TLR4 rs4986790 polymorphism confers risk to Helicobacter pylori infection in Zhejiang, China and its enlightenment to nursing care

Abstract

Purpose Previous literatures on the association between TLR4 gene rs4986790 polymorphism and Helicobacter pylori infection risk reported conflict results. We conducted a case‐control study and meta‐analysis to investigate whether TLR4 gene rs4986790 polymorphism confers risk to Helicobacter pylori infection. Patients and methods 254 patients with Helicobacter pylori positive and 235 patients with Helicobacter pylori negative were enrolled. PubMed, Embase, CNKI (Chinese national knowledge internet) were carefully searched and reviewed. Odds ratio (OR) together with 95% confidence interval (CI) were applied to calculate the association power. Results GG genotype of TLR4 gene rs4986790 polymorphism contributes increased risk to the population of Zhejiang, China ( p = 0.019). Meta‐analysis found that the positive findings came from Asian population by allele contrast ( p = 0.006), homozygote comparison ( p = 0.006) and recessive genetic model ( p = 0.001). Conclusion TLR4 gene rs4986790 polymorphism is associated with Helicobacter pylori infection risk for population of Zhejiang, China. Combined with individual gene polymorphism, the accuracy of risk assessment of Helicobacter pylori infection can be improved and individualized health education can be provided for patients with Helicobacter pylori infection by nurses.

Research Article Association between host genetic polymorphisms and susceptibility to <i>Helicobacter</i> <i>pylori</i> infection: a systematic review protocol

“…Genetic variability, which comprises genetic polymorphisms, is responsible for generating variations in morphology and physiology between individuals belonging to the same species. These factors play an extremely important role in regulating disease severity, especially when they are associated with the host's genetic components (Kalsoom et al, 2020;He and Jiang, 2022). An interaction between two polymorphisms can lead to a synergistic effect, resulting in a phenotypic alteration that increases cytokine production at the cellular level.…”