Asymptomatic Bacteriuria in Antenatal Patients in Ilorin, Nigeria

Ajayi, A B; Nwabuisi, C; Aboyeji, Abiodun P.; Ajayi, Nanji S; Fowotade, Adeola; Fakeye, O

doi:10.5001/omj.2012.06

Cited by 40 publications

(41 citation statements)

References 17 publications

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“…8 Various studies in India have reported the prevalence ranging from 6% to 22%.2,9,10 Reports from across the world has documented a prevalence of as high as 40-45%. 11,12 As per the present study higher incidence of ASB was seen in the second trimester of pregnancy 8 (57.1%) which was similar to Nath et al and Roy et al 7,13 Yasodhara et al has reported higher incidence of ASB in the first trimester of pregnancy in contrast to our study. 14 Higher incidence in the second trimester of pregnancy could be due the anatomical changes occurring in the uterus, structural and functional changes in the urinary tract like dilatation of ureters favoring stasis of urine leading on to infection.…”

Section: Discussioncontrasting

confidence: 57%

Asymptomatic bacteriuria among antenatal women attending a tertiary care hospital in Kanchipuram: evaluation of screening tests and antibiotic susceptibility pattern

et al. 2016

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INTRODUCTIONUrinary tract infections are a common health problem and are more common in women compared to men. 1 The altered physiological, anatomical and hormonal changes during Pregnancy makes the antenatal mother more prone for Urinary tract infection. Such infections can be either symptomatic or asymptomatic. The term asymptomatic bacteriuria (ASB) is used when a bacterial count of the same species over 10⁵/ ml in midstream clean catch specimen of urine is obtained on two occasions without symptoms of urinary tract infection.2 This is very ABSTRACTBackground: Asymptomatic bacteriuria (ASB) occurring in pregnant women can lead onto complications like acute pyelonephritis, hypertensive disease of pregnancy, premature delivery and intrauterine growth retardation if untreated. Methods:The present study aims to estimate the occurrence of asymptomatic bacteriuria in antenatal women and to study the antibiotic susceptibility pattern of the isolates. The Gram staining, pus cell count and culture was performed for 120 urine samples. Antibiotic susceptibility testing was done by Kirby Baeur disk diffusion method. MRSA (Methicillin resistant Staphylococcus aureus) and ESBL (Extended spectrum Beta Lactamases) producers were identified by Standard guidelines. The sensitivity, specificity, negative predictive values and positive predictive values of Gram staining and pus cell count was calculated. Results: Out of the 120 samples 14 (11.66%) were positive for asymptomatic bacteriuria. The Gram staining showed specificity and negative predictive value of 95.2% and 98.1% respectively. Pus cell count showed a specificity and negative predictive value of 96.29% and 98.11% respectively. Escherichia coli were the predominant species isolated 5 (35.7%). Among the gram negative bacteria, amikacin and nitrofurantoin showed a susceptibility of 90% and 80% each. All the staphylococcus aureus isolates showed 100% sensitivity for nitrofurantoin. Two Klebsiella spp and one Escherichia coli isolate were identified as ESBL producers. Among the S. aureus isolates 3 were identified as Methicillin resistant (MRSA). Conclusions: Urine culture should be performed for all pregnant women irrespective of the symptoms and should be treated promptly to prevent the complications arising out of ASB.

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Section: Discussioncontrasting

confidence: 57%

Asymptomatic bacteriuria among antenatal women attending a tertiary care hospital in Kanchipuram: evaluation of screening tests and antibiotic susceptibility pattern

et al. 2016

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“…Even though all pregnant women with ASB received antimicrobial treatment, an increased incidence of preterm labour (RR 3.27, 95% CI 1.38-7.72) and neonatal weight below the 10th percentile (RR 3.79, 95% CI 1.80-7.97) was found in women with ASB in the third trimester compared with women without ASB. Unfortunately, the authors do not provide a definition of 'significant' growth or 'positive culture' in the methods [15]. Another study performed in Nigeria showed a 40% prevalence of ASB (50 of 124 women) in pregnant women between 9 and 24 weeks' gestation.…”

Section: Epidemiologymentioning

confidence: 99%

Asymptomatic bacteriuria and urinary tract infections in special patient groups

Schneeberger

Kazemier

Geerlings

2014

Current Opinion in Infectious Diseases

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SGLT2 inhibitors were associated with a small increased risk for UTI, UTI in diabetic women may lead to bladder and kidney dysfunction, and antibiotic treatment of ASB and UTI during pregnancy was associated with long-term effects on the neonate. Up-to-date research on the effectiveness and long-term effects of ASB screening and treatment policies, including group B Streptococcus bacteriuria in pregnancy, is warranted to inform clinical practice.

