Asymptomatic Mild Intermittent Proteinuria

Muth, Robert G.

doi:10.1001/archinte.1960.03860170051012

Cited by 28 publications

(4 citation statements)

References 12 publications

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“…37,38 Orthostatic (postural) proteinuria occurs only in the upright position. [39][40][41][42] It is persistent but benign, and it completely normalizes in the recumbent position. It is seen primarily in young adults, usually is less than 1 g/24 hours, and is thought to be due to an alteration in glomerular hemodynamics.…”

Section: S Consider Factors That Affect Protein Excretionmentioning

confidence: 99%

Proteinuria: how to evaluate an important finding.

Kashif¹,

Siddiqi²,

Dincer³

et al. 2003

Cleveland Clinic Journal of Medicine

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Section: S Consider Factors That Affect Protein Excretionmentioning

confidence: 99%

Proteinuria: how to evaluate an important finding.

Kashif¹,

Siddiqi²,

Dincer³

et al. 2003

Cleveland Clinic Journal of Medicine

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“…reported that proteinuria, even intermittent proteinuria, might not be a benign condition. They biopsied 51 young asymptomatic patients with intermittent proteinuria and normal renal function (age, 16–34 years) and found that approximately two-thirds of patients had pathologic evidence of renal disease [12]. As these data show, proteinuria in young adults may not be as benign as previously thought.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, previous investigators found that even mild intermittent proteinuria in asymptomatic young individuals is frequently associated with significant underlying renal pathology, emphasizing that it may not be a benign condition [12]. …”

Section: Introductionmentioning

confidence: 99%

High pulse pressure and metabolic syndrome are associated with proteinuria in young adult women

Kim

Moon

et al. 2013

BMC Nephrol

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BackgroundObesity and metabolic syndrome play causative roles in the increasing prevalence of proteinuria in the general population. However, in young adult women the clinical significance of incidentally discovered proteinuria and its association with metabolic syndrome are unclear. We investigated the prevalence and risk factors for proteinuria in this population.MethodsA total of 10,385 women aged 20 to 39 years who underwent health screenings were surveyed. Each patient was tested for proteinuria with a dipstick (−, ±, 1+, 2+, or 3+), and proteinuria was defined as 1+ or greater. Persistent proteinuria was established by confirming proteinuria in a subsequent test. Metabolic syndrome was defined in accordance with the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asia.ResultsThe mean age was 28.9 ± 5.5 years, and the prevalence of persistent proteinuria was 1.0%. Among these subjects with persistent proteinuria, obesity and metabolic syndrome were found in 10.4% and 5.2%, respectively. Metabolic syndrome, as well as its components of hypertension, hyperglycemia, central obesity, low high-density lipoprotein levels, and high triglyceride levels, was closely related to the presence of proteinuria. In addition, a wide pulse pressure of ≥40 mmHg was another independent risk factor for proteinuria [odds ratio (OR) 3.29, 95% confidence interval (CI) 1.03–11.91)]. This had an additive effect on metabolic syndrome in terms of predicting proteinuria. Even in subjects without metabolic syndrome, the influence of an increased pulse pressure was consistent (OR 2.75, 95% CI 1.03–8.61).ConclusionsSpecific attention to proteinuria may be necessary in asymptomatic young women aged 20 to 39 years if they have metabolic syndrome or a wide pulse pressure.

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“…Los pacientes con este tipo de proteinuria benigna presentan proteinuria independiente de la posición corporal en al menos un 50% de las muestras de orina recogidas al azar, pero no en todas. [35][36][37] La mayoría de los pacientes son jóvenes, menores de 30 años, presentan exámenes de función renal normal y mantienen presiones arteriales normales. En biopsias renales, se ha mostrado que hasta el 60% de los pacientes pueden presentan lesiones glomerulares leves que incluyen esclerosis e hipercelularidad.…”

Section: Proteinuria Intermitente Idiopáticaunclassified

Proteinuria, fisiología y fisiopatología aplicada

Gómez

Sánchez

Montero

2009

AMC

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La proteinuria está definida por la presencia de proteínas en la orina. En los adultos se refiere a una excreción urinaria de estas superior a 150 mg en 24 horas. Se ha utilizado como un marcador de lesión renal, constituyéndose en uno de los datos más importantes para el nefrólogo. Sin embargo, patologías tan comunes como la hipertensión arterial y la Diabetes Mellitus frecuentemente manifiestan sus afecciones renales con la presencia de proteinuria, convirtiéndose ahora en un marcador de enfermedades sistémicas y no solo renales. Normalmente, un individuo filtra 5000 mg de proteínas cada día, de los cuales 4950 mg son reabsorbidos en el túbulo proximal del riñón, de manera que la cantidad excretada es poca. En el presente artículo se exponen los diferentes tipos de proteinuria con base en conceptos fisiopatológicos. Hay varios métodos de laboratorio que permiten la cuantificación de la proteinuria, siendo la relación proteinuria creatinuria y la orina de 24 horas las más utilizadas. La relevancia de esta revisión se muestra al tomar en cuenta que la proteinuria es el factor aislado más importante para determinar el avance y progresión de la enfermedad renal. También se ha mostrado que el riesgo añadido por la presencia de proteinuria fue superior al causado por el tabaco, la diabetes o la hipertrofia ventricular izquierda para la presencia de eventos isquémicos cardiovasculares. La proteinuria es más que solo proteínas en la orina, es una señal de alerta.

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Asymptomatic Mild Intermittent Proteinuria

Cited by 28 publications

References 12 publications

Proteinuria: how to evaluate an important finding.

Proteinuria: how to evaluate an important finding.

High pulse pressure and metabolic syndrome are associated with proteinuria in young adult women

Proteinuria, fisiología y fisiopatología aplicada

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