Associations between source-indicative pollution metrics and increases in pulmonary inflammation and reduced lung function in a panel of asthmatic children

Greenwald, Roby; Sarnat, Stefanie Ebelt; Raysoni, Amit U.; Li, Wen Whai; Johnson, Brent A.; Stock, Thomas H.; Holguín, Fernando; Sosa, Teresa; Sarnat, Jeremy A.

doi:10.1007/s11869-012-0186-3

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…VOC sources in the classroom come from household products use including solvent, adhesive, paint, cleaning product, furniture and air freshener (Shook-Sa, Chen, & Zhou, 2017). This is similar to research conducted in Texas that VOC concentrations came from cleaning agents, furniture polish, materials used in arts and crafts activities, use of hot water, and deodorizing cakes used in urinal pots were the main sources for indoor concentration high (Greenwald et al, 2013;Raysoni et al, 2017).…”

Section: Discussionsupporting

confidence: 60%

Indoor Air Pollution (Carbon Dioxide and Total Volatile Organic Compound) and Pulmonary Disorders in Junior High School Students in Depok, West Java

Wispriyono¹,

Yulaeva²,

Hartono³

et al. 2019

GJHS

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Good indoor air quality in the school environment is crucial for health and productivity of the students. Indoor air pollution needs to be taken into consideration, given that one can spend 90% of their time indoor. CO2 and Total VOC is an indoor pollutant that causes pulmonary disorder. This research is to investigate the relationship between exposure of CO2, concentration, total VOC and pulmonary disorder in Junior High School students. This research used cross-sectional design conducted on March - May 2018. The samples were 139 students taken by using simple random sampling. CO2 value was measured by Q-trak, Total VOC was measured by ppbRAE and the lung function value was spirometry. Indoor CO2 concentration in Junior High School of  Depok is 478.70 ppm, the average total concentration VOC is 6.4 x 10-3 ppm, % KVP = 72.66, % VEP1 = 74.52 and % VEP1/KVP = 93.97 in average, and the proportion of students with pulmonary disorder is 3.6%. There is no relationship found between exposure of indoor CO2 concentration and total VOC with lung disorder VEP1/KVP (CO2, p = 1.000 and total VOC p = 0.374) since the number of students with lung disorder is low in number while CO2 concentration and the total VOC level is below the listed threshold. This study found no evidence that exposure was related to pulmonary disorder. A healthy and clean living behavior in school environment needs to be improved and further research on other indoor air pollutant parameters and respiratory disorders or degenerative disease should be conducted with different methods.

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Section: Discussionsupporting

confidence: 60%

Indoor Air Pollution (Carbon Dioxide and Total Volatile Organic Compound) and Pulmonary Disorders in Junior High School Students in Depok, West Java

Wispriyono¹,

Yulaeva²,

Hartono³

et al. 2019

GJHS

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“…Sarnat and colleagues [ 17 ] measured FENO in a panel of school children for 16 weeks and found that particle matter from traffic and other sources, rather than NO 2 , was associated with FENO. Greenwald and colleagues [ 35 ] measured FENO in a panel of elementary school students were measured weekly for 13 weeks to estimate the effects of exposure to diesel truck traffic, but no association was found in healthy children. Koenig and colleagues [ 36 ] measured children for 10 days while monitoring indoor and outdoor PM 2.5.…”

Section: Discussionmentioning

confidence: 99%

“…As the few asthmatic children in the recruited population were all treated with anti-inflammatory medication that may attenuate FENO response [ 35 ], these children were excluded from the study population. Some children with rhinitis were, however, included, and we lack the information about the daily use of nasal steroids, but this seems unlikely to confound the results as we studied the effects of short-term fluctuations in air pollution.The lack of information about daily use of medication against rhinitis is not likely to be a confounding problem as we study short-term effects of fluctuations in air pollution.…”

Section: Discussionmentioning

confidence: 99%

Coarse Fraction Particle Matter and Exhaled Nitric Oxide in Non-Asthmatic Children

