Cerebroprotective effects of Moringa oleifera derivatives extracts against MCAO ischemic stroke: A systematic review and meta-analysis

Cuschieri, Andrea; Camilleri, Emma; Blundell, Renald

doi:10.1016/j.heliyon.2023.e16622

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…A systematic review and meta-analysis showed that saffron supplementation can significantly increase TAC and GSH-P X levels, suggesting that saffron may reduce oxidative stress markers [191]. The main mechanism of the neuroprotective effect of moringa extract and its phytochemical derivatives is to reduce oxidative stress by increasing antioxidant enzyme levels, reducing TAC levels, and inducing SOD and GSH overproduction [192]. In addition, a systematic review and meta-analysis showed that chromium supplementation significantly increases GSH levels [193].…”

Section: Related Adjunctive Therapies or Supplements Increase Antioxi...mentioning

confidence: 99%

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Chen,

Wang,

Chang

et al. 2024

IJMS

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Mitochondria are critical for providing energy to maintain cell viability. Oxidative phosphorylation involves the transfer of electrons from energy substrates to oxygen to produce adenosine triphosphate. Mitochondria also regulate cell proliferation, metastasis, and deterioration. The flow of electrons in the mitochondrial respiratory chain generates reactive oxygen species (ROS), which are harmful to cells at high levels. Oxidative stress caused by ROS accumulation has been associated with an increased risk of cancer, and cardiovascular and liver diseases. Glutathione (GSH) is an abundant cellular antioxidant that is primarily synthesized in the cytoplasm and delivered to the mitochondria. Mitochondrial glutathione (mGSH) metabolizes hydrogen peroxide within the mitochondria. A long-term imbalance in the ratio of mitochondrial ROS to mGSH can cause cell dysfunction, apoptosis, necroptosis, and ferroptosis, which may lead to disease. This study aimed to review the physiological functions, anabolism, variations in organ tissue accumulation, and delivery of GSH to the mitochondria and the relationships between mGSH levels, the GSH/GSH disulfide (GSSG) ratio, programmed cell death, and ferroptosis. We also discuss diseases caused by mGSH deficiency and related therapeutics.

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Section: Related Adjunctive Therapies or Supplements Increase Antioxi...mentioning

confidence: 99%

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Chen,

Wang,

Chang

et al. 2024

IJMS

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Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

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Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.

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Phytochemical Assessment and Potential Pharmacological Activity of Moringa Oleifera Extract

Turakhanova,

Bidzhieva,

Solovyeva

et al. 2024

Pharmacophore

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Cerebroprotective effects of Moringa oleifera derivatives extracts against MCAO ischemic stroke: A systematic review and meta-analysis

Cited by 3 publications

References 35 publications

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Phytochemical Assessment and Potential Pharmacological Activity of Moringa Oleifera Extract

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