The resistance of microorganisms to current antimicrobials, and the deleterious effects caused by the excessive free radical manufacturing in the human body and their relationship with increasing global incidence of cancer, has led to a continuous search for new chemical agents that can contribute to the fight against these ills. The objective of the present work was to evaluate the antimicrobial, antioxidant and cytotoxic activities and determine the chemical profile of ethyl acetate extract of ten species of the family Melastomataceae. Antimicrobial activity was assessed by the methods of disk diffusion in agar and microdilution in broth (MIC-µg/mL). Antioxidant activity was measured by DPPH free radical capture assay while toxicity was evaluated with Artemia salina Leach. Cytoxicity was evaluated by in vitro tests with THP-1-cells. Identification of the classes of metabolites was performed using chemical reagents, while quantification of total phenols (EGA/g) and total flavonoids (EQ/g) was done by spectrophotometry. The extract of Clidemia capitellata exhibited activity against Micrococcus luteus with MIC = 62.5-μg/mL. The extract of C. hirta had the highest sequestering activity of DPPH free radicals (63.54-%). The toxicological assay revealed high toxicity for Miconia alborufescens extract (CL 50 61.6-μg/mL). Cytotoxic activity of extracts for THP-1-cells was observed through visualization of apoptotic bodies and cell death. Phytochemical analysis detected the presence of condensed tannins, terpenes, steroids and polyphenols, and the absence of alkaloids. The assays performed provided promising results, suggesting the continuation of new chemical-pharmacological evaluations and the isolation of the active principle of the extracts.

Objective: to analyze the influence of sociodemographic variables, prison context, religiosity, and symptoms of depression on the presence of suicidal thinking in a population deprived of liberty. Method: a cross-sectional study with a quantitative approach, conducted with 228 participants, based on a sociodemographic questionnaire, on the prison context, and on the presence of suicidal thinking, from the Duke Religiosity Scale and the Depression, Anxiety and Stress Scale (DASS-21). Results: the variables that showed a statistically significant correlation were the following: female gender, not having a partner, working inside the penitentiary, being a primary defendant and using controlled medication, and females are 7.2 times more likely to present suicidal thinking, for each point more in the depression score, increases by 21% in the chances and not having a partner increases the chances of thinking about suicide by three times. Although the scores of religiosity were high, they did not present a statistically significant correlation with the presence of suicidal thinking. Conclusion: the prison context is complex and contains peculiarities that cause the involvement of mental health problems, as well as self-harming thoughts. Considering the relevance of the subject at issue, this work stands out in view of the scarce scientific production on the subject.

Trata-se de um relato de experiência no cuidado a uma paciente com o diagnóstico médico de doença arterial obstrutiva periférica acompanhada pelo Ambulatório de Feridas, projeto desenvolvido por uma Residência Integrada Multiprofissional em Saúde do interior de Minas Gerais. A paciente necessitou de acompanhamento por apresentar gangrena em pododáctilo 1º, 2° e 3° e úlcera em dorso do pé direito. Foram traçados os diagnósticos de enfermagem, para que fossem estabelecidas as devidas intervenções, sendo os diagnósticos: perfusão tissular periférica ineficaz, mobilidade física prejudicada, risco de infecção e dor aguda. Contudo, evidenciou-se a importância da Sistematização da Assistência de Enfermagem, uma ferramenta essencial para o desempenho de intervenções e de gerenciamento desse cuidado favorecendo a atuação do enfermeiro em uma abordagem integral além de fomentar outras investigações.

RESUMO: O objetivo deste estudo foi comparar as condições de saúde e lazer dos idosos diabéticos com e sem indicativo de depressão. Foram entrevistados 104 idosos diabéticos da zona rural de Uberaba-Minas Gerais, em 2011, utilizando-se os instrumentos Escala de Depressão Geriátrica Abreviada e semiestruturado, baseado no Olders Americans Resoucers and Services. Realizou-se análise descritiva e teste quiquadrado (p<0,05). A maioria, em ambos os grupos, era do sexo feminino, faixa etária entre 60-70 anos, moravam com o esposo ou companheiro, de 4-8 anos de estudo e renda de até um salário mínimo. Os idosos diabéticos com indicativo de depressão apresentaram, proporcionalmente, pior autopercepção da saúde, mais complicações relacionadas ao diabetes, maior uso de medicamentos combinados e insulina. Evidencia-se a necessidade de ações de saúde direcionadas ao monitoramento dos idosos diabéticos com indicativo de depressão visando estabelecimento de diagnóstico e acompanhamento para minimizar o impacto da doença no seu cotidiano. Palavras-Chave: Idoso; diabetes mellitus; população rural; depressão.