Associations between Obesity, High Purine Consumptions, and Medications on Uric Acid Level with the Use of Allopurinol in Hyperuricemia Patients

Yunita, Ema Pristi; Fitriana, Dinar I.; Gunawan, Atma

doi:10.15416/ijcp.2018.7.1.1

Cited by 4 publications

(3 citation statements)

References 11 publications

(16 reference statements)

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“…Kadar asam urat dalam darah normalnya pada laki-laki 0,18-0,42 mmol/L (3,0-7,0 mg/dL) dan pada wanita kadarnya 0,13-0,34 mmol/L (2,2-5,7 mg/ dL) (Yunita et al, 2018).…”

Section: Pendahuluanunclassified

Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia

Arsa¹,

Putri

Nurwidyaningtyas

2021

JIKMH

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Abstrak Pendahuluan Hiperuresemia merupakan peningkatan kadar asam urat pada darah. Prevalensi hiperuresemia mengalami peningkatan. Gout merupakan gangguan metabolik yang ditandai dengan peningkatan kadar asam urat (hiperuresemia). Hiperuresemia jika tidak ditangani dengan tepat maka dapat dapat mengancam nyawa manusia. Tujuan dari penelitian ini adalah mengetahui gambaran kejadian hiperuresemia pada warga di RT 02 RW 03 Kelurahan Arjosari Kecamatan Blimbing Kota Malang. Data yang diteliti adalah jenis kelamin, usia, pendidikan, pekerjaan dan pendapatan. Metode penelitian yang digunakan design penelitian observasi analitik cross sectional, pengambilan data dilakukan dengan wawancara dan pengukuran kadar asam urat dalam darah melalui metode test stick kadar asam urat darah. Teknik pengambilan sampel menggunakan Simple Random Sampling dengan jumlah sampel 50 responden. Hasil penelitian didapatkan karakteristik responden berdasarkan jenis kelamin perempuan lebih besar 68,4 %, karakteristik usia sebagian besar berusia 50-59 tahun dengan persentase 42,1%, karakteristik responden berdasarkan pendidikan berasal jenjang perguruan tinggi sebesar 36,8 %, karakteristik responden berdasarkan jenis pekerjaan sebagian besar tidak bekerja/IRT sebesar 52,6% dan karakteristik responden berdasarkan pendapatan sebesar >2.000.000 perbulan dengan persentase 42,1 %. Kesimpulan Hasil penelitian ini diharapkan mampu dijadikan kebijakan kesehatan masyarakat untuk selalu menerapkan pola makan yang sehat, diet rendah purin, dan rutin berolahraga. Kata Kunci: Hiperuresemia; Asam urat; Karakteristik individu

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“…Kadar asam urat dalam darah normalnya pada laki-laki 0,18-0,42 mmol/L (3,0-7,0 mg/dL) dan pada wanita kadarnya 0,13-0,34 mmol/L (2,2-5,7 mg/ dL) (Yunita et al, 2018).…”

Section: Pendahuluanunclassified

Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia

Arsa¹,

Putri

Nurwidyaningtyas

2021

JIKMH

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“…Hyperuricemia is a disease that affects many Indonesian people. The two causes of hyperuricemia are decreased uric acid excretion in the distal tubule of the kidney's distal tubule and high uric acid levels in the body [1]. Uric acid that exceeds saturated levels in the body causes precipitation and crystallization.…”

Section: Introductionmentioning

confidence: 99%

Effect of kaffir lime (Cytrus hystrix) leaf extract on xanthine oxidase inhibition

Malikhah¹,

Herdyastuti²

2023

World J. Adv. Res. Rev.

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The xanthine oxidase enzyme is an enzyme that catalyzes purine metabolic reactions, the oxidation of hypoxanthine to uric acid through xanthine compounds. High uric acid causes hyperuricemia. One treatment is to inhibit the xanthine oxidase enzyme. It can be conducted with a natural remedy, for example kaffir lime leaf extract. Research showed that kaffir lime leaves contain flavonoids that can inhibit the activity of the xanthine oxidase. This research aimed to examine kaffir lime leaf extract as an inhibitor of xanthine oxidase enzyme activity. Isolation of kaffir lime leaves was conducted by various maceration times of 24, 48, and 72 hours. The method of determining the inhibition value (IC50) of kaffir lime leaf extract to the xanthine oxidase enzyme was UV-Vis spectrophotometer at λ 291,5 nm. Maceration results of kaffir lime leaf extract with phytochemical tests for 48 hours showed that there were phenolic, flavonoids, steroids, alkaloids, tannins, and triterpenoids compounds. FT-IR test showed that there were C=O, C=C aromatic, O-H, and CH-aliphatic groups, which indicated the structure of the flavonoids. Maceration of kaffir lime leaf extract for 48 hours was a weak inhibitor with an IC50 value of 285,82 ppm.

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“…Asam urat dapat disebabkan oleh dua faktor utama yaitu tingginya produksi kadar purin dalam tubuh akibat sintesis purin yang berlebihan dan penurunan ekskresi asam urat dalam tubulus distal ginjal (Yunita, Fitriana & Gunawan, 2018). Asam urat adalah senyawa sukar larut dalam air yang merupakan hasil akhir metabolisme purin (Ndede et al, 2019).…”

unclassified

Pemeriksaan Kadar Asam Urat Dan Konseling Di Kelurahan Bercak Wonosamudro Boyolali Jawa Tengah

Atmojo¹,

Putra²,

Mubarok³

et al. 2021

JurnalEmpathy

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Background: Uric acid is a disease that arises from excessive blood uric acid levels, which causes excessive blood uric acid levels, which is the production of more uric acid in the body from its disposal. There are several causes of gout, including changes in diet, consumption of drugs, and alcohol consumption. The purpose of implementing this community service activity is to provide education to the community in Bercak Village and to check uric acid levels. Methods: Based on the team's observations on several residents in Bercak Village, it was found that most residents did not have sufficient knowledge about gout and did not carry out routine health checks. In order to increase awareness and understanding of residents about health care efforts, especially preventing gout, the team coordinated with the urban village to carry out community service activities in Bercak Village, Wonosamudro, Boyolali. Results: The target in implementing this program is all residents in the Bercak Village, Wonosamudro, Boyolali. Community service activities were carried out on March 13, 2021, attended by the village head and also village officials and babinsa. Conclusion: After carrying out the activity, it is hoped that the community can follow up on the results of the examination and improve the behavior of efforts to prevent gout.

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Associations between Obesity, High Purine Consumptions, and Medications on Uric Acid Level with the Use of Allopurinol in Hyperuricemia Patients

Cited by 4 publications

References 11 publications

Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia

Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia

Effect of kaffir lime (Cytrus hystrix) leaf extract on xanthine oxidase inhibition

Pemeriksaan Kadar Asam Urat Dan Konseling Di Kelurahan Bercak Wonosamudro Boyolali Jawa Tengah

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