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“…A count of less than 10 4 /mL of urine was considered to be not significant. Each significant isolate was identified by colony morphology, gram staining and biochemical reaction according to standard procedures [12,13].…”

Section: Methodsmentioning

confidence: 99%

The Prevalence of Positive Serum Anticardiolipin Antibodies and Asymptomatic Bacteriuria in Women with Recurrent Abortions

Al-khayat

Waheda

Shaker³

2013

EAJM

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Objective: The asymptomatic colonization of the urinary tract in pregnant women may result in severe medical and obstetric complications. The aim of this study was to study the prevalence of asymptomatic bacteriuria in cases of elevated levels of the anticardiolipin antibody in women who experience spontaneous abortions. Materials and Methods:A total of 12 women were enrolled in this case control study, including 60 patients with a history of three or more abortions and 60 healthy pregnant women. All participants were screened for ACL (IgG) and with a urine culture. Results:Overall, 19 (31.7%) patients and seven (11.7%) healthy pregnant women were positive for ACL. The mean concentrations were 67.1±27.2 IU/mL in the patients and 17.41±6.12 IU/mL in the healthy controls (p≤0.05). In the 60 patients, only 17 (28.3%) had significant bacteriuria, whereas 5 (8.3%) women in the control group had significant bacteriuria. The statistical analysis revealed a highly significant difference. Of the 19 patients with a positive elevation of ACL, 11 (57.9%) had significant bacteriuria, and eight (42.1%) had non-significant bacteriuria. Six patients had ACL-negative results associated with significant bacteriuria. The statistical analysis revealed a highly significant difference. Conclusion:A high serum anticardiolipin level was prevalent in women who experienced recurrent abortions associated with asymptomatic bacteriuria.Key Words: Abortion, Anticardiolipin, Asymptomatic bacteriuria Özet Amaç: Gebe kadınlarda idrar yolu asemptomatik kolonizasyonu ciddi tıbbi ve obstetrik komplikasyonlara neden olabilir. Bu çalışmanın amacı kendiliğinden düşük yapan kadınlarda antikardiyolipin antikor düzeylerinin artması durumunda asemptomatik bakteriüri prevalansını araştırmaktır. Gereç ve Yöntem:Bu vaka kontrollü çalışmaya 12 kadın dahil edildi. Geçmiş düşükleri üç ve daha fazla olan 60 ve sağlıklı 60 gebe çalış-maya dahil edildi. Tüm ACL (IgG) ve idrar kültürü açısından tarandı. Bulgular:Tüm hastaların 19'unda (%31.7) ve yedi (%11.7) sağlıklı gebede ACL pozitifti. Ortalama konsantrasyonlar hastalarda 67.1±27.2 IU/mL, sağlıklı kontrollerde 17.41±6.12 IU/mL olarak tespit edildi. 60 hastadan sadece 17 hastada (%28.3) anlamlı bakteriüri varken sağlıklı kontrollerde 5 kişi (%8.3) anlamlı bakteriüri bulunmaktaydı. İstatistik-sel analiz ile oldukça anlamlı fark olduğunu saptanmıştır. 19 hastanın 11'inde (%57.9) ACL'nin pozitif bir elevasyonu varken sekiz hastada (%42.1) anlamlı olmayan bakteriüri olduğu tespit edildi. Altı hastada ACL negatif sonuç ile ilişkili anlamlı bakteriüri mevcuttu.Sonuç: Asemptomatik bakteriüri ile ilişkili tekrarlayan düşüklü kadın-larda yüksek serum antikardiyolipin düzeyi yaygın idi.

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Asymptomatic Bacteriuria in Antenatal Patients in Ilorin, Nigeria

Abstract: The prevalence of asymptomatic bacteriuria in Ilorin is high and routine urine culture is advocated for all pregnant women at booking.

Cited by 40 publications

References 17 publications

Asymptomatic bacteriuria among antenatal women attending a tertiary care hospital in Kanchipuram: evaluation of screening tests and antibiotic susceptibility pattern

Asymptomatic bacteriuria among antenatal women attending a tertiary care hospital in Kanchipuram: evaluation of screening tests and antibiotic susceptibility pattern

Asymptomatic bacteriuria and urinary tract infections in special patient groups

The Prevalence of Positive Serum Anticardiolipin Antibodies and Asymptomatic Bacteriuria in Women with Recurrent Abortions

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