Associations between maternal milk protein genotypes with preweaning calf growth traits in beef cattle

Hohmann, Lisa G; Weimann, Christina; Scheper, Carsten; Erhardt, G.; König, Sven

doi:10.1093/jas/skaa280

Cited by 4 publications

(4 citation statements)

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“…Braunschweig et al [30] compared the parental haplotypes B-B-A-A and B-B-A-B for CSN1S1-CSN2-CSN1S2-CSN3 in Swiss Brown Cattle and associated B-B-A-A with lower casein content and higher whey protein content in daughter milk. Similarly, the maternal composite casein genotype CSN1S1 BB -CSN2 A2A2 -CSN1S2 AA -CSN3 AB have been recently associated with pre-weaning offspring growth in German cattle [23].…”

Section: Introductionmentioning

confidence: 94%

“…Several investigations on cattle breeds in other countries associated milk protein variants with milk yield, composition and coagulation traits [20][21][22]. For instance, the β-CN A2 , predominant in zebu cattle presented positive effects on calf growth [23]. This variant is also of high interest for human health because of its ability to promote better digestion efficiency and antibacterial activity [14,17,24].…”

Section: Introductionmentioning

confidence: 99%

“…Gallinat et al [15] recently identified new milk protein variants, reflecting the evolutionary pattern in different cattle breeds. With regard to the variety of tools to assess genetic polymorphisms in milk protein genes and haplotypes (at protein or DNA level), genomic methods provide a wider overview of chromosome variations [14,23]. The latter approach is increasingly being used to characterize known and novel polymorphisms in cattle milk protein genes [9,14,47].…”

Section: Introductionmentioning

confidence: 99%

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First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants

Vanvanhossou

Giambra

Yin

et al. 2021

Genes

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This study investigated polymorphisms in the milk protein genes CSN1S1, CSN2, CSN1S2, CSN3, LALBA, and LGB, and casein haplotypes in Beninese indigenous cattle. Considering 67 animals, DNA sequencing of the genes’ exons, flanking regions and parts of the 5′-upstream regions identified 1058 genetic variants including 731 previously unknown. In addition, four novel milk protein variants were detected, including CSN3K (p.Ala66Val), LALBAF (p.Arg58Trp), LGBB1 (p.Ala134Val) and LGBK (p.Thr92Asnfs*13). CSN3K is caused by a novel SNP (BTA6:85656526C>T, exon 4) whereas LALBAF and LGBB1 are due to rs714688595C>T (exon 1) and rs109625649C>T (exon 4), respectively. Regarding LGBK, a frameshift insertion of one adenine residue at BTA11:103257980 (exon 3) induces a premature translation termination resulting in a 46% reduction of the reference protein sequence. The casein polymorphisms formed five main CSN1S1-CSN2-CSN1S2-CSN3 haplotypes including B-A1-A-B, B-A1-A-A and C-A2-A-B which are predominant in the investigated cattle breeds. Moreover, in silico analyses of polymorphisms within the 5′- and 3′- untranslated regions of all six milk proteins revealed effects on microRNA and transcription factor binding sites. This study suggests a large genetic variation of milk protein genes in Beninese cattle, which should be investigated in further studies for their effects on milk production, including quality and yield traits.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants

Vanvanhossou

Giambra

Yin

et al. 2021

Genes

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“…Barendse et al (2007) studies on the Angus breed revealed that the G/G genotype of the bRORC gene encoding the retinoic acid receptor has a positive effect on marbling. Hohmann et al (2020) studied the milk casein genes polymorphism in Angus breed females of the German population and determined the maternal casein genotypes influence on their calves' growth characteristics. It was found that calves from females with the K-CN BB and α s1-CN BB genotypes had higher indicators of average daily growth and live weight at weaning.…”

Section: Introductionmentioning

confidence: 99%

Marking of Meat Productivity Features in Pairs of bGH, bGHR and bIGF-1 Polymorphic Genes in Aberdeen-Angus Cattle

