Associations between interleukin-10 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis and meta-regression

Liu, Qingqing; Yang, Jin; He, Hairong; Yu, Yong; Lyu, Jun

doi:10.1007/s10067-018-4329-2

Cited by 11 publications

(4 citation statements)

References 27 publications

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“… 23 Interleukin-10-producing B cells have been suggested to be aberrant in SLE or RA. 24 , 25 Human genetic studies further supported IL-10 in controlling intestinal inflammation.…”

Section: Discussionmentioning

confidence: 98%

Associations of Gastrointestinal Tract Tumor Necrosis Factor Receptor-Associated Factor 6 Expression with Clinical Features and Prognosis of Eosinophilic Gastroenteritis

Bai¹,

Tang²,

Zhu³

et al. 2023

Turk J Gastroenterol

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Background: Few studies have been conducted to explore the expression of tumor necrosis factor receptor-associated factor 6 in eosinophilic gastroenteritis patients. Therefore, the expression profile of tumor necrosis factor receptor-associated factor 6 in the gastrointestinal tract of eosinophilic gastroenteritis patients and its associations with clinical features were explored in this study. Methods: Thirty-four eosinophilic gastroenteritis patients who presented in Ruijin Hospital from December 2012 to May 2019 and had accepted gastrointestinal endoscopic examinations were recruited. Medical records and endoscopic biopsies were collected, and the prognosis was followed up by telephone. Healthy persons were selected as the control group. Hematoxylin and eosin and immunohistochemical staining were performed in both eosinophilic gastroenteritis patients and healthy persons. The final results were analyzed by skilled pathologists, and mean optical density values of tumor necrosis factor receptor-associated factor 6 were calculated by Image J software. Final results were analyzed by Statistical Package for the Social Sciences software 22.0. Results: Thirty-four patients (mean age: 25.56 ± 21.14 years, 61.76% males) were recruited for this study. There was no significant difference in tumor necrosis factor receptor-associated factor 6 mean optical density values of gastric tissues in eosinophilic gastroenteritis patients and healthy people (0.22 ± 0.16 vs. 0.14 ± 0.05, P > .05). Eosinophilic gastroenteritis patients had a significantly lower level of intestinal tumor necrosis factor receptor-associated factor 6 mean optical density values than that of healthy people (0.16 ± 0.05 vs. 0.23 ± 0.06, P < .05). Intestinal tumor necrosis factor receptor-associated factor 6 mean optical density values negatively linearly correlated with serum interleukin-10 level ( r = −0.618, P = .043 < .05). There were no differences between eosinophilic gastroenteritis patients with or without relapse regarding the expression level of intestinal tumor necrosis factor receptor-associated factor 6 ( P = .227 > .05). Conclusion: Patients with eosinophilic gastroenteritis might have a deficiency of intestinal tumor necrosis factor receptor-associated factor 6 compared to healthy controls.

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“… 23 Interleukin-10-producing B cells have been suggested to be aberrant in SLE or RA. 24 , 25 Human genetic studies further supported IL-10 in controlling intestinal inflammation.…”

Section: Discussionmentioning

confidence: 98%

Associations of Gastrointestinal Tract Tumor Necrosis Factor Receptor-Associated Factor 6 Expression with Clinical Features and Prognosis of Eosinophilic Gastroenteritis

Bai¹,

Tang²,

Zhu³

et al. 2023

Turk J Gastroenterol

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“…In a Chinese population, RA patients had a substantial drop in the frequency of an allele (A) in rs1800890 of IL-10, indicating that the A allele may be protective against RA. 35 . The association between IL-10 polymorphisms and RA risk was shown to be more significant in Caucasians than in Asians in meta-analysis research.…”

Section: Discussionmentioning

confidence: 99%

Study of pathological and biochemical connection of IL-10 gene polymorphism and Rheumatoid Arthritis and Atopic Dermatitis in Egyptian patients admitted in local clinical setting

