ATIVIDADE DO EXTRATO, FRAÇÕES E SUBSTÂNCIAS ISOLADAS DAS CASCAS DE Geissospermum vellosii ALLEMÃO (APOCYNACEAE) SOBRE Artemia salina LEACH

Abstract

RESUMO:O extrato, frações e substâncias isoladas das cascas de G. vellosii foram submetidos ao teste de bioatividade sobre A. salina. Os dados foram analisados pelo método Probitos e determinados os valores de DL 50 e 95% de intervalos de confiança. As amostras foram consideradas ativas quando DL 50 < 1000 µg.mL ABSTRACT:The extract, fractions and isolated substances of the barks from G. vellosii were submitted to the bioactivity test on A. salina. The data were analyzed by the Probitos' method and certain the values of DL 50 and 95% of trust intervals. The samples were considered active when DL 50 <1000 µg.mL , respectively. The results demonstrate the biotechnological potential of the species, because according to literature this bioessay can be used as previous evaluation of possible antitumoral activity.

Ethnopharmacological review, phytochemistry and bioactivity of the genus Geissospermum (Apocynaceae)

“…The MIC of the methanol/water fraction was 0.63 mg/mL for S. aureus, 0.63 mg/mL for S. mutans, and 0.63 mg/mL for C. albicans. Dias (2012) carried out a phytochemical and biological study of the ethanol extract, fractions and isolated constituents from the bark of G. vellosii, in which the compounds lupeol, sesamin, aspidospermine and a fraction (F14) were identified as a mixture of sesamin and aspidospermine. Antibacterial activity was tested by disk diffusion, MIC, and bioautography.…”

“…Studies with isolated indole alkaloids, extracts and fractions of different parts of Geissospermum spp. have reported antitumor pharmacological (Bastos, 2017;Bemis et al, 2009;Chang et al, 2014;Liu et al, 2019;Sajkowska-Kozielewicz et al, 2016;Yeh et al, 2019;Yu and Chen, 2014), antinociceptive, anti-inflammatory (Lima et al, 2016;Werner et al, 2009), anticholinesterase (Araújo et al, 2011;Lima et al, 2020Lima et al, , 2009, antileishmania, antitrypanosoma(da Silva e Silva et al, 2019;Reina et al, 2012), anti-HIV (Beljanski, 2005), antimicrobial (Camargo, 2011;Correia et al, 2008;Dias, 2012;Saraiva, 2012), cardiovascular (Martins, 2010;Morais, 2012), antioxidant (Sajkowska-Kozielewicz et al, 2016), andantimalarial (Bertania et al, 2005;Camargo, 2011;Mbeunkui et al, 2012;Muñoz et al, 2000;Oliveira, 2018;Steele et al, 2002). This review aims to update the ethnopharmacology, the phytochemistry and the biological activities of Geissospermum species described in the literature in order to contribute to the knowledge of bioactive compounds of therapeutic interest and establish directions for future research with this genus.…”