Diabetes mellitus (DM) has been characterized by a metabolic disorder of multipule etiology including hyperglycemia and hyslipidemia along with disturbance in carbohydrate, fat and protein metabolism. 1-3 DM and its associated complications are one of the most prevalent diseases worldwide. Development of multidrug resistant uropathogenic strains in associated with DM is being escalated that helps to determine the prevalence of urinary tract infections (UTIs) among diabetic patients and sensitivity of bacterial isolates against various types of antimicrobial agents. UTIs is one of the most common diseases that encounters in clinical practice today. 4 It is particularly common infection in diabetic patients that occurs in the all ages of both males and females 5 and if it is left untreated, causes considerable morbidity. 6,7UTIs are mainly originated by the bacterial species. Escherichia coli belongs to the specific serogroups of uropathogenic and is considered as frequently identified organism. Serogroups have many virulence factors that are specific for invasion of urinary epithelium. 8 E. coli is the most common cause of the uncomplicated UTI and account for about 95% of all infections. 9 E. coli is the main causative factor for the induction of UTIs in women and also increases the likelihood of persistent UTIs.DM has a number of effects on genitourinary system and has long been considered to be a predisposing factor for UTIs. A characteristic feature observed in UTIs in diabetic patients in the presence of asymptomatic bacteriuria, is more in female than in male patients. The exact reason is not clear, but may be attributed to a number of factors. These include impairment of granulocyte function, increased adherence of uropathogens to uroepithelial cells, dysfunctional bladder and increased in sugar content of urine. 10 Meiland et al. found that longer duration of DM was associated with the risk of asymptomatic bacteriuria. 11 The prevalence of asymptomatic bacteriuria is 15 to 30% higher in diabetic than in non-diabetic women.To the best of our knowledge, limited data regarding the correlation of UTIs and their susceptibility to antibacterial agents in diabetic and non-diabetic patients is available online. The aim of present study was the assessment of UTIs and their susceptibility to various antibacterial agents among diabetic and nondiabetic agents in one of the most populated cities i.e. Lahore of Punjab province, in Pakistan.
Materials and Methods
Study designA cross-sectional study was carried out at one of the largest government hospital located in | Original | Article |
AbstractThe study was undertaken to determine the influence of diabetes mellitus on the uropathogens and antibiotic sensitivity pattern among patients with urinary tract infections (UTIs). A crosssectional study was conducted on 150 diabetic and 250 non-diabetic patients. Out of 160 uropathogenic isolates, Escherichia coli was found as a leading pathogen i.e. 46.2% followed by Candida spp. 30.6%, Streptococcus faecalis 15.6%, Pseudomon...