Background Diabetic peripheral neuropathy (DPN) is one of the most common chronic microvascular complications in type 2 diabetes mellitus (T2DM). Hence, the present study aimed to investigate the association between Serum Uric Acid (SUA) levels and diabetic peripheral polyneuropathy in patients with type 2 diabetes. Methods We performed this case–control study during 2019–2020 on individuals with diabetes referring to the Razi clinic of Rasht, in the north of Iran. Polyneuropathy in patients was assessed based on the Neuropathy Disability Score (NDS), Diabetic neuropathy symptom score (DNS) scoring system, and electromyography (EMG)/nerve conduction velocity (NCV). The inclusion criterion for the control group was normal EMG/NCV. Then, the patients were assessed for SUA level and also laboratory results. Results In total, 230 patients with type 2 diabetes were examined. The mean SUA level in the DPN group was significantly higher compared to the control group (6.72 ± 1.75 vs. 4.57 ± 1.49 mg/dL). With increasing the SUA, the odds of developing neuropathy increased by 2.2 times (OR = 2.2). The risk factors for diabetic polyneuropathy included gender (male) (OR = 0.347), SBP (OR = 1.1), retinopathy (OR = 3.29), and microalbuminuria (OR = 4.44). The chance of developing polyneuropathy in patients with retinopathy was 3.3 times higher than in the control group, it was 4.4 times in microalbuminuria patients. Conclusion Elevated SUA level increased the chance of developing peripheral polyneuropathy in a person with type 2 diabetes. SUA levels higher than 5.25 mg / dL expose a person with type 2 diabetes to developing peripheral polyneuropathy.
Background: Diabetes is one of the most common and costly chronic diseases with an increasing prevalence in all around the world. On the other hand, the relationship between Uric Acid (UA) level and glycemic index in type 2 diabetic patients is not clear. Objective: The aim of this study is to evaluate the UA level and glycemic status of type 2 diabetic patients. Methods: A total of 230 patients with type 2 diabetes were studied in this cross-sectional study, who referred to Razi and Besat clinics in 2020. Researcher-made checklist were used to collect demographic and clinical data includes age, sex, duration of the disease, body mass index (BMI), fasting blood sugar (FBS), Cholesterol, Triglyceride (TG), high density lipid (HDL), low density lipid (LDL), Hemoglobin A1C (HbA1c), UA, Creatinine (Cr) level, history of heart disease, blood pressure, and a history of smoking. The results were analyzed using IBM SPSS Statistics version 26. Results: The results showed that there was a marginally significant relationship between UA and HbA1C (r = 0.318, P<0.001), Cr (r = 0.351, P<0.001) and Triglyceride (TG) (r = 0.174, P=0.008). Conclusion: Generally, in patients with type 2 diabetes, serum UA level has an adverse effect on glycemic status.
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