Enhanced parathyroid hormone levels are associated with left ventricle hypertrophy in very elderly men and women

Soares, Ana Flávia; Freitas, Wladimir M.; Japiassú, André V.T.; Quaglia, Luiz A.; Santos, Simone N.; Pereira, Alexandre C.; Nadruz, Wilson; Sposito, Andrei C.

doi:10.1016/j.jash.2015.06.020

Cited by 19 publications

(11 citation statements)

References 34 publications

(39 reference statements)

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“…35 Clinical studies reveal that a high iPTH level promotes aortic valve calcification and causes myocardial injuries, including cardiac hypertrophy, myocardial calcification and myocardial fibrosis. [36][37][38] PTx, through reducing serum Ca and P levels, can dramatically reduce iPTH levels, better controls serum minerals and simultaneously suppress extraosseous calcification stress. 39 These favorable changes in mineral metabolism are the most proximate mechanisms underlying that PTx may improve survival and cardiovascular outcomes.…”

Section: Discussionmentioning

confidence: 99%

Long–term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis

Chen

Wang

et al. 2016

Renal Failure

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Parathyroidectomy (PTx) and medical treatments are both recommended for reducing serum intact parathyroid hormone (iPTH) and curing secondary hyperparathyroidism (sHPT) in patients with chronic kidney disease (CKD), but their therapeutic effects on long-term mortality are not well-known. Thus, we aim to assess such therapeutic effect of PTx. Electronic literatures published on Pubmed, Embase, and Cochrane Central Register of Controlled Trials in any language until 27 November 2015 were systematically searched. All literatures that compared outcomes (survival rate or mortality rate) between PTx-treated and medically-treated CKD patients with sHPT were included. Finally, 13 cohort studies involving 22053 patients were included. Data were extracted from all included literatures in a standard form. The outcomes of all-cause and cardiovascular mortalities were assessed using DerSimonian and Laird's random effects model. We find PTx-treated versus medically-treated patients had a 28% reduction in all-cause mortality and a 37% reduction in cardiovascular mortality. Thus, PTx versus medical treatments might reduce the risks of all-cause and cardiovascular mortalities in CKD patients with sHPT. Further studies with prospective and large-sample clinical trials are needed to find out the real effect of PTx and to assess whether mortality rates differ among patterns of PTx. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Long–term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis

Chen

Wang

et al. 2016

Renal Failure

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“…[ 25 ] In addition, PTH is also linked to arterial hypertension [ 26 , 27 ] and left ventricular hypertrophy. [ 28 ]…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone and risk of heart failure in the general population

Meng

Wang²,

Ma³

et al. 2016

Medicine

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Inconsistent findings have been reported on the association between the parathyroid hormone (PTH) level and risk of heart failure. We aimed to systematically evaluate the association between circulating level of PTH and risk of heart failure in the general population by conducting a meta-analysis. We made a comprehensive literature search in PubMed, Embase, VIP, CNKI, and Wanfang databases published until January 2016. Only prospective observational studies reporting the association between circulating level of PTH and risk of heart failure in the general population were selected. Pooled adjusted hazard ratio (HR) and corresponding 95% confidence intervals (CIs) were calculated for the highest versus lowest PTH category. Six studies with 25,207 participants identified. Higher circulating level of PTH was associated with an increased risk of heart failure (HR: 1.38; 95% CI 1.09–1.74) in a random effect model. Subgroup analyses revealed that the risk of heart failure was more pronounced among men (HR: 1.75; 95% CI 1.38–2.22) than in both genders. However, the risk increment was not statistically significant (HR: 1.12; 95% CI 0.76–1.66) in the middle-aged population. Higher PTH level is independently associated with an exacerbated risk of heart failure in the general population.

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“…PTH'ın aşırı artışının kalp ve arter duvarını etkilediği hem yapısal hem de fonksiyonel bozukluklarla ilişkili olduğu anlaşıldıktan sonra bu konuda yapılan çalışmalar sıklaşmıştır [8,13,14]. Soares ve arkadaşları [15]…”

Section: Paratiroid Hormon Ve Sol Ventrikül Hipertrofisiunclassified

Normokalsemik hiperparatiroidiye farklı bakış: kardiyak sorunların gözden geçirilmesi

Alp¹,

Karahan²,

Durmaz³

2018

TURKISH JOURNAL of CLINICS and LABORATORY

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Hiperparatiroidizmde renal komplikasyonlar ve osteoporoz gibi yan etkiler klinisyenler tarafından çok iyi bilinerek sıkı takip edilmektedir. Bununla birlikte yapılan çeşitli çalışmalarda hiperparatiroidiye bağlı hipertansiyon, diastolik disfonksiyon, endotel disfonksiyonu, kalp kapak kalsifikasyonu, aritmi, kardiyak hipertrofi gibi yan etkiler belirtilmiştir. Bazı çalışmalar hiperparatiroidide kardiak mortalite artışı olduğunu işaret etmektedir. Bu derlemede primer hiperparatiroidide rastlanan kardiyak sorunlara dikkat çekmek amaçlanmıştır.

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Enhanced parathyroid hormone levels are associated with left ventricle hypertrophy in very elderly men and women

Cited by 19 publications

References 34 publications

Long–term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis

Long–term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis

Parathyroid hormone and risk of heart failure in the general population

Normokalsemik hiperparatiroidiye farklı bakış: kardiyak sorunların gözden geçirilmesi

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