“…In aqueous humor levels of IL-1β [ 175 , 197 ], IL-8, IP-10 [ 174 ], IL-6 [ 175 , 176 , 177 , 197 ], TNF-α [ 187 , 208 , 209 ], MCP-1 [ 174 ] (24), IL-2, IL-5 [ 175 ], and VEGF [ 169 , 174 , 176 , 177 , 178 ] were higher in patients with certain type of DR compared to controls. Most of the proteins reported in aqueous are correlated with vitreous: IL-6 [ 177 , 179 , 180 , 181 ], VEGF [ 182 , 183 , 184 , 185 ], IL-8 [ 184 , 192 , 194 ], IP-10 [ 186 ], MIP-1β, TNF-α [ 180 ], MCP-1 [ 184 , 192 , 210 ], PlGF [ 180 ], and VEGF. The vitreous and aqueous levels of IL-6 and VEGF were significantly correlated with the severity of diabetic retinopathy and with the pathogenesis of diabetic macular edema [ 183 , 189 , 211 ].…”