Associations of Acrylamide Intake with Circulating Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women

Nagata, Chisato; Konishi, Kie; Tamura, Takashi; Wada, Keiko; Tsuji, Michiko; Hayashi, Makoto; Takeda, Noriyuki

doi:10.1158/1055-9965.epi-14-0935

Cited by 28 publications

(18 citation statements)

References 31 publications

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“…Hogervorst et al reported that the hemoglobin adduct concentration of acrylamide was positively associated with estrogen concentration in premenopausal American women whose BMI was <25. In contrast, Nagata et al showed that dietary acrylamide intake assessed by FFQ was negatively related to estrogen concentration among premenopausal Japanese women. In a nested case‐control study by Olesen et al, the hemoglobin adduct concentration of acrylamide was positively associated with the risk of ER+ breast cancer in smokers.…”

Section: Discussionmentioning

confidence: 90%

Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Kotemori¹,

Ishihara

Zha

et al. 2018

Cancer Science

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Acrylamide forms during cooking and is classified as a probable carcinogen in humans, mandating the need for epidemiological studies of dietary acrylamide and cancers. However, the risk of dietary acrylamide exposure to breast cancer in Japanese women has not been assessed. We investigated the association between dietary acrylamide intake and risk of breast cancer in the Japan Public Health Center‐based Prospective Study. The present study included 48 910 women aged 45‐74 years who responded to a 5‐year follow‐up survey questionnaire. Dietary acrylamide intake was assessed using a validated food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios and 95% confidence intervals. During an average of 15.4 years of follow up, 792 breast cancers were diagnosed. Energy‐adjusted dietary acrylamide intake was not associated with the risk of breast cancer (adjusted hazard ratio for highest versus lowest tertile = .95, 95% confidence intervals: 0.79‐1.14, P‐trend = .58). Further, no significant associations were observed when stratified analyses were conducted by smoking status, coffee consumption, alcohol consumption, body mass index, menopausal status, estrogen receptor status, and progesterone receptor status. In conclusion, dietary acrylamide intake was not associated with the risk of breast cancer in this population‐based prospective cohort study of Japanese women.

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Section: Discussionmentioning

confidence: 90%

Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Kotemori¹,

Ishihara

Zha

et al. 2018

Cancer Science

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“…Tobacco is one of the most important sources of acrylamide, and it is well-established that cigarette smoke influences Hb-adducts levels (smokers have mean HbAA levels at least three to four times higher than non-smokers) [11, 14]. Moreover, it has been hypothesized that acrylamide may influence hormonal homeostasis [40–42]. Thus, the present study was designed to reduce confounding by these factors, and only those women who reported being postmenopausal and never smokers were included in the study.…”

Section: Discussionmentioning

confidence: 99%

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

et al. 2016

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Purpose Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from 8 countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by HPLC/MS/MS (high-performance liquid chromatography/tandem mass spectrometry). In this cross-sectional analysis four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA+HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA), and all independent variables were log-transformed (log2) to improve normality. Median (25th-75thpercentile) HbAA and HbGA adducts levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. Results The main food group determinants of HbAA, HbGA, HbAA+HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA explained in this study was 30%, 26%, 29%, and 13%, respectively. Conclusions Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.

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“…One possible mechanism by which dietary acrylamide exerts its carcinogenic effect is thought to be via the genotoxic pathway of glycidamide, which is an acrylamide metabolite . Furthermore, a hormone‐related pathway has also been debated . Thus, acrylamide is more likely to cause a non‐negligible increase in the risk of endometrial and ovarian cancers through synergistic genotoxicity effects and hormone changes than with other cancers.…”

Section: Introductionmentioning

confidence: 99%

Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women

Kotemori¹,

Ishihara

Zha

et al. 2018

Cancer Science

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A meta‐analysis published in 2015 noted a marginally increased risk of endometrial and ovarian cancers in non‐smoking women with dietary acrylamide intake, but only a few studies were included, and they were limited to Western countries. The aim of this study was to investigate the association between dietary acrylamide intake and endometrial or ovarian cancer risk in the Japan Public Health Center‐based Prospective Study (JPHC Study). In this prospective cohort study, 47 185 participants aged 45‐74 years at the follow‐up starting point in the JPHC Study were enrolled. Dietary acrylamide intake was assessed using a validated food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI). In participants with endometrial and ovarian cancer, the average follow‐up periods were 15.5 and 15.6 years, respectively, and 161 and 122 cases of endometrial and ovarian cancer were diagnosed, respectively. Energy‐adjusted dietary acrylamide intake was negatively associated with endometrial cancer, but the association disappeared after adjusting for coffee consumption with an adjusted HR for the highest vs lowest tertile of 0.85 (95%CI: 0.54‐1.33). No association was observed, however, for ovarian cancer (adjusted HR, 0.77; 95%CI: 0.49‐1.23). Furthermore, after stratifying by smoking status, coffee consumption, alcohol consumption, body mass index, and menopause status, no association was observed. Dietary acrylamide intake was not associated with the risk of endometrial or ovarian cancer in Japanese women with a relatively lower dietary intake of acrylamide compared with Western populations.

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Associations of Acrylamide Intake with Circulating Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women

Cited by 28 publications

References 31 publications

Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women

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