Atividade da 6-fosfogliconato desidrogenase em deficientes de glicose-6-fosfato desidrogenase

Nicolielo, Daniela B.; Ferreira, Rosecler I.P.; Leite, Amauri Antiquera

doi:10.1590/s1516-84842006000200014

Cited by 5 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies have also reported the frequency of G6PD deficiency ranging from 2 to 3% in the Brazilian population. (6)(7)(8)(9)(10)(11) Thus these data suggest that 6 million Brazilians have G6PD deficiency and that 1% of infants had episodes of jaundice to varying degrees associated to G6PD deficiency; 1.9 million Brazilians ran the risk of severe neonatal jaundice with a risk of kernicterus.…”

Section: Neonatal Jaundice and Glucose-6-phosphate Dehydrogenasementioning

confidence: 88%

Icterícia neonatal e deficiência de glicose-6-fosfato desidrogenase

Leite¹

2010

Rev. Bras. Hematol. Hemoter.

View full text Add to dashboard Cite

Glucose -6-phosphate Analysis of fatty acids in human plasma Scientific commentaries / Comentários científicos Rev Bras Hematol Hemoter. 2010;32(6):430-433 In humans, omega-6 (n-6) and omega-3 (n-3) series fatty acids are important to maintain cell membranes, brain function and nerve impulse transmission.(1) Linoleic (LA, 18:2 n-6) and alpha-linolenic (LNA, 18:3 n-3) acids are strictly essential fatty acids, which must be obtained through the diet. The other n-6 and n-3 fatty acids can be synthesized from LA and LNA or be obtained through the diet.Of the n-6 and n-3 series fatty acids of nutritional value, arachidonic (AA, 20:4 n-6), eicosapentaenoic (EPA, 20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) acids are the most important.As in the human body, LA, an n-6 fatty acid, must be converted into AA, and LNA, an n-3 fatty acid, into EPA and DHA in order for them to exercise their functions, many kinetic studies are performed to measure these conversions from diets with different n-6/n-3 ratios.( 1) The first step in the process to assess the fatty acid composition of different foods and biological materials is to extract the lipids. Extraction methods are crucial to accurately measure fatty acid concentrations, as methods may degrade some fatty acids, especially polyunsaturated fatty acids and thus overestimate the true values.Accordingly, in this issue of the Journal of Hematology and Hemotherapy, a study by Morais et al. Bligh and Dyer, (4) Rose-Gottlieb, (5) and Gerber (6) and an alternative technique, proposed by the authors, with the objective of comparing the efficiency of lipid extraction and to evaluate the fatty acid composition in total lipids from human plasma.

show abstract

Section: Neonatal Jaundice and Glucose-6-phosphate Dehydrogenasementioning

confidence: 88%

Icterícia neonatal e deficiência de glicose-6-fosfato desidrogenase

Leite¹

2010

Rev. Bras. Hematol. Hemoter.

View full text Add to dashboard Cite

show abstract

“…Nicolielo et al (2006) estudando 2657 amostras de sangue colhidas no laboratório de análises clínicas da Universidade do Sagrado Coração, Bauru/SP de indivíduos do sexo masculino, encontraram uma prevalência de deficiência de G6PD de 3,6%. Discutem que no Brasil, entre homens de ascendência africana, a Discussão prevalência da deficiência de G6PD estaria em torno de 10% enquanto que para homens de ascendência caucasiana entre e 3% 100 .…”

unclassified

Triagem neonatal de deficiência de glicose-6-fosfato desidrogenase e prevalência das mutações G202A (G6PD A-) e C563T (G6PD Mediterrâneo) em Mato Grosso/Brasil

Ferreira¹

View full text Add to dashboard Cite

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Monteiro

Franca

Queiroz

et al. 2014

Malar J

View full text Add to dashboard Cite

BackgroundAlthough G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce understanding of the burden of clinical manifestation underlying G6PDd carriage. The aim of this work was to study the clinical significance of G6PDd in LA and the Caribbean region through a systematic review.MethodsA systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Only original research was included. All study designs were included, as long as any clinical information was present. Studies were eligible for inclusion if they reported clinical information from populations living in LA or Caribbean countries or about migrants from these countries living in countries outside this continent.ResultsThe Medline search generated 487 papers, and the LILACS search identified 140 papers. After applying the inclusion criteria, 100 original papers with any clinical information on G6PDd in LA were retrieved. Additionally, 16 articles were included after reading the references from these papers. These 116 articles reported data from 18 LA and Caribbean countries. The major clinical manifestations reported from LA countries were those related to AHA, namely drug-induced haemolysis. Most of the published works regarding drug-induced haemolysis in LA referred to haemolytic crises in P. vivax malaria patients during the course of the treatment with primaquine (PQ). Favism, infection-induced haemolysis, NNJ and CNSA appear to play only a minor public health role in this continent.ConclusionHaemolysis in patients using PQ seems to be the major clinical manifestation of G6PDd in LA and contributes to the morbidity of P. vivax infection in this continent, although the low number of reported cases, which could be linked to under-reporting of complications. These results support the need for better strategies to diagnose and manage G6PDd in malaria field conditions. Additionally, Malaria Control Programmes in LA should not overlook this condition in their national guidelines.

show abstract

Atividade da 6-fosfogliconato desidrogenase em deficientes de glicose-6-fosfato desidrogenase

Cited by 5 publications

References 7 publications

Icterícia neonatal e deficiência de glicose-6-fosfato desidrogenase

Icterícia neonatal e deficiência de glicose-6-fosfato desidrogenase

Triagem neonatal de deficiência de glicose-6-fosfato desidrogenase e prevalência das mutações G202A (G6PD A-) e C563T (G6PD Mediterrâneo) em Mato Grosso/Brasil

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Contact Info

Product

Resources

About