Carlsen

Boman

Björ

et al. 2016

IJERPH

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Coarse particle matter, PMcoarse, is associated with increased respiratory morbidity and mortality. The aim of this study was to investigate the association between short-term changes in PMcoarse and sub-clininal airway inflammation in children. Healthy children aged 11 years from two northern Swedish elementary schools underwent fraction of exhaled nitrogen oxide (FENO) measurements to determine levels of airway inflammation twice weekly during the study period from 11 April–6 June 2011. Daily exposure to PMcoarse, PM2.5, NO2, NOx, NO and O3 and birch pollen was estimated. Multiple linear regression was used. Personal covariates were included as fixed effects and subjects were included as a random effect. In total, 95 children participated in the study, and in all 493 FENO measurements were made. The mean level of PMcoarse was 16.1 μg/m3 (range 4.1–42.3), and that of O3 was 75.0 μg/m3 (range: 51.3–106.3). That of NO2 was 17.0 μg/m3 (range: 4.7–31.3), NOx was 82.1 μg/m3 (range: 13.3–165.3), and NO was 65 μg/m3 (range: 8.7–138.4) during the study period. In multi-pollutant models an interquartile range increase in 24 h PMcoarse was associated with increases in FENO by between 6.9 ppb (95% confidence interval 0.0–14) and 7.3 ppb (95% confidence interval 0.4–14.9). PMcoarse was associated with an increase in FENO, indicating sub-clinical airway inflammation in healthy children.

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“…Given the relatively short follow-up period for this study, however, inferences relating to the temporality of any of the endpoints should be viewed cautiously. Numerous studies have reported associations between air pollution and acute eNO response utilizing panel based designs (Adamkiewicz et al, 2004; Buonanno et al, 2013; Delfino et al, 2006; Greenwald et al, 2013; Sarnat et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters

Sarnat

Golan

Greenwald

et al. 2014

Environmental Research

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Background Exposure to traffic pollution has been linked to numerous adverse health endpoints. Despite this, limited data examining traffic exposures during realistic commutes and acute response exists. Objectives: We conducted the Atlanta Commuters Exposures (ACE-1) Study, an extensive panel-based exposure and health study, to measure chemically-resolved in-vehicle exposures and corresponding changes in acute oxidative stress, lipid peroxidation, pulmonary and systemic inflammation and autonomic response. Methods We recruited 42 adults (21 with and 21 without asthma) to conduct two 2-h scripted highway commutes during morning rush hour in the metropolitan Atlanta area. A suite of in-vehicle particulate components were measured in the subjects’ private vehicles. Biomarker measurements were conducted before, during, and immediately after the commutes and in 3 hourly intervals after commutes. Results At measurement time points within 3 h after the commute, we observed mild to pronounced elevations relative to baseline in exhaled nitric oxide, C-reactive-protein, and exhaled malondialdehyde, indicative of pulmonary and systemic inflammation and oxidative stress initiation, as well as decreases relative to baseline levels in the time-domain heart-rate variability parameters, SDNN and rMSSD, indicative of autonomic dysfunction. We did not observe any detectable changes in lung function measurements (FEV1, FVC), the frequency-domain heart-rate variability parameter or other systemic biomarkers of vascular injury. Water soluble organic carbon was associated with changes in eNO at all post-commute time-points (p < 0.0001). Conclusions Our results point to measureable changes in pulmonary and autonomic biomarkers following a scripted 2-h highway commute.

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Associations between source-indicative pollution metrics and increases in pulmonary inflammation and reduced lung function in a panel of asthmatic children

Cited by 13 publications

References 34 publications

Indoor Air Pollution (Carbon Dioxide and Total Volatile Organic Compound) and Pulmonary Disorders in Junior High School Students in Depok, West Java

Indoor Air Pollution (Carbon Dioxide and Total Volatile Organic Compound) and Pulmonary Disorders in Junior High School Students in Depok, West Java

Coarse Fraction Particle Matter and Exhaled Nitric Oxide in Non-Asthmatic Children

Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters

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