Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study

Chen, Mao; Yuan, Jingya; Lv, Yue; Gao, Xiang; Yin, Zhaoxue; Kraus, Virginia B.; Luo, Jie; Chei, Choy Lye; Matchar, David B.; Zeng, Yi; Shi, Xiao Ming

doi:10.1186/s12877-019-1109-z

Cited by 61 publications

(45 citation statements)

References 38 publications

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“…In the present study, low baseline serum levels of TAS, SOD, and high MDA could accelerate the progression of PACG. Limited data are available in the literature regarding the association of oxidative stress markers with PACG progression, but there has been increasing evidence showing that TAS, SOD, and MDA levels could serve as biomarkers to predict the progression or survival of different types of other diseases [ 33 – 36 ]. For example, Chen et al [ 33 ] performed a community-based cohort study of 2224 participants reporting that increased activity of SOD was independently associated with lower all-cause mortality in older women.…”

Section: Discussionmentioning

confidence: 99%

“…Limited data are available in the literature regarding the association of oxidative stress markers with PACG progression, but there has been increasing evidence showing that TAS, SOD, and MDA levels could serve as biomarkers to predict the progression or survival of different types of other diseases [ 33 – 36 ]. For example, Chen et al [ 33 ] performed a community-based cohort study of 2224 participants reporting that increased activity of SOD was independently associated with lower all-cause mortality in older women. A meta-analysis of five prospective studies showed that a significant inverse association was found between dietary TAS and all-cause mortality (combined effect size = 0.62, 95%CI = 0.60–0.64), cancer (combined effect size = 0.81, 95%CI = 0.75–0.88), and cardiovascular disease mortality (combined effect size = 0.71, 95%CI = 0.63–0.82) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

Shao

et al. 2020

Oxidative Medicine and Cellular Longevity

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Purpose. To investigate the serum changes of oxidative stress markers and the relationship between these factors and visual field (VF) progression in patients with primary angle closure glaucoma (PACG). Methods. A case-control and a prospective cohort study. A total of 94 patients with PACG and 89 normal controls were enrolled. Furthermore, 94 PACG subjects were followed up for at least two years (once every six months). All participants were evaluated for serum levels of superoxide dismutase (SOD), total antioxidant status (TAS), hydrogen peroxide (H2O2), malondialdehyde (MDA), glutathione peroxidase, glutathione reductase, and detailed eye and systematic examination. Binary logistic regression analysis and Cox regression analysis were performed. Results. The serum levels of SOD and TAS in the PACG group were significantly lower than those in the control group (p<0.001). Meanwhile, PACG subjects had significantly higher levels of MDA and H2O2 than the normal control subjects (p<0.001). Serum levels of TAS (OR=0.773, 95%CI=0.349−0.714, p<0.001), SOD (OR=0.975, 95%CI=0.955−0.995, p<0.001), MDA (OR=1.155, 95%CI=1.080−1.235, p<0.001), and H2O2 (OR=1.216, 95%CI=1.142−1.295, p<0.001) were independent risk/protective factors for PACG. TAS levels (HR=0.041, 95%CI=0.008–0.218, p<0.001), SOD levels (HR=0.983, 95%CI=0.971–0.994, p=0.003), and MDA levels (HR=1.010, 95%CI=1.001–1.018, p=0.015) at baseline were associated with visual field progression. Kaplan–Meier curves reveal that patients with TAS<0.95/SOD<143/MDA>12 had a significantly higher percentage of PACG progression (p<0.05). Conclusions. Decreased levels of TAS and SOD as well as increased levels of MDA at baseline were associated with VF progression in patients with PACG. These findings suggest that oxidative stress was involved in the onset and development of PACG.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

Shao

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Finally, it has been recently demonstrated that SOD activity is higher in women than in men [81], which could help explain why men tend to be more common victims of Winiwarter-Buerger disease [4,47,66].…”

Section: Discussionmentioning

confidence: 99%

The Imbalance among Oxidative Biomarkers and Antioxidant Defense Systems in Thromboangiitis Obliterans (Winiwarter-Buerger Disease)

