Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China

Lu, Shaoyou; Li, Yanxi; Zhang, Jianqing; Zhang, Tao; Liu, Guihua; Huang, Mingzhi; Xiao, Li; Ruan, Jujun; Kannan, Kurunthachalam; Qiu, Rongliang

doi:10.1016/j.envint.2016.05.021

Cited by 121 publications

(49 citation statements)

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“…Consistently, PM metal chelation prevents the systemic inflammatory response induced in mice by repeated PM intratracheal instillations [ 72 ]. Quinones [ 73 ] and polycyclic aromatic hydrocarbons [ 74 ] present in PM are likely to also contribute to the oxidative potential of cPM D . The increase in serum MDA concentrations that we observed in cPM D -exposed mice reflects systemic oxidative stress, which is a well-known effect of PM in rats [ 75 ] and in humans [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

et al. 2017

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BackgroundAir pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation.ResultsThe collected PM had classical features of urban particles and possessed oxidative potential partly attributable to their metal fraction. Bioaccessibility study confirmed the high solubility of some metals at the gastric level. Male mice were exposed to urban coarse PM in a ventilated inhalation chamber for 15 days at a concentration relevant to episodic elevation peak of air pollution. Coarse PM inhalation induced systemic oxidative stress, recruited immune cells to the lung, and increased cytokine levels in the lung and colon. Concomitant oral administration of NAC reversed all the observed effects relative to the inhalation of coarse PM.ConclusionsCoarse PM-induced low-grade inflammation in the lung and colon is mediated by oxidative stress and deserves more investigation as potentiating factor for inflammatory diseases.Electronic supplementary materialThe online version of this article (10.1186/s12989-017-0227-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

et al. 2017

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“…Similar levels were also reported by Wang et al [120] who found higher PAH concentration in e-waste burning site than the adjacent agricultural area, reporting that PAH levels are different and chest circumference had a negative correlation with PAH levels in blood. Insight on human exposure to PAH were also obtained by Lu et al [122], who measured PAH levels in urine of occupationally and non-occupationally exposed receptors. Results showed significant difference between the exposed and reference group as well as between workers (occupationally exposed) and residents (non-occupationally exposed) in the e-recycling area.…”

Section: Soilmentioning

confidence: 94%

“…[111,112].  Evidence of PAHs in children's blood [122], adult urine [123], and hair [124]  Evidence in soils and dusts provided by several authors, all of whom detected levels exceeding USEPA soil screening levels five to thirty times [52,64,67,107] with one exception where levels were lower than the open burning sites elsewhere [107].  Non-carcinogenic risk determined by one author [67] who scored it low in all but one example in this source pathway reception context.…”

Section: Risk Characterisation Of Substances Emitted From Open Burninmentioning

confidence: 99%

Thermal deconstruction, open burning and disposal of e-waste without pollution control: A systematic review of risks to occupational and public health

Cook¹,

Velis²,

Gerassimidou³

et al. 2020

Preprint

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The critical functionality provided by the informal e-waste recycling sector to the global circular economy is marred by the hazardous emissions from this practice when it is carried out under informal and unregulated conditions in the Global South. Here, we focus a systematic review (PRISMA) of evidence specifically on rudimentary thermal processing activities that are carried out to disassemble and recover metals bonded into the complex assemblies and composites of electrical and electronic products and items. We identified main combinations of hazard-pathway-receptor (H-P-R) associated with exposure to risk and ranked them to indicate severity and prioritise research needs and interventions. Two practices, open burning and heating/melting/roasting are highly efficient in comparison to mechanical disassembly of many components and materials, presenting a challenge for actors who want to discourage them. Yet, these activities result in significant and very serious potential health effects as evidenced by 48 references screened and critically assessed. Though a large body of research exists that report observations of potentially hazardous substances in environmental media and human bodies, there is an abject paucity of reliable or even indicative data to indicate the scale of the e-waste processing activity. Moreover, the concentrations measured in almost all studies suffer from a multiplicity of confounding activities, creating challenges regarding identifying the activity source. System level interventions should be designed to effectively mitigate the risk, whilst rapidly transitioning to low-risk processing with effective pollution abatement in place and safe systems of work.

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“…Тиоредоксиновая система участвует в репарации белков и не напрямую -через восстановление метионин-сульфоксид редуктаз, отвечающих за восстановление окисленного метионина. А также тиоредоксиновая АОС восстанавливает рибонуклеотидредуктазы -ферменты, имеющие ключевое значение для синтеза ДНК [30] и обеспечивает защиту структуры ДНК за счет поддержания редокс-потенциала клеток, передачи сигнала остальным участникам антиоксидантной защиты, участвуя в репарации возникших повреждений молекулы ДНК [21]. самым ингибируя ее активность.…”

Section: рис 2 функциональная роль тиоредоксина в клеткеunclassified

“…Рассмотренные выше литературные данные показали, что активность тиоредоксиновой и глутатионовой АОС направлена на поддержание физиологического уровня окислительно-восстановительного баланса и репарацию клеточных макромолекул, и, по мнению J.Lu, A.Holmgren [30], эти системы работают согласованно и способны к взаимному «подстраховыванию» (рис. 3).…”

Section: рис 2 функциональная роль тиоредоксина в клеткеunclassified

Regulation by thiol disulfide and antioxidant systems of oxidative stress induced by atmospheric suspended particles

Barskova

Виткина

2019

Bûlletenʹ fiziologii i patologii dyhaniâ

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Владивостокский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания»-Научно-исследовательский институт медицинской климатологии и восстановительного лечения, 690105, г. Владивосток, ул. Русская 73г Контактная информация Людмила Сергеевна Барскова, аспирант, младший научный сотрудник, лаборатория медицинской экологии и рекреационных ресурсов, Владивостокский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания»-Научно-исследовательский институт медицинской климатологии и восстановительного лечения, 690105, Россия, г. Владивосток, ул. Русская, 73г.

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Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China

Cited by 121 publications

References 50 publications

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

Thermal deconstruction, open burning and disposal of e-waste without pollution control: A systematic review of risks to occupational and public health

Regulation by thiol disulfide and antioxidant systems of oxidative stress induced by atmospheric suspended particles

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