Associations of serum uric acid level with diabetic retinopathy and albuminuria in patients with type 2 diabetes mellitus

Hou, Lin; Shi, Yingzhou; Wang, Sichao; Chen, Qing; Qiu, Li; Zhao, Meng; Zhou, Xinjie

doi:10.1177/0300060520963980

Cited by 15 publications

(13 citation statements)

References 34 publications

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“…However, no significant difference was reported between the two groups. Hou et al, (2020) indicated that the higher levels of SUA (Q3 and Q4) were associated with greater risk for diabetic retinopathy, compared with the lower level (Q1) (odds ratio [OR]: 3.056, 95% confidence interval [CI]: 1.506–6.198; OR: 3.417, 95% CI: 1.635–7.139, respectively) [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

et al. 2022

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Background Diabetic peripheral neuropathy (DPN) is one of the most common chronic microvascular complications in type 2 diabetes mellitus (T2DM). Hence, the present study aimed to investigate the association between Serum Uric Acid (SUA) levels and diabetic peripheral polyneuropathy in patients with type 2 diabetes. Methods We performed this case–control study during 2019–2020 on individuals with diabetes referring to the Razi clinic of Rasht, in the north of Iran. Polyneuropathy in patients was assessed based on the Neuropathy Disability Score (NDS), Diabetic neuropathy symptom score (DNS) scoring system, and electromyography (EMG)/nerve conduction velocity (NCV). The inclusion criterion for the control group was normal EMG/NCV. Then, the patients were assessed for SUA level and also laboratory results. Results In total, 230 patients with type 2 diabetes were examined. The mean SUA level in the DPN group was significantly higher compared to the control group (6.72 ± 1.75 vs. 4.57 ± 1.49 mg/dL). With increasing the SUA, the odds of developing neuropathy increased by 2.2 times (OR = 2.2). The risk factors for diabetic polyneuropathy included gender (male) (OR = 0.347), SBP (OR = 1.1), retinopathy (OR = 3.29), and microalbuminuria (OR = 4.44). The chance of developing polyneuropathy in patients with retinopathy was 3.3 times higher than in the control group, it was 4.4 times in microalbuminuria patients. Conclusion Elevated SUA level increased the chance of developing peripheral polyneuropathy in a person with type 2 diabetes. SUA levels higher than 5.25 mg / dL expose a person with type 2 diabetes to developing peripheral polyneuropathy.

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Section: Discussionmentioning

confidence: 99%

The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

et al. 2022

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“…10 Serum UA levels are independently associated with an increased risk of diabetic peripheral neuropathy in T2DM patients, 11 and it may predict the development of diabetic retinopathy and diabetic nephropathy. 12,13 UA levels are related to dietary factors and reflect dietary intake to a certain extent. 14 Potential pathophysiology and prescribed dietary patterns lead to nutritional deficiency and imbalance in T2DM patients.…”

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confidence: 99%

Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

Liu¹,

Wang²,

Zhao³

et al. 2021

IJGM

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Objective: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM). Methods: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS). Results:The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (P<0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was <4.17 mg/dl (β 0.12,95% CI −0.04, 0.28; P=0.121) and decreased when UA was >4.17 mg/dl (β −0.38,95% CI −0.64, −0.12; P=0.004). Conclusion:This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.

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“…Similarly Chen D et al [20] in their study males were comparatively more than the females. Hou L et al [21] also concluded similar finding.…”

Section: Discussionmentioning

confidence: 53%

“…Jianfei Xia et al [18] In their study the mean age was 56.20 ± 6.22 years similar to this study. Kiani J et al [19] in their study the mean age of the patients in the case group was 54.6±6.9 and in the control group was 55.8±5.8 years (p=0.389).Chen D et al [20] in their study total number of patients were divided into 3 groups among which NDR group the age was 49.2 ± 8.5, in group NPDR the age was 52.1 ± 13.1 and in group PDR age was 53.5 ± 10.1.Hou L et al [21] in their study included 389 patients with type 2 DM (238 men [61.2%] and 151 women [38.8%]; mean age, 57.93 11.41 years.…”

Section: Discussionmentioning

confidence: 90%

A prospective study to determine association between serum uric acid and diabetic retinopathy

Sanghai¹,

Abrar²,

Malik³

2021

Int. J. Med. Ophthalmol.

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To explore the role of serum uric acid (SUA) concentration in diabetic retinopathy (DR) for patients with type 2 diabetes mellitus (T2DM). Methods: The present prospective observational study was conducted in department of Ophthalmology at Chattrapati Shivaji Subharti hospital from December 2019 to November 2020. The diabetic patients were assigned to one of the following groups based on presence and severity of diabetic retinopathy with the help of fundus photographs and/or fundus fluorescein angiography. Results: On correlation analysis, it was found that there is significant relationship between Serum Uric Acid and fundus grading of diabetic retinopathy as r=.310 and p <0.016. On regression analysis, the model summary states that 9.6% variation can be explained by serum uric acid on fundus grade as R square =.096 with P=.016 and hence regression model is significant.

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Associations of serum uric acid level with diabetic retinopathy and albuminuria in patients with type 2 diabetes mellitus

Cited by 15 publications

References 34 publications

The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

A prospective study to determine association between serum uric acid and diabetic retinopathy

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