Systematic review of associations between concomitant rheumatoid arthritis and peripheral arterial disease, health-related quality of life and functional capacity

Abstract

Patients with rheumatoid arthritis (RA) are at an increased risk of cardiovascular disease and vascular morbidity. The association between peripheral arterial disease (PAD) and RA has not been previously investigated within the scope of a review. Conjoined disease manifestations may impact patient well-being, perpetuating increased mortality and quality of life deficits. To investigate the association between RA and PAD, along with RA and the ankle-brachial pressure index (ABPI), the impact of disease concomitance on health-related quality of life (HRQOL) and functional capacity (FC) was also investigated. Individual study appraisal was completed using the Crowe Critical Appraisal Tool (CCAT). A level of evidence analysis was conducted using the American Society of Plastic Surgeons (ASPS) Evidence Rating Scale for Prognostic/Risk Studies. AMED®, CINAHL®, Health Source: Nursing/Academic Edition, MEDLINE®, AHFS®, Scopus, Web of Science, Cochrane Library and Google scholar. Ten studies produced a CCAT rating of ≥ 30 (75%) and were deemed high quality, while a single study demonstrated a score of 26 (65%) suggesting moderate quality. A grade “II” levels of evidence was awarded to positive association between RA and PAD. A gradation of “I” was awarded to the association between ABPI and RA. The impact of concomitant manifestations on HRQOL and FC did not qualify for a level of evidence analysis. The systematic inflammatory nature of RA likely contributes to the increased incidence of PAD within the population. Further investigations are required to ascertain the impact of conjoined disease manifestations on HRQOL and FC.

Genetic association between immune-mediated inflammatory diseases and peripheral artery disease: A Mendelian Randomization Study

“…In addition, they also speculated that the degree of peripheral arterial impairment was correlated to the severity of RA. A systematic review involving 11 observational studies suggested RA was an independent risk factor for PAD, and the disease manifestations of greater severity increased RA patients' susceptibility to PAD development [31] , which was consistent with Rinco´n's study. Our MR ndings aligned with previous studies, supporting a causal relationship between RA and increased risk of PAD.…”