Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality

Daoud, Eid M.; Ramadan, Mahmoud M.; El-Shahhat, Nader; Elsamad, Ayman A. Abd; El-Malkey, Nader; Sakr, Sherif A.; Bassam, Insaf; Hakeem, Hazem; Eneen, Asmaa; El‐Badrawy, Adel

doi:10.1016/j.ehj.2011.08.022

Cited by 4 publications

(9 citation statements)

References 20 publications

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“…Searches of electronic databases identified 2911 articles of which 43 22–64 were eligible for this review (Figure 1). These described 43 prospective cohort studies enrolling 94,254 individuals.…”

Section: Resultsmentioning

confidence: 99%

“…These described 43 prospective cohort studies enrolling 94,254 individuals. Thirteen studies 25,33,34,37,38,40,43,44,46,49,51,56,59 enrolled participants from general populations, six studies 26–28,35,54,60 enrolled participants with suspected PAD, 14 studies 24,30,31,39,41,42,45,48,52,53,61–64 enrolled participants with cardiovascular or cerebrovascular co-morbidity, five studies 22,29,36,47,57 enrolled participants with diabetes mellitus, two studies 23,55 enrolled dialysis patients, one study 58 enrolled patients with chronic kidney disease, one study 50 enrolled elderly participants with isolated systolic hypertension, and one study 32 enrolled participants with metabolic syndrome. All studies included participants without previous diagnosis of PAD.…”

Section: Resultsmentioning

confidence: 99%

“…All-cause mortality was reported in 35 studies, 22–27,29–34,36,38–43,47,49–58,60–64 enrolling a total of 63,017 individuals (Figure 3). The risk of all-cause mortality was significantly higher in patients with low ABPI than patients with normal ABPI (RR: 2.52, (95% CI 2.26–2.82), P < 0.00001).…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies 22,25,29,33,34,38–42,45,47,48,51,52,57,62 enrolled 29,827 asymptomatic individuals. The results of RR analyses showed that the risk of all-cause mortality; cardiovascular mortality; cerebrovascular event; MI; fatal stroke; fatal MI; and the composite of MI, stroke, and death was significantly higher in asymptomatic individuals with a low ABPI (Supplementary Figure 3).…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies 24,30,31,39,41,42,45,48,52,53,61–64 enrolled 15,756 individuals with cardiovascular or cerebrovascular co-morbidity. The results of RR analyses showed that the risk of all-cause mortality; cardiovascular mortality; cerebrovascular event; MI; and the composite of MI, stroke, and death was significantly higher in individuals with a low ABPI than those with a normal ABPI (Supplementary Figure 4).…”

Section: Resultsmentioning

confidence: 99%

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Prognostic significance of ankle brachial pressure index: A systematic review and meta-analysis

et al. 2016

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Purpose To synthesize and quantify the excess risk of morbidity and mortality in individuals with low ankle-brachial pressure index. Methods Electronic databases were searched to identify studies investigating morbidity and mortality outcomes in individuals undergoing ankle-brachial pressure index measurement. Meta-analysis of the outcomes was performed using fixed- or random-effects models. Uncertainties related to varying follow-up periods among the studies were resolved by meta-analysis of time-to-event outcomes. Results Forty-three observational cohort studies, enrolling 94,254 participants, were selected. A low ankle-brachial pressure index (<0.9) was associated with a significant risk of all-cause mortality (risk ratio: 2.52, 95% CI 2.26-2.82, P < 0.00001); cardiovascular mortality (risk ratio: 2.94, 95% CI 2.72-3.18, P < 0.00001); cerebrovascular event (risk ratio: 2.17, 95% CI 1.90-2.47, P < 0.00001); myocardial infarction (risk ratio: 2.28, 95% CI 2.07-2.51, P < 0.00001); fatal myocardial infarction (risk ratio: 2.81, 95% CI 2.33-3.40, P < 0.00001); fatal stroke (risk ratio: 2.28, 95% CI 1.80-2.89, P < 0.00001); and the composite of myocardial infarction, stroke, and death (risk ratio: 2.29, 95% CI 1.87-2.81, P < 0.00001). Similar findings resulted from analyses of individuals with asymptomatic PAD, individuals with cardiovascular or cerebrovascular co-morbidity, and patients with diabetes. Conclusions A low ankle-brachial pressure index is associated with an increased risk of subsequent cardiovascular and cerebrovascular morbidity and mortality. Randomised controlled trials are required to investigate the effectiveness of screening for PAD in asymptomatic and undiagnosed individuals and to evaluate benefits of early treatment of screen-detected PAD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prognostic significance of ankle brachial pressure index: A systematic review and meta-analysis

et al. 2016

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Systematic review of associations between concomitant rheumatoid arthritis and peripheral arterial disease, health-related quality of life and functional capacity

Zoubi

Hendry

2022

Rheumatol Int

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Patients with rheumatoid arthritis (RA) are at an increased risk of cardiovascular disease and vascular morbidity. The association between peripheral arterial disease (PAD) and RA has not been previously investigated within the scope of a review. Conjoined disease manifestations may impact patient well-being, perpetuating increased mortality and quality of life deficits. To investigate the association between RA and PAD, along with RA and the ankle-brachial pressure index (ABPI), the impact of disease concomitance on health-related quality of life (HRQOL) and functional capacity (FC) was also investigated. Individual study appraisal was completed using the Crowe Critical Appraisal Tool (CCAT). A level of evidence analysis was conducted using the American Society of Plastic Surgeons (ASPS) Evidence Rating Scale for Prognostic/Risk Studies. AMED®, CINAHL®, Health Source: Nursing/Academic Edition, MEDLINE®, AHFS®, Scopus, Web of Science, Cochrane Library and Google scholar. Ten studies produced a CCAT rating of ≥ 30 (75%) and were deemed high quality, while a single study demonstrated a score of 26 (65%) suggesting moderate quality. A grade “II” levels of evidence was awarded to positive association between RA and PAD. A gradation of “I” was awarded to the association between ABPI and RA. The impact of concomitant manifestations on HRQOL and FC did not qualify for a level of evidence analysis. The systematic inflammatory nature of RA likely contributes to the increased incidence of PAD within the population. Further investigations are required to ascertain the impact of conjoined disease manifestations on HRQOL and FC.

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Toe systolic pressures and toe-brachial indices

Trevethan

2019

Blood Pressure Monitoring

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Associations of symptomatic or asymptomatic peripheral arterial disease with all-cause mortality and cardiovascular mortality

Cited by 4 publications

References 20 publications

Prognostic significance of ankle brachial pressure index: A systematic review and meta-analysis

Prognostic significance of ankle brachial pressure index: A systematic review and meta-analysis

Systematic review of associations between concomitant rheumatoid arthritis and peripheral arterial disease, health-related quality of life and functional capacity

Toe systolic pressures and toe-brachial indices

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