2021
DOI: 10.3390/pharmaceutics13091376
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From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

Abstract: Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration and diabetic retinopathy, have their origin in the posterior segment of the eye, making their physiopathology both complex and interconnected. In addition to the age factor, these diseases share the same mechanism disorder based essentially on oxidative stress. In this context, the imbalance between the production of reactive oxygen species (ROS) mainly by mitochondria and their eli… Show more

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Cited by 40 publications
(33 citation statements)
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“…In fact, neutrophils, macrophages, mast cells and activated microglia can produce and release a variety of factors that promote new vessel formation, in particular VEGF. The final effect of this cascade is the death of photoreceptors due to disturbances in the nutrient supply, retention of morphotic elements extravasated through the walls of abnormal vessels, and scarring [ 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…In fact, neutrophils, macrophages, mast cells and activated microglia can produce and release a variety of factors that promote new vessel formation, in particular VEGF. The final effect of this cascade is the death of photoreceptors due to disturbances in the nutrient supply, retention of morphotic elements extravasated through the walls of abnormal vessels, and scarring [ 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, oxidative stress has been suggested as a critical factor in the pathogenesis of various retinal degenerative diseases ( Chan et al, 2020 ; Dammak et al, 2021 ; Clementi et al, 2022 ). Therefore, the application of antioxidants to preserve RPE functional integrity from oxidative damage can be considered as one of the prospective approaches to reduce the pathogenesis of ocular diseases including retinal degeneration ( Léveillard et al, 2019 ; Sadda et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…Серед них основними вважаються дві теорії, що найчастіше використовуються для пояснення патогенезу глаукоми -механічна та судинна, і в обох ключова роль відведена окислювальному стресу [14]. Крім того, генетичні аномалії ініціюють каскад подій, що призводять до глаукоматозного пошкодження та ремоделювання зорового нерва [22].…”
Section: результати та їх обговоренняunclassified