Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales

Simond, Antoine E.; Houde, Magali; Lesage, Véronique; Michaud, Robert; Zbinden, Dany; Verreault, Jonathan

doi:10.1016/j.marpolbul.2019.05.029

Cited by 31 publications

(16 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hexabromobenzene levels in blubber in the 8 killer whales ( Orcinus orca ) from the present study (2015–2017) compared to minke whales (2015–2017, n = 11) and beluga whales (2015–2017, n = 45) from the St Lawrence estuary, Canada (Simond et al 2019); polar bears from West Hudson Bay, Canada (2003, n = 12; Mckinney et al 2010); and right whales from the northwest Atlantic Ocean (1997–2006, n = 5; Montie et al 2010). The dot represents the median value, except for the beluga and minke whales, where the dot is the mean.…”

Section: Resultsmentioning

confidence: 64%

“…The toxicity of emerging BFRs has been little studied; however, associations have been found in cetaceans between HBB and the transcription of thyroid‐ and/or steroid‐related genes (Simond et al 2019). Levels of emerging BFRs in the present study are, however, several orders of magnitude lower than those of the legacy PBDEs, contributing just 0.4% of the total ΣBFR levels in the blubber and only 0.01% of the total Σorganochlorine + ΣBFR levels in the blubber (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017

Andvik

Jourdain²,

Lyche

et al. 2021

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Little is known of the movement or presence of unregulated, emerging contaminants in top predators. The aim of the present study was to conduct the first screening of legacy and emerging contaminants in multiple tissues of killer whales (Orcinus orca) from Norway and investigate tissue partitioning and maternal transfer. Blubber was collected from 8 killer whales in 2015 to 2017, in addition to muscle from 5 of the individuals, and kidney, liver, heart, and spleen from a neonate. We screened for 4 unregulated brominated flame retardants and found pentabromotoluene (PBT) and hexabromobenzene (HBB) at low levels in the blubber of all individuals (median PBT 0.091 ng/g lipid wt, median HBB 1.4 ng/g lipid wt). Levels of PBT and HBB (wet wt) were twice as high in the blubber than the muscle for each individual, confirming preferential accumulation in lipid-rich tissues. Perfluoroalkyl substances and total mercury levels were lower in the neonate than adults, suggesting less efficient maternal transfer of these substances. Polychlorinated biphenyl levels in blubber exceeded the threshold for onset of physiological effects (9 µg/g lipid wt) in 7 of the 8 whales, including the neonate. The presence of PBT and HBB in the neonate is the first evidence of maternal transfer of these unregulated contaminants in marine mammals. Our results are relevant for the continued environmental monitoring of contaminants in the Arctic. Environ Toxicol Chem 2021;00:1-11.

show abstract

Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 99%

High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017

Andvik

Jourdain²,

Lyche

et al. 2021

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Roles for regulation of these pathways via post-translational deimination have not been investigated. Thyroid hormones have been studied in a range of whales and dolphins, including for evaluation of energetics and stress Hunt et al, 2019), as well as environmental pollution (Buckmann et al, 2011;Villanger et al, 2011;Hunt et al, 2017;Simond et al, 2019). PADs have been related to thyroid cancer (Guo et al, 2017) and deimination of histone H3 has been linked to autoimmune thyroid disease (Morshed et al, 2019), while physiological effects of deimination on thyroid hormone synthesis remain to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca

Magnadóttir

Uysal-Onganer

Kraev

et al. 2020

Comparative Biochemistry and Physiology Part D: Genomics and Pr

View full text Add to dashboard Cite

show abstract

“…Medicinal plants are still a reliable 18% rats that were exposed to Organohalogen Contaminants [11]. Hepatocytic microvesicular lipid accumulation (foamy cytoplasm), sharply demarcated macrovesicular lipid vacuoles in mainly periacinar (zones 2-3) hepatocytes was also reported [12], source of active molecules (polyphenols, flavonoids) known for their antioxidant properties [13].…”

Section: Discussionmentioning

confidence: 99%

Effects of <i>Moringa oleifera</i> Biochemical Constituents on Kidney, Liver and Brain of Wister Rats

Hassan¹,

Saidu²,

Ishaq³

et al. 2020

SJAC

View full text Add to dashboard Cite

Medicinal plant have evolved over the centuries as essential parts of African civilization and are widely recognized today as representing its rich cultural and scientific heritage. The increasing demand for Medicinal plant products has renewed interest in the pharmaceutical industry in the production of herbal health care formulations, herbal-based cosmetic products, and herbal nutritional supplements. Thus, in addition to serving medical and cultural functions, Medicinal plants in Africa have economic importance. Global and national markets have been growing for medicinal herbs, and significant economic gains are being realized through the sale of medicinal plant products. The aim of this particular investigation was to observe the effects of Moringa oleifera 80% methanol leaf extract on the histological architecture of kidney, liver and brain tissues. Fifteen (15) rats were randomLy divided into three (3) with five rats per group. Rats were exposed to 2000 mg/kg, 1000 mg/kg and 500 mg/kg of Moringa oleifera extract per os (p.o) along with the control group that was placed on commercial diet. There was no observed mortality in all experimental rats but there is deleterious effect in brain, liver and kidney in those that were exposed to higher doses especially the 2000 mg/kg. It's therefore concluded that higher dose of Moringa oleifera is toxic while moderate doses is safe to most vital organs especially brain, liver and kidney. There is need for further investigation to identify the phytochemical constituents that are responsible for the toxic effects.

show abstract

Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales

Cited by 31 publications

References 67 publications

High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017

High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca

Effects of <i>Moringa oleifera</i> Biochemical Constituents on Kidney, Liver and Brain of Wister Rats

Contact Info

Product

Resources

About

Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales

Cited by 31 publications

References 67 publications

High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017

High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca

Effects of &lt;i&gt;Moringa oleifera&lt;/i&gt; Biochemical Constituents on Kidney, Liver and Brain of Wister Rats

Contact Info

Product

Resources

About

Effects of <i>Moringa oleifera</i> Biochemical Constituents on Kidney, Liver and Brain of Wister Rats