Associations of Proatrial Natriuretic Peptide with Components of the Metabolic Syndrome in Adolescents and Young Adults from the General Population

Goharian, Tina S; Goetze, Jens P.; Faber, Jens; Andersen, Lars Bo; Grøntved, Anders; Jeppesen, Jørgen

doi:10.1093/ajh/hpx026

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…Nevertheless, other studies have found associations between copeptin and the metabolic factors related to IR in children and adolescents [18][19][20], but the associations found have overall been less consistent compared with the studies in adults [2][3][4][5][6][7][8]. We have no obvious explanation for this age-related discrepancy, but it is important in this connection that the well described negative association between insulin and IR and the natriuretic peptide system could not be found among our adolescents, either [39], and that others have also found that age modulates the association of copeptin with IR [40]. Accordingly, in a family-based crosssectional study, the association between copeptin and IR could only be found among the middle-aged and elderly but not among the younger adults [40].…”

Section: Adolescents Versus Young Adultscontrasting

confidence: 88%

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

et al. 2019

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surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress. Peptides, 115,[8][9][10][11][12][13][14] Dette er siste tekst-versjon av artikkelen, og den kan inneholde små forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du her: http://dx. ABSTRACTIn middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were logtransformed. Among the young adults, copeptin associated with IR (B (95%CI) =0.19 (0.11 to 0.27), P<0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P=0.78). MDI score associated with IR (B=0.010 (0.004 to 0.016), P<0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.

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Section: Adolescents Versus Young Adultscontrasting

confidence: 88%

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

et al. 2019

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“…Twenty-seven studies 20,21,24–26,31–34,38,39,41,43,48,49,51,54–58,60–64,66 reported the association between cardiac NPs and TC, for a total of 43428 subjects evaluated. Twenty-eight studies 20–25,27–30,32–34,37–39,44,45,51,52,55–57,59,61,63,64,66 reported the association between cardiac NPs and LDLc, for a total of 44829 subjects evaluated. Thirty-six studies 20,21,24–26,31–34,38,39,41,43,48,49,51,54–58,60–64,66 reported the association between cardiac NPs and HDLc, for a total of 49951 subjects evaluated.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-six studies 20,21,24–26,31–34,38,39,41,43,48,49,51,54–58,60–64,66 reported the association between cardiac NPs and HDLc, for a total of 49951 subjects evaluated. Thirty-nine studies 20–30,32–42,44–47,50–57,59–64 reported the association between cardiac NPs and TG, for a total of 39649 subjects evaluated. All the components of lipid profile was associated with NPs.…”

Section: Resultsmentioning

confidence: 99%

Association Between Cardiac Natriuretic Peptides and Lipid Profile: a Systematic Review and Meta-Analysis

Spannella

Giulietti

Bordicchia

et al. 2019

Sci Rep

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Cardiac natriuretic peptides (NPs) play a fundamental role in maintaining cardiovascular (CV) and renal homeostasis. Moreover, they also affect glucose and lipid metabolism. We performed a systematic review and meta-analysis of studies investigating the association of NPs with serum lipid profile. A PubMed and Scopus search (2005–2018) revealed 48 studies reporting the association between NPs and components of lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and triglycerides (TG)]. Despite high inconsistency across studies, NPs levels were inversely associated with TC [k = 32; pooled r = −0.09; I2 = 90.26%], LDLc [k = 31; pooled r = −0.09; I2 = 82.38%] and TG [k = 46; pooled r = −0.11; I2 = 94.14%], while they were directly associated with HDLc [k = 41; pooled r = 0.06; I2 = 87.94%]. The relationship with LDLc, HDLc and TG lost significance if only studies on special populations (works including subjects with relevant acute or chronic conditions that could have significantly affected the circulating levels of NPs or lipid profile) or low-quality studies were taken into account. The present study highlights an association between higher NP levels and a favorable lipid profile. This confirms and extends our understanding of the metabolic properties of cardiac NPs and their potential in CV prevention.

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“…Natriuretic peptides inhibit pathways involved in inflammation and attenuate the production of proinflammatory cytokines by macrophages and adipocytes. 179,227 Importantly, circulating levels of natriuretic peptides are decreased in obesity, diabetes, metabolic syndrome and non-alcoholic fatty liver disease, particularly in women [228][229][230][231] ; in addition, these disorders are accompanied by impaired responsiveness to the actions of natriuretic peptides in adipose tissue, blood vessels and the kidney. [232][233][234] The impairment of natriuretic peptide signalling may be related to an increase in neprilysin that is seen in states of visceral adiposity 185 ; enhanced neprilysin activity has been implicated in the end-organ injury seen in diabetes.…”

Section: Role Of Aldosterone Leptin and Natriuretic Peptides In The mentioning

confidence: 99%

Characterization of the inflammatory‐metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution and potential treatment of the disease

Packer

Lam

Lund

et al. 2020

European J of Heart Fail

110

109

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Accumulating evidence points to the existence of an inflammatory-metabolic phenotype of heart failure with a preserved ejection fraction (HFpEF), which is characterized by biomarkers of inflammation, an expanded epicardial adipose tissue mass, microvascular endothelial dysfunction, normal-to-mildly increased left ventricular volumes and systolic blood pressures, and possibly, altered activity of adipocyte-associated inflammatory mediators. A broad range of adipogenic metabolic and systemic inflammatory disorders-e.g. obesity, diabetes and metabolic syndrome as well as rheumatoid arthritis and psoriasis-can cause this phenotype, independent of the presence of large vessel coronary artery disease. Interestingly, when compared with men, women are both at greater risk of and may suffer greater cardiac consequences from these systemic inflammatory and metabolic disorders. Women show disproportionate increases in left ventricular filling pressures following increases in central blood volume and have greater arterial stiffness than men. Additionally, they are particularly predisposed to epicardial and intramyocardial fat expansion and imbalances in adipocyte-associated proinflammatory mediators. The hormonal interrelationships seen in inflammatory-metabolic phenotype may explain why mineralocorticoid receptor antagonists and neprilysin inhibitors may be more effective in women than in men with HFpEF. Recognition of the inflammatory-metabolic phenotype may improve an understanding of the pathogenesis of HFpEF and enhance the ability to design clinical trials of interventions in this heterogeneous syndrome.

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Associations of Proatrial Natriuretic Peptide with Components of the Metabolic Syndrome in Adolescents and Young Adults from the General Population

Abstract: The young adults displayed significant negative associations between MR-proANP and several components of the metabolic syndrome, whereas such associations were not found among the adolescents besides triglycerides and diastolic BP.

Cited by 13 publications

References 40 publications

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

Association Between Cardiac Natriuretic Peptides and Lipid Profile: a Systematic Review and Meta-Analysis

Characterization of the inflammatory‐metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution and potential treatment of the disease

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