Atenolol release from hydrophilic matrix tablets with hydroxypropylmethylcellulose (HPMC) mixtures as gelling agent: effects of the viscosity of the HPMC mixture

Vázquez, M. J.; Casalderrey, Marta; Duro, R.J.; Gómez-Amoza, J.L.; Martínez‐Pacheco, Ramón; Souto, C.; Concheiro, Angel

doi:10.1016/0928-0987(95)00030-5

Cited by 39 publications

(12 citation statements)

References 14 publications

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“…The K and MDT values for attrition and drug at release respectively (Table 2) supports this. This is in line with earlier reports that the release of a water soluble drug from Cp and HPMC matrix systems is basically diffusion controlled (11,15). The kinetics of aminophyline release from the various matrix tablets were similar, and predominantly indicating diffusion (n = 0.45) or a combination of diffusion and dissolution of the matrix system (n > 0.45 < 0.89) in both SGF and SIF.…”

Section: Release Studiessupporting

confidence: 79%

“…Attrition which is as a result of surface stress in the dissolution medium is characterized by the loss of polymer and other insoluble component (11). In vitro and in vivo experiments have shown that the rate of weight loss and drug release from swellable matrix tablets in the human stomach is a primary consequence of both attrition and diffusion.…”

Section: Attrition Profilementioning

confidence: 99%

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Evaluation of the controlled release potential of

Builders¹,

Okeke²,

Egieye³

2008

J. Phyto. Therap.

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The suitability of A. digitata mucilage (ADM) as an excipient in the formulation of matrix tablets, the mechanism and kinetics of drug delivery were studied. Aminophyline was the prototype drug while these properties were compared to those of HPMC and Cp. ADM was used at concentration levels of 10, 15 and 30% of the tablet weight while HPMC and Cp were used at 30% concentration. The tablet friability, attrition and dissolution characteristics were evaluated. All the tablets formulated showed good physical properties. The ADM matrix tablets showed similar drug release and attrition pattern to those of Cp in both SIF and SGF. Generally the drug release retardation efficiency of the ADM tablets at equal polymer concentration was higher than those of Cp but less than that of HPMC in both SGF and SIF. The mechanism of release of aminophyline from ADM as in Cp and HPMC was by diffusion.

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Section: Release Studiessupporting

confidence: 79%

Section: Attrition Profilementioning

confidence: 99%

Evaluation of the controlled release potential of

Builders¹,

Okeke²,

Egieye³

2008

J. Phyto. Therap.

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“…It is a popular carrier material for swellable matrix tablets. 11 The drug release from HPMC-tablets can be modified by changing variables such as the viscosity grade or the particle size of HPMC, 12,13 or the HPMC: filler ratio or HPMC: drug ratio, 14−16 or the solubility of the filler 17 or by the addition of other hydrophilic polymers. 18 Depending on the solubility of the drug, the drug is primarily released either by diffusion through a gelled layer or erosion of this layer.…”

Section: −5mentioning

confidence: 99%

Development of Polymeric Blend Microspheres from Chitosan-Hydroxypropylmethyl Cellulose for Controlled Release of an Anti-Cancer Drug

Reddy¹,

Reddy²,

Rao³

et al. 2013

Journal of the Korean Chemical Society

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ABSTRACT. Chitosan (CS) and hydroxypropylmethyl cellulose (HPMC) blend microspheres were prepared by water-in-oil emulsion technique and were loaded with an anti-cancer drug 5-fluorouracil (5-FU). CS-HPMC microspheres were characterized by Fourier transform infrared spectroscopy to confirm the cross-linking reaction. Scanning electron microscopy (SEM) was also used to assess the surface morphology of particles prepared. The quantity of release of 5-FU from the microspheres have been studied in terms of blend composition and amount of cross-linking agent. Differential scanning calorimetry and X-ray diffraction techniques indicated a uniform distribution of 5-FU particles in microspheres, whereas SEM suggested the spherical structure of the microspheres with slight rough surface. The in vitro drug release indicated that the particle size and release kinetics depend upon blend composition, amount of cross-linking agent used and amount of 5-FU present in the microspheres.

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“…However, little work has been done to study the influence of lot-to-lot apparent viscosity difference on in vitro dissolution. Also, not much has been done to compare the effect of using a single grade of HPMC versus a mixture of two different grades of HPMC on drug release [148]. The current apparent viscosity range specification for HPMC given by the manufacturer is 11,250-21,000 cps [149] and two lots of this polymer may differ widely from each other in terms of apparent viscosity.…”

Section: Hydroxypropyl Methyl Cellulosementioning

confidence: 99%

Pharmaceutical significance of cellulose: A review

Kamel¹,

Ali²,

Jahangir³

et al. 2008

Express Polym. Lett.

374

191

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Abstract. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. Polymeric delivery systems are mainly intended to achieve controlled or sustained drug delivery. Polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled-release dosage forms and the most abundant naturally occurring biopolymer is cellulose; so hdroxypropylmethyl cellulose, hydroxypropyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose can be used for production of time controlled delivery systems. Additionally microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose as well as hydroxypropyl cellulose are used to coat tablets. Cellulose acetate phthalate and hydroxymethyl cellulose phthalate are also used for enteric coating of tablets. Targeting of drugs to the colon following oral administration has also been accomplished by using polysaccharides such as hdroxypropylmethyl cellulose and hydroxypropyl cellulose in hydrated form; also they act as binders that swell when hydrated by gastric media and delay absorption. This paper assembles the current knowledge on the structure and chemistry of cellulose, and in the development of innovative cellulose esters and ethers for pharmaceuticals.

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Atenolol release from hydrophilic matrix tablets with hydroxypropylmethylcellulose (HPMC) mixtures as gelling agent: effects of the viscosity of the HPMC mixture

Cited by 39 publications

References 14 publications

Evaluation of the controlled release potential of

Evaluation of the controlled release potential of

Development of Polymeric Blend Microspheres from Chitosan-Hydroxypropylmethyl Cellulose for Controlled Release of an Anti-Cancer Drug

Pharmaceutical significance of cellulose: A review

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