Associations of the lower urinary tract symptoms with the lifestyle, prostate volume, and metabolic syndrome in the elderly males

Yeh, Hsin Chih; Liu, Chia-Chu; Lee, Yung Chin; Wu, Wen‐Jeng; Li, Wei Ming; Li, Ching Chia; Hour, Tzyh Chyuan; Huang, Ching‐Wen; Chang, Chu Fen; Huang, Shu Pin

doi:10.3109/13685538.2012.669437

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…Conversely, in our study, although prostate volume was significantly greater in BPH patients with MetS than in those without, MetS was only related to a longer duration of LUTS, but not associated with maximum urinary flow rate (one of the factors used to estimate the urethral obstruction grade and detrusor contractility grade in men with LUTS) or IPSS value. Several studies [32,33] investigating the male population in China reported that the presence of any components of MetS was not related to LUTS as assessed by the IPSS, which was similar to our result. LUTS, in addition to causing physical obstruction from prostatic hyperplasia, can be influenced by multiple factors, such as vascular, neurological, muscular abnormalities of the bladder, altered bladder neck compliance and tone, prostate and pelvic floor, aging and lifestyle factors, in a complex interplay [34,35].…”

Section: Discussionsupporting

confidence: 82%

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

et al. 2014

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Objective: The aim of the present study was to evaluate the impact of metabolic syndrome (MetS) on benign prostatic hyperplasia (BPH) in elderly Chinese men. Methods: A total of 401 elderly BPH patients were divided into the without or with MetS group to assess the associations of MetS and components of MetS with BPH. Urologic evaluation included prostate volume, International Prostate Symptom Score, serum prostate-specific antigen, duration of concomitant lower urinary tract symptoms (LUTS) and maximum flow rate. Results: Body mass index (BMI), waist circumference, fasting glucose, glycosylated hemoglobin, triglyceride, fasting insulin (FINS), insulin resistance assessed by homeostasis model assessment (HOMA-IR) were greater and high-density lipoprotein cholesterol (HDL-C) was lower in BPH patients with MetS than in those without MetS. The patients with MetS showed a significantly larger prostate volume (p = 0.000) and longer duration of LUTS (p = 0.006) than those without MetS. Prostate volume was positively correlated with BMI (p = 0.000), FINS (p = 0.001), HOMA-IR (p = 0.003) and inversely correlated with HDL-C (p = 0.000). Multiple linear regression analysis showed that prostate volume was significantly correlated with HOMA-IR (p = 0.015). Conclusions: Our results suggest that MetS, BMI, low HDL-C level, increased serum insulin and especially insulin resistance are considered risk factors for prostate enlargement in elderly Chinese men.

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Section: Discussionsupporting

confidence: 82%

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

et al. 2014

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“…Although a pathophysiological link between components of Met S and LUTS has been proposed [162163], our understanding of the complex interaction between these elements is limited. While a host of studies point to a link between Met S and LUTS (Table 2), other studies have suggested that no relationship exists between Met S and LUTS [164165166]. Thus, large, prospective studies are needed to ascertain such relationship.…”

Section: Discussionmentioning

confidence: 99%

Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

Traish

Johansen

2018

World J Mens Health

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Lower urinary tract function is modulated by neural, vascular and urethral and bladder structural elements. The pathophysiological mechanisms of lower urinary tract symptoms (LUTS) encompass prostate enlargement, alterations in urethra histological structure bladder fibrosis and alterations in pelvic neuronal and vascular networks, The complex pathophysiological relationship between testosterone (T) deficiency (TD) and the constellations LUTS, and metabolic dysfunction manifested in the metabolic syndrome (Met S) remains poorly understood. TD has emerged as one the potential targets by which Met S may contribute to the onset and development as well as worsening of LUTS. Because it has been recognized that treatment of men with Met S with T therapy ameliorates Met S components, it is postulated that T therapy may represent a therapeutic target in improving LUTS. Furthermore, the effect of TD on the prostate remains unclear, and often debatable. It is believed that T exclusively promotes prostate growth, however recent evidence has strongly contradicted this belief. The true relationship between benign prostatic hyperplasia, TD, and LUTS remains elusive and further research will be required to clarify the role of T in both benign prostatic hypertrophy (BPH) and LUTS as a whole. Although there is conflicting evidence about the benefits of T therapy in men with BPH and LUTS, the current body of literature supports the safety of using this therapy in men with enlarged prostate. As the population afflicted with obesity epidemic continues to age, the number of men suffering from Met S and LUTS together is expected to increase.

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“…Increasing evidence has found a relationship between LUTS/BPH and MetS [9,10,11]. However, the severity of LUTS is only one aspect of the clinical progression of BPH.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome: A Prospective Study

Zhou

Yang

et al. 2016

Urol Int

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Objective: To investigate whether metabolic syndrome (MetS) may be associated with the clinical progression of benign prostatic hyperplasia (BPH). Methods: A total of 525 community-dwelling men (aged 45-78) with lower urinary tract symptoms (LUTS) who had complete data at 3-year follow-up were included in this prospective study. International Prostate Symptom Score (IPSS) questionnaire, prostate ultrasonography for prostate volume (PV), maximum urine flow rate (Q_max) and biological parameters were recorded. Participants were divided into a BPH with the MetS group and a BPH without the MetS group, and all received a 3-year follow-up to monitor possible correlations between LUTS/BPH clinical progression and MetS. Results: The results showed that MetS was associated with IPSS, Q_max and PV (p < 0.05) after 3-year follow-up. The mean change of IPSS, PV and Q_max were positively and negatively correlated with time in the BPH with MetS group during the 3-year follow-up. In addition, the BPH clinical progression rate was significantly higher in the BPH with MetS group, compared with the BPH without MetS group (p < 0.05). Diabetes mellitus (DM) and hypertension were related to increased risk of BPH clinical progression. Conclusions: The present results suggest that MetS, in particular, DM and hypertension, may accelerate the clinical progression of BPH in community-dwelling middle-aged and older men.

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Associations of the lower urinary tract symptoms with the lifestyle, prostate volume, and metabolic syndrome in the elderly males

Cited by 19 publications

References 31 publications

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

The Relationship between the Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome: A Prospective Study

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