Dushayeva¹,

Наметов²,

Бейшова³

et al. 2021

OnLine Journal of Biological Sciences

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The purpose of the study is to identify paired combinations associated with meat productivity in Aberdeen-Angus cattle for the genes of the somatotropin cascade (growth hormone bGH, growth hormone receptor bGHR, insulin-like growth factor-1 bIGF-1). The determination of animal genotypes was carried out by PCR-RFLP. Results of statistical processing was carried out using the software capabilities of "Microsoft Excel 2010" and "Statistica 6.0". Paired combinations study of bGH, bGHR and bIGF-1 somatotropin cascade revealed marking diplotype polymorphic genes associated with signs of meat productivity and allowing for a comprehensive assessment of the Aberdeen-Angus cattle genetic potential in the postnatal development early stages. Thus, the animals' live weight with the bGH-AluI VV -bIGF-1-SnaBI BB diplotype at the age of 24 months exceeds the Aberdeen-Angus breed live weight standard by 45 kg (12%) and the total sample -by 12.52 kg (3%). The bGH-AluI LL -bIGF-1-SnaBI AA diplotype score is 2.93% higher than the total sample. The mass index average value of animals with the bGH-AluI LV -bGHR-SspI FY diplotype at 18 months is 3.98% lower than the total sample. In animals with the bGHR-SspI FF -bIGF-1-SnaBI BB diplotype at the age of 24 months, the churn index value is lower than the total sample by 3.74%. Thus, the diplotypes bGH-AluI VV -bIGF-1-SnaBI BB and bGH-AluI LL -bIGF-1-SnaBI AA can be considered genetic markers of increased meat productivity and the diplotypes bGH-AluI LV -bGHR-SspI FY and bGHR-SspI FF -bIGF-1-SnaBI BB -reduced meat productivity. The animals' selection with diplotypes that increase meat productivity will reduce the investment period and increase the agricultural production profitability. For breeding activities, it is recommended to maintain the animals' number with the diplotypes bGH-AluI VV -bIGF-1-SnaBI BB and bGH-AluI LL -bIGF-1-SnaBI AA .

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Comparative analysis of allele frequencies for DNA polymorphisms associated with disease and economically important traits in the genomes of Russian and foreign cattle breeds

et al. 2022

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The genetic makeup of a breed including its genetic differences from other breeds determines its appearance and characteristics, including economically important traits and resistance to pathologies. To date, many loci controlling significant phenotypes have been identified, which is successfully used in the world practice of marker-assisted selection to improve breed properties. The aim of this study was a comparative analysis of frequencies for known causative nucleotide substitutions, insertions and deletions associated with disease and economically important traits in Russian and foreign cattle breeds. As a result, we identified frequencies of these DNA polymorphisms in the populations of Russian cattle breeds, compared them with those of foreign populations of the same breed, as well as other foreign breeds. Our results indicate similarities in frequencies for most of such alleles within breeds (populations of Russian and foreign breeding), as well as the relationship between the causative allele prevalence and the presence of phenotypic traits under the effect. We also found an excess of some undesirable alleles in the Russian cattle populations, which should be paid attention to when designing breeding programs. We found that the alleles increasing fertility in the Hereford breed have a higher frequency in the Russian Hereford population compared to the foreign counterpart. Interestingly, unlike for the European breeds, for Asian Turano-Mongolian Wagyu and Yakut cattle, there was a less clear link between phenotypic traits and frequencies of known causative alleles. Our work points to specific genetic variants that could be used to improve and/or maintain the performance of certain cattle breeds bred in the Russian Federation.

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Associations between maternal milk protein genotypes with preweaning calf growth traits in beef cattle

Cited by 4 publications

References 42 publications

First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants

First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants

Marking of Meat Productivity Features in Pairs of bGH, bGHR and bIGF-1 Polymorphic Genes in Aberdeen-Angus Cattle

Comparative analysis of allele frequencies for DNA polymorphisms associated with disease and economically important traits in the genomes of Russian and foreign cattle breeds

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