2014
DOI: 10.1186/1475-2875-13-70
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Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Abstract: BackgroundAlthough G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce understanding of the burden of clinical manifestation underlying G6PDd carriage. The aim of this work was to study the clinical significa… Show more

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Cited by 48 publications
(58 citation statements)
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“…A recent systematic review has shown that among all published cases of haemolysis triggered by various oxidative agents in LA, none have involved Amerindians (Monteiro et al 2014). Reinforcing these results, in Nicaragua, the administration of 10-20 mg of PQ base during 14 days to 321 Miskito Amerindians with chronic malaria did not lead to any report of secondary haemolysis (Thaeler Jr et al.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…A recent systematic review has shown that among all published cases of haemolysis triggered by various oxidative agents in LA, none have involved Amerindians (Monteiro et al 2014). Reinforcing these results, in Nicaragua, the administration of 10-20 mg of PQ base during 14 days to 321 Miskito Amerindians with chronic malaria did not lead to any report of secondary haemolysis (Thaeler Jr et al.…”
Section: Resultsmentioning
confidence: 99%
“…A broad free text search was made using a previously published search strategy (Monteiro et al 2014). Potentially relevant papers in all languages were accessed from MEDLINE and LILACS for a review of the full texts.…”
Section: Methodsmentioning
confidence: 99%
“…A large burden of P. vivax, which is more difficult to eliminate than P. falciparum,poses a significant barrier to malaria elimination [18]. The latent hepatic stages of P. vivax are mainly responsible for subsequent relapses after the first clinical episode [19]. Primaquine is an important medication for case management, whether it is P. vivax or P. falciparum malaria.…”
Section: Introductionmentioning
confidence: 99%
“…[4][5][6] In patients with the X-linked erythrocyte enzyme disorder glucose-6-phosphate dehydrogenase deficiency (G6PDd), primaquine causes dose-dependent acute haemolytic anaemia (AHA) that is greater in the more severe deficient G6PD variants, AHA can be potentially life threatening but primaquine-related deaths are very rare. [7][8][9][10][11][12][13] This toxicity is a significant public health concern because G6PDd affects approximately 400 million people who live mostly in malaria-endemic countries where the median G6PDd allele prevalence is 8%. Testing for G6PDd is not performed in the majority of malariaendemic countries.…”
Section: Introductionmentioning
confidence: 99%