Associations between various possible promoter polymorphisms of MMPs genes and endometriosis risk: a meta-analysis

Yang, Huijun; Liu, Jiaojing; Fan, Yuanyuan; Guo, Qinghui; Ge, Li; Yu, Na; Zheng, Xuan; Yu, Dou; Zheng, Shicun

doi:10.1016/j.ejogrb.2016.08.015

Cited by 22 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although EM is a kind of benign tumor, it has attracted the attention of experts and scholars worldwide due to its biological characteristics, such as metastasis, development, implantation, erosion, tissue destruction and potential malignant transformation (12). Moreover, its pathogenesis is complex and not fully understood, which is currently believed to be related to a variety of bioactive factors, such as genetic material, steroid hormones, environmental factors and immune molecules (13,14). …”

Section: Discussionmentioning

confidence: 99%

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Sui

Sun

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Expression of autophagy-related proteins, microtubule-associated protein light chain 3 (LC3) and Beclin1, and matrix metalloproteinase-2 (MMP-2) was investigated in serum and peritoneal fluid of patients with endometriosis (EM). The messenger ribonucleic acid (mRNA) expression levels of MMP-2, LC3 and Beclin1 in endometrial tissues of EM patients and correlation of these genes with EM and their significance were evaluated. The serum, peritoneal fluid and endometrial tissues of 84 patients treated in The First Affiliated Hospital of Qiqihar Medical University (Qiqihar, China) from March 2016 to March 2017 were collected. The serum, peritoneal fluid and endometrial tissues of 42 EM patients were used as the experimental group, while those of 42 non-EM patients were used as the control group. The levels of LC3, Beclin1 and MMP-2 in serum and peritoneal fluid of EM patients and non-EM patients were quantitatively detected via enzyme-linked immunosorbent assay (ELISA), followed by comparative analysis based on data in both groups. In addition, mRNA expression of LC3, Beclin1 and MMP-2 in the endometrium in both groups were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and differences in expression of these genes between the groups were analyzed and evaluated. Correlation of LC3, Beclin1 and MMP-2 with EM was explored. Results of ELISA showed that levels of LC3 and Beclin1 in the EM group were significantly lower than those in the control group, while levels of MMP-2 in serum and peritoneal fluid of the EM group were significantly higher than those in the control group (P<0.05). Results of RT-qPCR revealed that mRNA expression of LC3 and Beclin1 in the endometrium of patients in the EM group were obviously decreased compared with those in the control group, while the expression of MMP-2 was high, and differences in expression were statistically significant (P<0.05). The expression of MMP-2 is high, and expression of LC3 and Beclin1 is low in serum, peritoneal fluid and endometrium of EM patients, and investigating the expression of MMP-2, LC3 and Beclin1 in EM is helpful to further clarify the pathogenesis of EM, and guide the clinical diagnosis and treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Sui

Sun

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…The many observations in women with endometriosis can be interpreted as the expression of predisposition and/or as the consequence of endometriosis instead of being the cause. These comprise abundant retrograde menstruation (194) and the recent observations on cellular pathways (195), cytokines (196)(197)(198)(199), dentritic cells (200), vitamin D (201), mast cells (202,203), hypoxia-inducible factor (204), high Mobility Group Box-1 and Toll-Like Receptor 4 (205), matrix metalloproteinase promoter polymorphisms (206), galectin-3 expression (207), promoter polymorphisms of matrix metalloproteinase genes (208), P receptor (PR) expression (209), acylcarnitines, phosphatidylcholines, and sphingomyelins in PF (210), uterine leukocytes (96), vascular epithelial growth factor (211,212), and other angiogenic factors (213) such as the TGF-b superfamily (214), vezatin expression (215), lymphocytes in blood (216), prostaglandins (217), insulin-like growth factor I (IGF-I) (218), repeated micro-trauma (219) or macro-trauma (63), transcription-3 signaling (220), genetic variants expression (221), and the Hoxa10/HOXA10 gene (222).…”

Section: Figurementioning

confidence: 99%

Pathogenesis of deep endometriosis

Gordts

Koninckx²,

Brosens

2017

Fertility and Sterility

174

110

View full text Add to dashboard Cite

“…Numerous factors are involved in endometriosis-associated angiogenesis including matrix metalloproteinases (MMPs), TNF- ɑ , cyclo-oxygenase (COX), and hypoxia-inducible factor 1 α (HIF-1). MMPs degrade the extracellular matrix and are key components of endometrial adhesion and angiogenesis [ 26 , 27 ]. TNF- ɑ promotes angiogenesis during the progression of endometriosis.…”

Section: Resultsmentioning

confidence: 99%

Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Zheng

Cao²,

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogenic effects have been investigated, and the molecular basis underlying their therapeutic effects in endometriosis has been explored. This review aims to describe natural products and compounds that suppress angiogenesis associated with endometriosis and to assess their diverse molecular mechanisms of action. Furthermore, this review provides a source of information relating to alternative and complementary therapeutic products that mediate anti-angiogenesis. An extensive review of the literature and electronic databases, such as the China National Knowledge Infrastructure, PubMed, and Embase, was conducted using the keywords ‘endometriosis,' ‘traditional Chinese medicine,' ‘Chinese herbal medicine,' ‘natural compounds,' and ‘anti-angiogenic' therapy. Anti-angiogenic therapy is an emerging strategy for the treatment of endometriosis. Natural anti-angiogenic products and Chinese medicines provide several beneficial clinical effects, including pain relief. In this review, we summarize clinical trials and experimental studies of endometriosis using natural products and Chinese medicines. In particular, we focus on anti-angiogenic products and alternative and complementary medicines for the treatment of endometriosis and additionally examine their therapeutic efficacy and mechanisms of action. Anti-angiogenic natural products and/or compounds provide a new approach for the treatment of endometriosis. Future work will require randomized trials with larger numbers of subjects, as well as long-term follow-up to confirm the findings described here.

show abstract

Associations between various possible promoter polymorphisms of MMPs genes and endometriosis risk: a meta-analysis

Cited by 22 publications

References 32 publications

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Pathogenesis of deep endometriosis

Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Contact Info

Product

Resources

About