Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis

Lin, Zhongjing; Huang, Shouyue; Sun, Jun; Xie, Bing; Zhong, Yisheng

doi:10.1155/2019/6707650

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…TLR4 gene rs4986790 polymorphism confers different susceptibility on various diseases. A number of studies have shown that TLR4 rs4986790 polymorphism is associated with risk of multiple diseases such as pneumonia, open angle glaucoma, cancer, Type 2 diabetes and Inflammatory Bowel Disease 21 , 22 , 23 , 24 . And TLR4 rs4986790 polymorphism is not associated with risk of asthma, coronary artery disease, atherosclerosis or preeclampsia 25 , 26 , 27 , 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Nurses are the largest health care practitioners and through their care activities can apply the results of genetic laboratory research to clinical applications. Health education is an important way 22 . Change bad living habits, such as smoking, drinking, high‐salt and high‐fat diet, lack of exercise, etc., and cultivate scientific harmony and Rational life style is an important content of hypertension health education.…”

Section: Discussionmentioning

confidence: 99%

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TLR4 rs4986790 polymorphism confers risk to Helicobacter pylori infection in Zhejiang, China and its enlightenment to nursing care

Jiang

2022

Clinical Laboratory Analysis

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Purpose Previous literatures on the association between TLR4 gene rs4986790 polymorphism and Helicobacter pylori infection risk reported conflict results. We conducted a case‐control study and meta‐analysis to investigate whether TLR4 gene rs4986790 polymorphism confers risk to Helicobacter pylori infection. Patients and methods 254 patients with Helicobacter pylori positive and 235 patients with Helicobacter pylori negative were enrolled. PubMed, Embase, CNKI (Chinese national knowledge internet) were carefully searched and reviewed. Odds ratio (OR) together with 95% confidence interval (CI) were applied to calculate the association power. Results GG genotype of TLR4 gene rs4986790 polymorphism contributes increased risk to the population of Zhejiang, China ( p = 0.019). Meta‐analysis found that the positive findings came from Asian population by allele contrast ( p = 0.006), homozygote comparison ( p = 0.006) and recessive genetic model ( p = 0.001). Conclusion TLR4 gene rs4986790 polymorphism is associated with Helicobacter pylori infection risk for population of Zhejiang, China. Combined with individual gene polymorphism, the accuracy of risk assessment of Helicobacter pylori infection can be improved and individualized health education can be provided for patients with Helicobacter pylori infection by nurses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

TLR4 rs4986790 polymorphism confers risk to Helicobacter pylori infection in Zhejiang, China and its enlightenment to nursing care

Jiang

2022

Clinical Laboratory Analysis

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“…The connection of Toll like receptor-4 (TLR-4) and its ligand lipopolysaccharide (LPS) with IRI or glaucoma has been demonstrated in previous studies, showing that genetic deletion of TLR-4 is neuroprotective in IRI disorders ( 23 ). Furthermore, mutations on the TLR-4 correlated with altered susceptibility to primary open angle glaucoma and were even described as a possible bio-indicator ( 24 ).…”

Section: Methodsmentioning

confidence: 99%

Increased Hydrostatic Pressure Promotes Primary M1 Reaction and Secondary M2 Polarization in Macrophages

et al. 2020

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Patients with chronic anterior uveitis are at particularly high risk of developing secondary glaucoma when corticosteroids [e.g., dexamethasone (Dex)] are used or when inflammatory activity has regressed. Macrophage migration into the eye increases when secondary glaucoma develops and may play an important role in the development of secondary glaucoma. Our aim was to evaluate in vitro if increased hydrostatic pressure and corticosteroids could induce changes in macrophages phenotype. By using a pressure chamber cell culture system, we assessed the effect of increased hydrostatic pressure (HP), inflammation, and immunosuppression (Dex) on the M1/M2 phenotype of macrophages. Bone marrow-derived macrophages (BMDMs) were stimulated with medium, lipopolysaccharide (LPS, 100 ng/ml), Dex (200 ng/ml), or LPS + Dex and incubated with different HP (0, 20, or 60 mmHg) for 2 or 7 days. The numbers of CD86+/CD206− (M1 phenotype), CD86–/CD206+ (M2 phenotype), CD86+/CD206+ (intermediate phenotype), F4/80+/TNF-α+, and F4/80+/IL-10+ macrophages were determined by flow cytometry. TNF-α and IL-10 levels in cell culture supernatants were quantified by ELISA. TNF-α, IL-10, fibronectin, and collagen IV expression in BMDMs were detected by immunofluorescence microscopy. Higher HP polarizes macrophages primarily to an M1 phenotype (LPS, 60 vs. 0 mmHg, d2: p = 0.0034) with less extra cellular matrix (ECM) production and secondary to an M2 phenotype (medium, 60 vs. 0 mmHg, d7: p = 0.0089) (medium, 60 vs. 20 mmHg, d7: p = 0.0433) with enhanced ECM production. Dex induces an M2 phenotype (Dex, medium vs. Dex, d2: p < 0.0001; d7: p < 0.0001) with more ECM production. Higher HP further increased M2 polarization of Dex-treated macrophages (Dex, 60 vs. 0 mmHg, d2: p = 0.0417; d7: p = 0.0454). These changes in the M1/M2 phenotype by high HP or Dex treatment may play a role in the pathogenesis of secondary uveitic glaucoma- or glucocorticoid (GC)-induced glaucoma.

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“…Meanwhile, TLRs pathway induce glaucomatous neuroinflammation in two ways, either through polymorphism of TLR4 alleles [ 67 ] or increase in TLR4 protein expression in the retina of glaucoma animal models [ 68 ]. Different TLRs recognize different stimuli.…”

Section: Main Textmentioning

confidence: 99%

Nanoparticles for the treatment of glaucoma-associated neuroinflammation

et al. 2022

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Recently, a considerable amount of literature has emerged around the theme of neuroinflammation linked to neurodegeneration. Glaucoma is a neurodegenerative disease characterized by visual impairment. Understanding the complex neuroinflammatory processes underlying retinal ganglion cell loss has the potential to improve conventional therapeutic approaches in glaucoma. Due to the presence of multiple barriers that a systemically administered drug has to cross to reach the intraocular space, ocular drug delivery has always been a challenge. Nowadays, studies are focused on improving the current therapies for glaucoma by utilizing nanoparticles as the modes of drug transport across the ocular anatomical and physiological barriers. This review offers some important insights on the therapeutic advancements made in this direction, focusing on the use of nanoparticles loaded with anti-inflammatory and neuroprotective agents in the treatment of glaucoma. The prospect of these novel therapies is discussed in relation to the current therapies to alleviate inflammation in glaucoma, which are being reviewed as well, along with the detailed molecular and cellular mechanisms governing the onset and the progression of the disease.

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Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis

Cited by 4 publications

References 37 publications

TLR4 rs4986790 polymorphism confers risk to Helicobacter pylori infection in Zhejiang, China and its enlightenment to nursing care

TLR4 rs4986790 polymorphism confers risk to Helicobacter pylori infection in Zhejiang, China and its enlightenment to nursing care

Increased Hydrostatic Pressure Promotes Primary M1 Reaction and Secondary M2 Polarization in Macrophages

Nanoparticles for the treatment of glaucoma-associated neuroinflammation

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