (63.54-%). The toxicological assay revealed high toxicity for Miconia alborufescens extract (CL 50 61.6-μg/mL). Cytotoxic activity of extracts for THP-1-cells was observed through visualization of apoptotic bodies and cell death. Phytochemical analysis detected the presence of condensed tannins, terpenes, steroids and polyphenols, and the absence of alkaloids. The assays performed provided promising results, suggesting the continuation of new chemical-pharmacological evaluations and the isolation of the active principle of the extracts.

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Atividades biológicas de Miconia spp. Ruiz & Pavon (Melastomataceae Juss.)

Cited by 3 publications

References 3 publications

Flavanone Glycosides, Triterpenes, Volatile Compounds and Antimicrobial Activity of Miconia minutiflora (Bonpl.) DC. (Melastomataceae)

Flavanone Glycosides, Triterpenes, Volatile Compounds and Antimicrobial Activity of Miconia minutiflora (Bonpl.) DC. (Melastomataceae)

The Genus Miconia Ruiz & Pav. (Melastomataceae): Ethnomedicinal Uses, Pharmacology, and Phytochemistry

Antimicrobial, antioxidant and cytotoxic activites and chemical profile of species of Miconia Ruiz Pav., Clidemia D. Don and Tibouchina Aubl. (Melastomataceae)

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