Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life

Tham, Elizabeth Huiwen; Phang, Kee Wei; Goh, Anne; Teoh, Oon Hoe; Chong, Yap Seng; Gluckman, Peter D.; Godfrey, Keith M.; Bever, Hugo Van; Lee, Bee Wah; Chong, Mary Foong‐Fong

doi:10.1111/pai.12995

Cited by 16 publications

(15 citation statements)

References 17 publications

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“…In contrast, the German LINA cohort study revealed that higher maternal Vitamin D levels were associated with an increased risk of food allergy and food sensitization in children at the age of 2 years [11]. In line with our findings, the Cork BASELINE birth cohort and the GUSTO study found that maternal Vitamin D levels were not associated with childhood food allergy food sensitization [15,32]. Similar findings were reported in an RCT conducted in the UK that failed to detect an effect of prenatal Vitamin D supplementation on the risk of food allergy in infants at 3 years of age [16].…”

Section: Discussionsupporting

confidence: 86%

“…Studies that assessed the associations between maternal Vitamin D levels and childhood food allergy and sensitization reported inconsistent results [10,11,15,32]. The Taiwan PATCH cohort study found that high maternal Vitamin D levels (≥75 nmol/L) were protective against food sensitization in children at age 1.5 and 2 years [10].…”

Section: Discussionmentioning

confidence: 99%

“…Similar findings were reported in an RCT conducted in the UK that failed to detect an effect of prenatal Vitamin D supplementation on the risk of food allergy in infants at 3 years of age [16]. It should be noted that the comparison of findings across studies might be difficult due to differences in terms of length of follow-up, the period of pregnancy at which maternal Vitamin D levels were measured, methods of food allergy and food sensitization measurement such as physician-diagnosed food allergy [11,15], skin prick test [15,32], or specific IgE-confirmed food sensitization [10]. In the present study, we did not observe an association between maternal Vitamin D levels and childhood food allergy, and we therefore speculate that other factors such as genetic factors may play a more important role in explaining this association.…”

Section: Discussionmentioning

confidence: 99%

“…There is lack of consistent findings addressing the associations between maternal Vitamin D levels and childhood eczema [14,15,32,34]. The inconsistent findings may be explained by the "U-shape" associations, suggesting that both lower and higher levels of Vitamin D are associated with a higher risk of eczema [14,34].…”

Section: Discussionmentioning

confidence: 99%

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Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study

et al. 2020

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Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels during late pregnancy and allergic diseases in Malaysian infants during the first year of life. Serum 25(OH)D concentrations of 380 pregnant women in the third trimester were measured using a chemiluminescent immunoassay. Children’s allergic outcomes were assessed at 3, 6, and 12 months based on parental reports. Specific IgE antibodies against food and inhalant allergens were measured in infants at 12 months of age. A total of 43.2% pregnant women were Vitamin D deficient (<30 nmol/L) and 56.8% were nondeficient (≥30 nmol/L). A total of 27.6% of the infants had eczema, 6.1% had wheeze, 27.4% had food sensitization, 10.8% had inhalant allergen sensitization, and 3.8% had IgE-mediated food allergy during the first year of life. Compared with the nondeficient group, maternal Vitamin D deficiency in late pregnancy was not associated with any allergic outcomes after adjustment for potential confounding factors. In conclusion, the present study does not support an association between maternal Vitamin D levels in late pregnancy and allergic outcomes during the first year of life.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study

et al. 2020

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“…However, follow-up of the same cohort showed an increased risk of eczema later in life ( 13 ). The immunomodulatory mechanism of vitamin D seems to have an influence on Th2 cells differentiation, but its benefits are still unclear and the literature is conflicting ( 14 ).…”

Section: Maternal Diet During Pregnancy: Does It Influence the Risk Omentioning

confidence: 99%

Current Insights on Early Life Nutrition and Prevention of Allergy

et al. 2020

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The incidence of allergic diseases in childhood appears to have significantly increased over the last decades. Since environmental factors, including diet, have been thought to play a significant role in the development of these diseases, there is great interest in identifying prevention strategies related to early nutritional interventions. Breastfeeding is critical for the immune development of newborns and infants through immune-modulating properties and it impacts the establishment of a healthy gut microbiota. However, the evidence for a protective role of breastfeeding against the development of food allergy in childhood is controversial, and there is little evidence to support the benefits of an antigen avoidance diet during lactation. Although it is not possible to draw a definitive conclusion about the protective role of breast milk against allergic diseases, exclusive breastfeeding is still recommended throughout the first 6 months of life due to associated health benefits. Furthermore, recommendations regarding complementary feeding in infancy have been significantly modified over the last few decades. Several studies have shown that delayed exposure to allergenic foods does not have a role in allergy prevention and recent guidelines recommend against delaying the introduction of complementary foods after 6 months of age, both in high-and low-risk infants. However, trials investigating this dietary approach have reported equivocal results so far. This review summarizes the available high-quality evidence regarding the efficacy of the principal dietary interventions proposed in early life to prevent allergic diseases in children.

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“You are my sunshine, my only sunshine”: maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes

Vasdeki,

Tsamos,

Koufakis

et al. 2023

Hormones

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Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life

Cited by 16 publications

References 17 publications

Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study

Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study

Current Insights on Early Life Nutrition and Prevention of Allergy

“You are my sunshine, my only sunshine”: maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes

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