Sharebiani

Fazeli

Maniscalco

et al. 2020

JCM

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(1) Background: Thromboangiitis obliterans or Winiwarter-Buerger disease (WBD), is an inflammatory, thrombotic occlusive, peripheral vascular disease, usually occurring in young smokers. The pathophysiological mechanisms underlying the disease are not clearly understood. The aim of this study is to investigate the imbalance between oxidants and antioxidants occurring in these patients. (2) Patients and Methods: In this cross-sectional study, 22 male patients with WBD and 20 healthy male smoking habit matched control group were included. To evaluate the possible sources of oxidative stress, the antioxidant biomarkers, and the markers of lipid peroxidation and protein oxidation, serum samples were analyzed for total oxidative status (TOS), total antioxidant capacity (TAC), myeloperoxidase (MPO), coenzyme Q10 (CoQ10), superoxide dismutase (SOD), glutathione reductase (GR), malondialdehyde (MDA), and protein carbonyl (PC) activity and/or content. (3) Results: The circulating levels of TOS, TAC, and CoQ10 were significantly higher in WBD patients, with respect to healthy smokers as controls. No significant difference was found among the serum level of PC, total cholesterol, MPO, and GR activity in WBD patients and healthy smoker controls. The activity of SOD and the mean serum level of MDA were significantly lower in WBD patients, with respect to healthy smoker controls. (4) Conclusion: Considerably high levels of oxidative stress were detected in WBD patients, which were greater than the antioxidant capacity. The low level of MDA may be associated with the enzymatic degradation of lipid peroxidation products. High levels of CoQ10 and low levels of SOD may be related to a harmful oxidative cooperation, leading to the vasoconstriction of WBD, representing a promising tool to discern possible different clinical risks of this poorly understood peripheral occlusive disease.

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“…Antioxidant enzymes, such as glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT), serve as a primary defense system against oxidative stress [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Although these scavenger enzymes at first are inactivated when counteracting ROS, their expression is induced by the presence of reactive species [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Leukocyte Activation and Antioxidative Defense Are Interrelated and Moderately Modified by n-3 Polyunsaturated Fatty Acid-Enriched Eggs Consumption—Double-Blind Controlled Randomized Clinical Study

et al. 2020

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This placebo-controlled, double-blind, randomized, interventional study investigated the effects of low/intermediate doses of n-3 polyunsaturated fatty acids (PUFAs) on the endothelial function, markers of leukocyte activation, and oxidative status following dietary intake of n-3 PUFA-enriched hen eggs in young healthy individuals. Twenty young healthy adults of both sexes who consumed n-3 PUFA-enriched hen eggs (two eggs per day, for three weeks, total of approximately 407 mg/day n-3 PUFAs) or regular eggs (two eggs per day for three weeks, total of approximately 75 mg/day n-3 PUFAs) participated in this study. Skin microvascular endothelium-independent and endothelium-dependent vasodilation were assessed by laser Doppler flowmetry. Serum lipid profile and content of free fatty acids, markers of leukocyte activation, biochemical parameters of oxidative stress, as well as antioxidative enzymes serum activity were measured before and after respective dietary protocol. The results of this study revealed significant differences in the markers of leukocyte activation (such as CD11a/LFA-1) and antioxidative defense, which are related to increased intake of n-3 PUFAs, providing the evidence that consumption of nutritionally enriched hen eggs may affect physiological processes related to oxidative balance. The absence of significant changes in microvascular reactivity following supplementation with a low-intermediate dose of n-3 PUFAs, unlike in our previous studies where functional eggs contained ~1 g of n-3 PUFA, suggests the existence of a dose-dependent effect.

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Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study

Cited by 61 publications

References 38 publications

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

The Imbalance among Oxidative Biomarkers and Antioxidant Defense Systems in Thromboangiitis Obliterans (Winiwarter-Buerger Disease)

Leukocyte Activation and Antioxidative Defense Are Interrelated and Moderately Modified by n-3 Polyunsaturated Fatty Acid-Enriched Eggs Consumption—Double-Blind Controlled Randomized Clinical Study

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