Atallah

Solyman

Ahmed

et al. 2023

Azhar International Journal of Pharmaceutical and Medical Scien

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Rheumatoid arthritis (RA) is a chronic inflammation of the immune system that similarly affects the synovial joints. Atopic dermatitis (AD) is a chronic skin condition that is characterized by a complicated interaction of repeated exposures, host factors, and hereditary factors. Interleukin 10 (IL-10) is an immuneregulatory cytokine that is commonly utilized in RA to reduce the inflammatory response. An allelic variation in the IL-10 gene's promoter region may play a role in autoantibody production control. This study aims to identify Polymorphisms in the IL-10 gene in RA and AD patients and sequence the IL-10 gene fragment to elucidate the polymorphism (IL10-1082A/G) and determine the possible relationship between IL10 gene polymorphism and pathogenesis of RA and AD. Twenty-five blood samples were collected from RA Egyptian patients / 17 healthy control samples and 19 blood samples were collected from AD Egyptian patients / 12 healthy control. DNA has been extracted from blood samples and subjected to a Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) test for the determination of the IL-10 genotype. PCR products were sent for sequencing. Genotyping revealed that both the patient and control groups had the same IL-10 allele sequencing results and showed silent mutation with no effect in the amino acid sequence. Our results showed that there is no association between IL10-1082 A/G single nucleotide polymorphism (SNP) and RA or AD pathogenesis. Environmental factors may have more effect on the pathogenesis of RA and AD.

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“…In this study, RA patients with IL-10 -592AA and −592CA genotypes showed lower levels of IL-10 protein. 62 In addition, IL-10 has dual effects in the pathogenesis of RA. Although IL-10 down regulates the pro-inflammatory cytokines TNF-α and IL-6, it also enhances autoantibody production by B cells stimulation.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

Yousefi

Mirsanei

Bitaraf

et al. 2022

Int J Immunopathol Pharmacol

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Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that is identified with chronic inflammation and progressive destruction of the joints. The defective activity of regulatory T cells (Tregs) plays a crucial role in RA development. Oleuropein (OLEU) is the most common polyphenolic compound in olive leaf extracts with numerous pharmacological activities. In this study, the potential effects of OLEU in shifting CD4+ T cells toward Tregs are evaluated in patients with RA. Methods 32 healthy controls (HC) and 45 RA patients were included in two groups. The immunoturbidometric technique was used to measure serum levels of c-reactive protein (CRP) and rheumatoid factor (RF). Isolated CD4+ T cells from peripheral blood mononuclear cells (PBMCs) of HC and RA patients were cultured with appropriate concentrations of OLEU. The cytotoxicity effects of OLEU were determined using the MTT assay at 24, 48, and 72 h. The percentage of CD4+CD25 + FoxP3 regulatory T lymphocytes (Tregs) and the expressions of IL-10 and TGF-β were evaluated by flow cytometry and immunoassay techniques after treatment of cells with different concentrations of OLEU for 24 h. The serum levels of RF and CRP in patients with RA were 11.8 ± 5.32 IU/ml and 6.36 ± 5.82 mg/l, respectively. Results OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs ( p = 0.0001). Moreover, it induced the production of IL-10 ( p = 0.0001) and TGF-β ( p < 0.01) in both HC and RA patients. Conclusion The findings of this study suggest that OLEU may have immunomodulatory effects by inducing Tregs, and it might help in developing a novel nutrition strategy for management of autoimmune diseases such as RA.

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Associations between interleukin-10 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis and meta-regression

Cited by 11 publications

References 27 publications

Associations of Gastrointestinal Tract Tumor Necrosis Factor Receptor-Associated Factor 6 Expression with Clinical Features and Prognosis of Eosinophilic Gastroenteritis

Associations of Gastrointestinal Tract Tumor Necrosis Factor Receptor-Associated Factor 6 Expression with Clinical Features and Prognosis of Eosinophilic Gastroenteritis

Study of pathological and biochemical connection of IL-10 gene polymorphism and Rheumatoid Arthritis and Atopic Dermatitis in Egyptian patients admitted in local clinical setting

Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

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