Atherosclerotic disease in octogenarians: A challenge for science and clinical practice

Sarcopenia en pacientes coronarios hospitalizados

“…Therefore, it is difficult to carry out a comparative analysis with previously published data. Atkin et al 8 report that together, sarcopenia and obesity may increase the magnitude of effects on metabolic diseases, cardiovascular diseases and mortality rates as compared with obesity or sarcopenia alone.…”

“…However, studies have shown that small muscle mass is associated with arterial stiffness, which is an independent predictor of cardiovascular disease (CVD). Sarcopenia may also affect the atherogenesis process due to the relative increase in secondary adipose tissue, muscle loss and replacement of myocytes by adipocytes 8,9 . In addition, when sarcopenia and obesity co-occur, there is a synergy which may result in muscle loss and dysfunction related to a pathological accumulation of adipose tissue.…”

SIRT1: Role in cardiovascular biology

“…Telomere depletion leads to senescence of vascular smooth muscle cells and endothelial cells. It has been indicated that the telomere length is a marker for premature aging of blood vessels and increased risk of cardiovascular diseases [117,118], which play an important role in cardiovascular diseases such as atherosclerosis [119,120]. SIRT1 has been proven capable of inhibiting telomere shortening because of its essential role in gene silencing [7,121].…”

Enhanced parathyroid hormone levels are associated with left ventricle hypertrophy in very elderly men and women

“…1 Among these newly appointed mechanisms, calcium metabolism has recently attracted attention due to the consistency in studies that show an association between low bone mass and cardiovascular mortality. 2,3 Particularly, increased serum levels of parathyroid hormone (PTH) have been found to be a predictor of cardiovascular mortality in the frail 4,5 as well as in community-dwelling elderly men.…”