Asymptomatic dogs are highly competent to transmit Leishmania (Leishmania) infantum chagasi to the natural vector

Laurenti, Márcia Dalastra; Rossi, Cláudio Nazaretian; Matta, Vânia Lúcia Ribeiro da; Tomokane, Thaíse Yumie; Corbett, Carlos Eduardo Pereira; Secundino, Nágila Francinete Costa; Pimenta, P. F. P.; Marcondes, Mary

doi:10.1016/j.vetpar.2013.03.017

Cited by 155 publications

(139 citation statements)

References 20 publications

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“…The role of canines as disease reservoirs has been well established 35,36 . In our study, the observed canine infection positivity rate of approximately 24% was high compared to other endemic cities and did not correlate with the number of human cases or the abundance of Lu.…”

mentioning

confidence: 99%

Spatial and seasonal distribution of Lutzomyia longipalpis in Dracena, a city in the western region of the State of São Paulo, Brazil, that is endemic with visceral leishmaniasis

Holcman

Sampaio

Rangel

et al. 2013

Rev. Soc. Bras. Med. Trop.

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mentioning

confidence: 99%

Spatial and seasonal distribution of Lutzomyia longipalpis in Dracena, a city in the western region of the State of São Paulo, Brazil, that is endemic with visceral leishmaniasis

Holcman

Sampaio

Rangel

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…From experimental studies, it has been known that these wild animals do not often reveal symptoms and experience frequent re-infections [1,16,17]. Such evidence helps us to assume that all individuals never die of the infection and acquire immunity, and thus, to adopt an susceptible-infectious-susceptible (SIS) model [18][19][20][21][22][23][24].…”

Section: Methodsmentioning

confidence: 99%

Examining the reservoir potential of animal species for $$\varvec{\textit{Leishmania infantum}}$$ Leishmania infantum infection

Fukami

Nishiura

2015

Japan J. Indust. Appl. Math.

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Leishamaniasis is a parasitic disease transmitted by sandfly Phlebotomus spp. and is seen in tropical and subtropical countries in which an estimated 12 million persons are infected. Among various types of leishmaniasis, zoonotic visceral leishmaniasis (ZVL) caused by Leishmania infantum is an important amphixenosis shared by human and other animals. Although identifying the natural reservoir host would help better understand the transmission dynamics of Leishmania spp., little effort has been made to quantitatively clarify the dynamics involving the reservoir host of ZVL. The present study investigated the reservoir potential of four wild animals in maintaining ZVL, using prevalence data from Latin American countries in Amazons and examining the role of crab-eating fox, spiny rat, common opossum and black rat in maintaining the transmission. Reflecting frequent reinfections, a susceptible-infectedsusceptible model was employed, enabling us to estimate model parameters from endemic prevalence data. The next generation matrix of the multi-host system was computed, permitting us to theoretically examine the reservoir potential of each animal species. Our estimates indicated that there is no unique reservoir host consisting of single animal species. Crab eating fox was considered to play an important role in maintaining L. infantum transmission, but this was the case only in combination with other hosts. The present study indicates that animal species other than canine play important roles in maintaining transmission of Leishmania infantum, which is different from conventional wisdom that centered on the importance of canine only. Greater sample size with additional entomological and genetic insights into inter-specific contact would be required to implement more explicit assessments.

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“…Le chien est une espèce majeure sensible à L. infantum : fré-quemment infecté en zone d'endémie, il peut rester en état asymptomatique et infectant pour les phlébotomes ou exprimer la maladie (Laurenti et al 2013). La quantité de leishmanies dans le derme croît avec l'ancienneté et la sévérité de la maladie, et constitue un marqueur fiable du pouvoir infectant du chien pour le vecteur (Courtenay et al 2014).…”

Section: Espèces Affectéesunclassified

La leishmaniose canine à Leishmania Infantum : actualités épidémiologiques – applications

Bourdoiseau¹

2015

bavf

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La leishmaniose canine est une maladie vectorielle due à Leishmania infantum principalement transmis par la piqûre de phlébotomes. Le rôle épidémiologique du chien qu'il soit sain, malade, infecté asymptomatique ou vacciné est très important puiqu'il représente la source principale de parasites pour le vecteur. Mais le rôle épidémiologique d'espèces animales sauvages (lapin, lièvre,…) nécessite des investigations complémentaires pour une meilleure efficacité contre cette maladie. Le déplacement ou l'importation de chiens infectés associé aux modifications climatiques contribue à une incidence significative des cas cliniques humains et canins. La vaccination associée à l'utilisation de topiques insecticides doit être recommandée pour tout chien vivant ou se déplaçant en zones d'endémie. Mots

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Asymptomatic dogs are highly competent to transmit Leishmania (Leishmania) infantum chagasi to the natural vector

Cited by 155 publications

References 20 publications

Spatial and seasonal distribution of Lutzomyia longipalpis in Dracena, a city in the western region of the State of São Paulo, Brazil, that is endemic with visceral leishmaniasis

Spatial and seasonal distribution of Lutzomyia longipalpis in Dracena, a city in the western region of the State of São Paulo, Brazil, that is endemic with visceral leishmaniasis

Examining the reservoir potential of animal species for $$\varvec{\textit{Leishmania infantum}}$$ Leishmania infantum infection

La leishmaniose canine à Leishmania Infantum : actualités épidémiologiques – applications

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