Effects of <i>Moringa oleifera</i> Biochemical Constituents on Kidney, Liver and Brain of Wister Rats

Abstract

Medicinal plant have evolved over the centuries as essential parts of African civilization and are widely recognized today as representing its rich cultural and scientific heritage. The increasing demand for Medicinal plant products has renewed interest in the pharmaceutical industry in the production of herbal health care formulations, herbal-based cosmetic products, and herbal nutritional supplements. Thus, in addition to serving medical and cultural functions, Medicinal plants in Africa have economic importance. Global and national markets have been growing for medicinal herbs, and significant economic gains are being realized through the sale of medicinal plant products. The aim of this particular investigation was to observe the effects of Moringa oleifera 80% methanol leaf extract on the histological architecture of kidney, liver and brain tissues. Fifteen (15) rats were randomLy divided into three (3) with five rats per group. Rats were exposed to 2000 mg/kg, 1000 mg/kg and 500 mg/kg of Moringa oleifera extract per os (p.o) along with the control group that was placed on commercial diet. There was no observed mortality in all experimental rats but there is deleterious effect in brain, liver and kidney in those that were exposed to higher doses especially the 2000 mg/kg. It's therefore concluded that higher dose of Moringa oleifera is toxic while moderate doses is safe to most vital organs especially brain, liver and kidney. There is need for further investigation to identify the phytochemical constituents that are responsible for the toxic effects.

Evaluating the Effects of <i<Moringa Oleifera</i> Leaf Extract on Testosterone Level of Male Wistar Rats Exposed to Petrol, Diesel and Kerosene

“…powerful antioxidant effect of Moringa oleifera, This study was aimed at determining changes in as reported by (Hassan et al, 2020). Moreover, testosterone levels of Wistar rats exposed to petrol, (Oa et al, 2017) illustrated that the presence of diesel and kerosene and the ameliorative effect of flavonoids in Moringa oleifera leaf extract has a Moringa oleifera leaf extract on the rats.…”

“…A lot of above the sea level (Nata, 2009). The state shares publications have reported some of the specific effects common borders with Niger Republic to the of Moringa oleifera leaf extract on some body tissues North, Kebbi State to the South and Zamfara or organs (Hassan et al, 2020). It has an impressive…”

Cerebroprotective effects of Moringa oleifera derivatives extracts against MCAO ischemic stroke: A systematic review and meta-analysis

“…MO is also a rich source of a wide range of phytochemicals, which, when purified, each have their own unique medicinal properties [ 13 ]. Whilst its phytochemistry is has been largely investigating for managing diseases like diabetes mellitus and hypertension [ 14 ], recent studies have suggested that MO's derivatives may act as promising neuroprotective agents against ischemic stroke but reducing the oxidative stress [ [15] , [16] , [17] , [18] ] ( Fig. 1 ).…”

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Fig. 1 Hypothesised effect of Moringa oleifera on the ischemic cascade [ [15] , [16] , [17] , [18] ]. Created witg BioRender.com.

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