Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

Yousefi, Zahra; Mirsanei, Zahra; Bitaraf, Fatemeh Sadat; Mahdavi, Sepideh; Mirzaii, Mehdi; Jafari, Reza

doi:10.1177/03946320221086084

Cited by 10 publications

(11 citation statements)

References 72 publications

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“…Given that increase the incidence rate of men with prostate cancer, it is crucial to find new strategies for managing or treating of this disease. Today, some dietary recommendations have been made to treat various conditions like cancer, such as nutrition and leading a better lifestyle, but the results and advice are not yet useful (9,10).…”

Section: Introductionmentioning

confidence: 99%

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

et al. 2023

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Cancer is caused by abnormal proliferation of cells and aberrant recognition of the immune system. According to recent studies, natural products are most likely to be effective at preventing cancer without causing any noticeable complications. Among the bioactive flavonoids found in fruits and vegetables, quercetin is known for its anti-inflammatory, antioxidant, and anticancer properties. This review aims to highlight the potential therapeutic effects of quercetin on some different types of cancers including blood, lung and prostate cancers.

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Section: Introductionmentioning

confidence: 99%

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

et al. 2023

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“…OLE does not alter cell viability of RAW264.7 and J774A.1 murine cells at concentrations ranging from 5 to 80 μM [ 72 , 73 ] or even higher (100–400 μg/mL) [ 74 ]. Similarly, 25–200 μg/mL OLE left human CD4+ cell viability unaltered [ 75 ], and human polymorphonuclear cells were unharmed by 320 μg/mL OLE [ 49 ]. Moreover, OLE concentrations in the nM and μM ranges improve PBMC viability after γ-irradiation [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis

Pojero

Gervasi

Fiore

et al. 2023

IJMS

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Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subjects: Adult (age 18–64 years) and Senior (age ≥ 65 years). OLE and HT were used alone or as a pre-treatment before challenging PBMCs with lipopolysaccharide (LPS). Both polyphenols had no effect on cell viability irrespective of LPS, but 5 µM HT had an LPS-like effect on monocytes, reducing the intermediate subset in Adult subjects. OLE and HT had no effect on LPS-triggered release of TNF-α, IL-6 and IL-8, but 5 µM HT reduced IL-10 secretion by PBMCs from Adult vs. Senior group. In summary, nutritionally relevant concentrations of OLE and HT elicit no anti-inflammatory effect and influence the frequency of immune cell subsets with age-related different outcomes.

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“…Correlation Analysis of miR-124a in Peripheral Blood Plasma, PBMCs, and Synovial Fluid with Major Clinical Indicators in RA Patients Existing evidence has shown that RF, ESR, and DAS28 are commonly used activity indicators for monitoring RA in clinical practice [2,18,22,23]. Hence, Pearson analysis was used to further investigate the correlation between miR-124a expression levels in peripheral blood plasma, PBMCs, and synovial fluid with RF, ESR, and DAS28.…”

Section: Down-regulation Of Mir-124a In Peripheral Bloodmentioning

confidence: 99%

The Diagnostic Value of miR-124a Expression in Peripheral Blood and Synovial Fluid of Patients with Rheumatoid Arthritis

Wu¹,

Zhang²,

Peng³

et al. 2023

Hum Hered

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Introduction: Rheumatoid arthritis (RA), a chronic autoimmune disorder, is currently a severe health threat. Previous studies have documented the altered expression of various miRNAs in RA patients. This study determined the expression of miR-124a in RA patients and estimated its diagnostic value for RA. Methods: Total 80 RA patients were enrolled as the study subjects and 36 patients with osteoarthritis were included, with another 36 healthy people as the controls. miR-124a expression levels in peripheral blood plasma, peripheral blood mononuclear cells (PBMCs), and synovial fluid were measured using RT-qPCR, followed by Pearson correlation analysis. Additionally, the association between miR-124a and major clinical indicators was assessed, such as rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), and disease activity score of 28 joints (DAS28). The diagnostic efficacy of miR-124a expression in plasma, PBMCs, and synovial fluid for RA was evaluated by the receiver operating characteristic (ROC) curve, and the difference in the area under the curve (AUC) was analyzed. Results: miR-124a was downregulated in RA patients and the expression levels of miR-124a in plasma, PBMCs, and synovial fluid showed a certain degree of positive correlation. miR-124a was inversely linked with RF, ESR, and DAS28. For the diagnosis of RA patients, the AUC of plasma miR-124a was 0.899 and the cut-off value was 0.800, with 68.75% sensitivity and 94.44% specificity; the AUC of miR-124a in PBMCs was 0.937, and the cut-off value was 0.805, with 82.50% sensitivity and 91.67% specificity; the AUC of miR-124a in plasma combined with PBMCs was 0.961, with a higher diagnostic value than independent plasma or PBMCs; the AUC of miR-124a in synovial fluid was 0.929, and the cut-off value was 0.835, with 80.00% sensitivity and 88.89% specificity. Conclusion: miR-124a expression is downregulated in plasma, PBMCs, and synovial fluid of RA patients and has a high diagnostic value for RA.

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Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

Cited by 10 publications

References 72 publications

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis

The Diagnostic Value of miR-124a Expression in Peripheral Blood and Synovial Fluid of Patients with Rheumatoid Arthritis

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