The Imbalance among Oxidative Biomarkers and Antioxidant Defense Systems in Thromboangiitis Obliterans (Winiwarter-Buerger Disease)

Sharebiani, Hiva; Fazeli, Bahare; Maniscalco, Rosanna; Ligi, Daniela; Mannello, Ferdinando

doi:10.3390/jcm9041036

Cited by 21 publications

(14 citation statements)

References 78 publications

(116 reference statements)

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“…Oxidative damage includes lipid peroxidation and oxidative DNA damage. MDA is the stable metabolite of lipid peroxidation and has been extensively measured as an indicator for oxidative damage ( Sharebiani et al, 2020 ). 8-OHdG is known to be a sensitive biomarker of oxidative DNA damage in urine and leukocytes ( Liu et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease

et al. 2021

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Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure, but therapeutic options for nephroprotection are limited. Oxidative stress plays a key role in the pathogenesis of DKD. Our previous studies demonstrated that tetramethylpyrazine nitrone (TBN), a novel nitrone derivative of tetramethylpyrazine with potent free radical-scavenging activity, exerted multifunctional neuroprotection in neurological diseases. However, the effect of TBN on DKD and its underlying mechanisms of action are not yet clear. Herein, we performed streptozotocin-induced rat models of DKD and found that TBN administrated orally twice daily for 6 weeks significantly lowered urinary albumin, N-acetyl-β-D-glycosaminidase, cystatin C, malonaldehyde, and 8-hydroxy-2′-deoxyguanosine levels. TBN also ameliorated renal histopathological changes. More importantly, in a nonhuman primate model of spontaneous stage III DKD, TBN increased the estimated glomerular filtration rate, decreased serum 3-nitrotyrosine, malonaldehyde and 8-hydroxy-2′-deoxyguanosine levels, and improved metabolic abnormalities. In HK-2 cells, TBN increased glycolytic and mitochondrial functions. The protective mechanism of TBN might involve the activation of AMPK/PGC-1α-mediated downstream signaling pathways, thereby improving mitochondrial function and reducing oxidative stress in the kidneys of DKD rodent models. These results support the clinical development of TBN for the treatment of DKD.

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Section: Resultsmentioning

confidence: 99%

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease

et al. 2021

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“…No significant difference between PC, GR, and MPO levels has been demonstrated in TAO vs. controls [35]. However, a higher level of PC has been reported in both atherosclerosis and SLE [49,50].…”

Section: Oxidative Stressmentioning

confidence: 91%

“…Recently, a significantly lower level of MDA and SOD has been reported in TAO patients compared to smoker controls [35]. Notably, a higher level of MDA and SOD has been reported in atherosclerosis [33].…”

Section: Oxidative Stressmentioning

confidence: 97%

“…A low serum level of NO metabolites in TAO has been reported compared to smoking controls, which might be one reason for high oxidative stress in TAO. Nevertheless, it is not well defined if the low NO level is responsible for high oxidative stress in TAO or secondary to high oxidative stress [35]. Moreover, it has been reported that polymorphisms in the promoter region of nitric oxide synthase correlate with major amputation in TAO patients [36].…”

Section: Oxidative Stressmentioning

confidence: 99%

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Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences

et al. 2021

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Thromboangiitis obliterans (TAO) or Buerger’s disease is a segmental inflammatory, thrombotic occlusive peripheral vascular disease with unknown aetiology that usually involves the medium and small-sized vessels of young male smokers. Due to its unknown aetiology and similarities with atherosclerosis and vasculitis, TAO diagnosis is still challenging. We aimed to review the status of biomolecular and laboratory para-clinical markers in TAO compared to atherosclerosis and vasculitis. We reported that, although some biomarkers might be common in TAO, atherosclerosis, and vasculitis, each disease occurs through a different pathway and, to our knowledge, there is no specific and definitive marker for differentiating TAO from atherosclerosis or vasculitis. Our review highlighted that pro-inflammatory and cell-mediated immunity cytokines, IL-33, HMGB1, neopterin, MMPs, ICAM1, complement components, fibrinogen, oxidative stress, NO levels, eNOS polymorphism, adrenalin and noradrenalin, lead, cadmium, and homocysteine are common markers. Nitric oxide, MPV, TLRs, MDA, ox-LDL, sST2, antioxidant system, autoantibodies, and type of infection are differential markers, whereas platelet and leukocyte count, haemoglobin, lipid profile, CRP, ESR, FBS, creatinine, d-dimer, hypercoagulation activity, as well as protein C and S are controversial markers. Finally, our study proposed diagnostic panels for laboratory differential diagnosis to be considered at first and in more advanced stages.

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“…Notably, thrombogenicity and high oxidative stress, independent from smoking, has been demonstrated in BD patients [19,20]. Interestingly, semen contains clotting and brinolysis factors which have a signi cant role in male reproductive physiology including the motility and function of sperms [21].…”

Section: Conditionmentioning

confidence: 99%

Secondary Infertility: A Neglected Aspect of Buerger’s Disease

Ziaeemehr

Sharebiani

Taheri

et al. 2020

Preprint

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Aim: During the gathering of demographic data for the biobank on Buerger’s Disease (BD), we found that, after the clinical manifestation of BD, the patients usually became infertile, and the age of their last child was compatible with the time of disease diagnosis. The aim of this study was to evaluate the underlying cause of secondary infertility in BD patients.Method: Anti-sperm antibodies (ASA), testosterone, luteinising hormone (LH), and follicle-stimulating hormone (FSH) in the sera of 39 male BD patients were measured and compared with 39 age-matched Caucasian male controls.Results: Six patients declared that they suffered from impotency. The ASA level was positive in 25.6% of the patients and 2.4% of the controls (p = 0.003, CC = 6.96). The mean levels of testosterone in the patients and controls were 393.12 ± 32.9ng/dl and 354.37 ± 30.9ng/dl, respectively. The mean levels of LH in the patients and controls were 0.88 ± 0.12mIU/r and 0.85 ± 0.1mIU/r, respectively. The mean levels of FSH in the patients and controls were 4.1 ± 0.35mIU/r and 3.56 ± 0.33mIU/r, respectively. No significant difference in the serum levels of testosterone, LH, or FSH was found between the patients and controls (p > 0.05). The spermograms of three ASA-negative patients demonstrated impaired sperm motility.Conclusion: Anti-sperm antibodies, disturbed genital circulation, autonomic dysfunction and sperm motility may be responsible for secondary infertility in Buerger’s Disease. Ethical code: MUMS-941842

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The Imbalance among Oxidative Biomarkers and Antioxidant Defense Systems in Thromboangiitis Obliterans (Winiwarter-Buerger Disease)

Cited by 21 publications

References 78 publications

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease

Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences

Secondary Infertility: A Neglected Aspect of Buerger’s Disease

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