High pulse pressure and metabolic syndrome are associated with proteinuria in young adult women

Abstract

BackgroundObesity and metabolic syndrome play causative roles in the increasing prevalence of proteinuria in the general population. However, in young adult women the clinical significance of incidentally discovered proteinuria and its association with metabolic syndrome are unclear. We investigated the prevalence and risk factors for proteinuria in this population.MethodsA total of 10,385 women aged 20 to 39 years who underwent health screenings were surveyed. Each patient was tested for proteinuria with a dipstick (−, ±, 1+, 2+, or 3+), and proteinuria was defined as 1+ or greater. Persistent proteinuria was established by confirming proteinuria in a subsequent test. Metabolic syndrome was defined in accordance with the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asia.ResultsThe mean age was 28.9 ± 5.5 years, and the prevalence of persistent proteinuria was 1.0%. Among these subjects with persistent proteinuria, obesity and metabolic syndrome were found in 10.4% and 5.2%, respectively. Metabolic syndrome, as well as its components of hypertension, hyperglycemia, central obesity, low high-density lipoprotein levels, and high triglyceride levels, was closely related to the presence of proteinuria. In addition, a wide pulse pressure of ≥40 mmHg was another independent risk factor for proteinuria [odds ratio (OR) 3.29, 95% confidence interval (CI) 1.03–11.91)]. This had an additive effect on metabolic syndrome in terms of predicting proteinuria. Even in subjects without metabolic syndrome, the influence of an increased pulse pressure was consistent (OR 2.75, 95% CI 1.03–8.61).ConclusionsSpecific attention to proteinuria may be necessary in asymptomatic young women aged 20 to 39 years if they have metabolic syndrome or a wide pulse pressure.

Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction

“…Furthermore, in another clinical study, authors examined the role of insulin resistance versus hyperglycemia in the risk for coronary heart disease and explore the interaction of insulin resistance with hyperglycemia. Interestingly, their data show that insulin resistance to be a greater risk for D r a f t 4 coronary heart disease than diabetes, indicating how non-diabetics can have a higher risk for coronary heart disease than diabetics when insulin resistance is elevated (Kim et al 2013).…”

“…Insulin resistance is one of the important risk factors for several pathological conditions including hypertension (Guo et al 2005;Xi et al 2004), and type-2 diabetes (Fontes-Carvalho et al 2015;Lee and McDonald 2015;Lopez-Jaramillo et al 2014;Streja 2004) while it even predicts coronary heart disease in either adult or elderly non-diabetic subjects (Kim et al 2013; Lempiainen et al 1999). Furthermore, it has been demonstrated that high dietary sucrose triggers hyperinsulinemia, increases myocardial β-oxidation, reduces glycolytic flux and delays post-ischemic contractile recovery.…”

Función glomerular y síndrome metabólico en adultos venezolanos con factores de riesgo cardiometabólico atendidos en un centro de atención primaria

“…Con cada componente adicional del SM presente, el riesgo de disminución de la TFGe y de proteinuria se incrementó entre 1,5 y 1,7, respectivamente. En conjunto estos resultados concuerdan con investigaciones realizadas en adultos chinos 8 , japoneses 10 y coreanos 23,24 . Asimismo, refuerzan la importancia en atención primaria de la detección e instauración de medidas tendientes a la prevención y erradicación del SM, como un medio para reducir el riesgo de disminución leve de la función glomerular, considerando que dicha reducción se ha identificado como predictor de la progresión hacia ECR 12 .…”

Hubungan Kadar HBA1C dengan Albuminuria pada Pasien DM Tipe II di RS Atma Jaya

“…21 Penelitian Kim J-K. menyatakan bahwa lama dari menderita DMT2 berpengaruh pada perkembangan proteinuria. 22 Penelitian di Surabaya menyatakan bahwa usia sejalan dengan meningkatnya insiden DMT2 akibat produksi dari sel â yang berkurang. Risiko terkena komplikasi kronis lebih tinggi karena toleransi glukosa yang semakin buruk.…”