Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study

Arrebola, Juan Pedro; Ramos, Juan José; Bartolomé, Mónica; Esteban, Marta; Huetos, Olga; Cañas, Ana; López-Herranz, Ana; Calvo, Eva; Pérez‐Gómez, Beatriz; Castaño, Argelia

doi:10.1016/j.envint.2018.12.030

Cited by 44 publications

(22 citation statements)

References 66 publications

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“…Gaikwad et al [24] also showed that the level of UA also increased in pesticide applicators, compared to a control group. According to Arrebola et al [25], organochlorine pesticides such as γ-HCH and o, p -DDE have been associated with hyperuricemia. In Clarias batrachus fish, exposure to the pesticides carbaryl and phorate led to a significant increase in urea, uric acid and creatinine levels [26].…”

Section: Discussionmentioning

confidence: 99%

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Bayili

Da²,

Ilboudo

et al. 2020

GSC Biol. and Pharm. Sci.

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Repeated exposure to pesticides can cause a variety of human health problems, particularly among farmers. This work consisted in studying biochemical parameters and their evolution in cotton farmers exposed to pesticides. A longitudinal study was conducted during and after the 2018/2019 cotton season on a cohort of cotton farmers around the Bala hippopotamus pond in the department of Satiri. Biochemical parameters were measured during and after the crop year on the Architect ci 4100. The majority of the farmers had high uric acid (UA) and low blood sugar (Gluc) concentrations. A few had concentrations of Cholinesterase (ChE) (6.19%); Direct Bilirubin (BilD) (23.01%); Gamma Glutamyl Transferase (GGT) (8.85%); Alkaline Phosphatase (ALkP) (4.42%); Cholesterol (Chol) (4.42%); triglycerides (Trig) (4.42%); aspartate aminotransferase (AST) (4.42%) higher than normal and lower than normal albumin (Alb) (13.27%) and total protein (TP) (13.27%) concentrations. Analysis of the evolution of biochemical parameters showed that none of the producers had higher than normal ChE and TP concentrations. After the campaign, the number of producers with lower than normal values increased for AST, AlkP, Alb and Urea while those with higher than normal values increased for GGT, UA, Gluc, Chol, Trig and BilD. Also, a significant decrease in AST, ALT and creatinine (CreaC) concentrations and a significant increase in GGT and BilD concentrations were observed. The existence of some disturbances of biochemical parameters in farmers should encourage to test the hypothesis of a link between pesticide exposure and the appearance of biochemical disorders in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Bayili

Da²,

Ilboudo

et al. 2020

GSC Biol. and Pharm. Sci.

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“…Three studies have examined the association between blood/urine cadmium and HU so far (Arrebola et al 2019;Sun et al 2017). Studies in Spain and China found a positive association between blood/urine cadmium and HU (Arrebola et al 2019;Sun et al 2017). However, no association between blood cadmium and HU was found in the USA (Krishnan et al 2012).…”

Section: Cadmium Intake and Humentioning

confidence: 99%

“…Recent studies suggest that cadmium is associated with diabetes and chronic kidney disease (CKD) in the Chinese population (Shi et al 2018a). A limited number of studies have examined the association between blood/urine cadmium and HU with inconsistent findings (Arrebola et al 2019;Jung et al 2019;Krishnan et al 2012;Sun et al 2017). Data from the National Health and Nutrition Examination Survey (NHANES) suggested a null association between blood cadmium and HU (Krishnan et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Data from the National Health and Nutrition Examination Survey (NHANES) suggested a null association between blood cadmium and HU (Krishnan et al 2012). In Spain, urine cadmium was found to be positively associated with HU (Arrebola et al 2019). A regional study from China found that blood cadmium was associated with an increased likelihood of having HU in men but not in women (Sun et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Cadmium Intake, Dietary Patterns and Hyperuricemia Among Adults in China

Shi

2020

Expo Health

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Blood and urine cadmium levels have been found to be positively associated with hyperuricemia (HU) in some studies. Few studies have examined the association between dietary cadmium intake, dietary patterns and HU in the Chinese population. The study analysed data from 8429 adults who participated in the China Health and Nutrition Survey (CHNS). Dietary intake was assessed by 3-day 24 h food record in seven waves of survey (

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“…Persistent organic pollutants (POPs) are a large group of carbon-based compounds which have a high lipophilicity and low water solubility (1,2). Additionally, they are highly resistant to degradation, which leads to an accumulation in the environment and a biomagnification along the food chain (3,4). POPs include a wide range of compounds such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), polybrominated diphenyl ethers (PBDEs), and per-and polyfluoroalkyl substances (PFAS), among others (5).…”

Section: Introductionmentioning

confidence: 99%

Concentrations of persistent organic pollutants in blood of the Spanish population: Temporal trend

González¹,

Domingo²

2021

Arhiv za farmaciju

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The present article reviews the human biomonitoring studies conducted in Spain to assess exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), polybrominated diphenyl ethers (PBDEs), and per- and poly-fluoroalkyl substances (PFAS). In general terms, important variations in POPs concentrations between Spanish regions and specific populations were observed, while no associations between exposure to POPs and adverse health outcomes were found. Moreover, occupational exposure seems not to be a risk factor with regards to POPs exposure in the Spanish population. The present review highlights the importance of conducting human biomonitoring studies to find possible associations between POPs and adverse health effects.

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Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study

Cited by 44 publications

References 66 publications

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Cadmium Intake, Dietary Patterns and Hyperuricemia Among Adults in China

Concentrations of persistent organic pollutants in blood of the Spanish population: Temporal trend

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