The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

Lotfi, Noushin; Yousefi, Zahra; Golabi, Marjan; Khalilian, Parvin; Ghezelbash, Behrooz; Montazeri, Mina; Shams, Mohammad H.; Baghbadorani, Parnian Zolfaghari; Eskandari, Nahid

doi:10.3389/fimmu.2023.1077531

Cited by 31 publications

(10 citation statements)

References 174 publications

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“…through the Akt/mTOR/P70S6K signaling pathway 25 . Emodin, which is another selected compound based on in silico experiments, inhibits cancer growth by suppressing the expression of MMP7, MMP9, VEGF, EMT, N-cadherin, b-catenin, and Snail based on literature data.…”

Section: Studies Have Shown That Another Compound Quercetin Reduces T...mentioning

confidence: 99%

5-Fluorouracil and Rumex obtusifolius extract combination trigger A549 cancer cell apoptosis: Uncovering PI3K/Akt inhibition by in vitro and in silico approaches

Ginovyan,

Javrushyan,

Hovhannisyan

et al. 2024

Preprint

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In this study, the objective was to explore novel strategies for improving the efficacy of anticancer therapy. The focus was on investigating the antiproliferative effects of combining Rumex obtusifolius extract (RO) with the chemotherapeutic agent 5-Fluorouracil (5-FU) in non-small A549 lung cancer cells (NSCLC). Key factors such as the PI3K/Akt cell signaling system, cytokines, growth factors (TNFa, VEGFa), and enzymes (Arginase, NOS, COX-2, MMP-2) were analyzed to assess the impact of the combination treatment. Results revealed that the combined treatment of 5-FU and RO demonstrated a significant reduction in TNFa levels, comparable to the effect observed with RO alone. RO was found to modulate the PI3K/Akt pathway, influencing the phosphorylated and total amounts of these proteins during the combined treatment. Notably, COX-2, a key player in inflammatory processes, substantially decreased with the combination treatment. Caspase-3 activity, indicative of apoptosis, increased by 1.8 times in the combined treatment compared to separate treatments. In addition, in silico analyses explored the binding affinities and interactions of RO's major phytochemicals with intracellular targets, revealing a high affinity for PI3K and Akt. These findings suggest that the combined treatment induces apoptosis in A549 cells by regulating the PI3K/Akt pathway.

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Section: Studies Have Shown That Another Compound Quercetin Reduces T...mentioning

confidence: 99%

5-Fluorouracil and Rumex obtusifolius extract combination trigger A549 cancer cell apoptosis: Uncovering PI3K/Akt inhibition by in vitro and in silico approaches

Ginovyan,

Javrushyan,

Hovhannisyan

et al. 2024

Preprint

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“…Several studies describe quercetin as a unique compound for its high potential to fight cancer-related diseases in many ways. Different concentrations have been evaluated, proving that this bioactive compound suppresses tumor growth of various cancer cell lines, including breast, colorectal, cervical, and lung, among others [ 43 ].…”

Section: Overview Of Polyphenols and Their Anticancer Propertiesmentioning

confidence: 99%

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Vieira,

Tessaro,

Lima

et al. 2023

Nutrients

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Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative nanotechnologies have been applied to encapsulate these compounds, aiming to improve their efficacy against cancer. In this comprehensive review, we evaluate the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer using in vitro studies and in vivo preclinical models, highlighting recent advancements in the field. It was found that polymeric nanomaterials, lipid-based nanomaterials, inorganic nanomaterials, and carbon-based nanomaterials are the most used classes of nanocarriers for encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity and pro-apoptotic effects, particularly against breast, lung, prostate, cervical, and colorectal cancer cells, surpassing the performance of free bioactive compounds. Preclinical trials in xenograft animal models have revealed decreased tumor growth after treatment with polyphenol-loaded delivery systems. Moreover, the interaction of polyphenol co-delivery systems and polyphenol–drug delivery systems is a promising approach to increase anticancer activity and decrease chemotherapy side effects. These innovative approaches hold significant implications for the advancement of clinical cancer research.

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“…Firstly discovered in the early 20th century, quercetin is a widely studied flavonoid with numerous health benefits. Over the years, several studies have demonstrated its protective role in liver diseases (Lotfi et al, 2023; Terao, 2023).…”

Section: Mechanisms Of Polyphenolic Compounds Protect Against Hepatic...mentioning

confidence: 99%

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Hu,

Zhang,

Wei

et al. 2023

Phytotherapy Research

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This review focuses on the potential ameliorative effects of polyphenolic compounds derived from human diet on hepatic diseases. It discusses the molecular mechanisms and recent advancements in clinical applications. Edible polyphenols have been found to play a therapeutic role, particularly in liver injury, liver fibrosis, NAFLD/NASH, and HCC. In the regulation of liver injury, polyphenols exhibit anti‐inflammatory and antioxidant effects, primarily targeting the TGF‐β, NF‐κB/TLR4, PI3K/AKT, and Nrf2/HO‐1 signaling pathways. In the regulation of liver fibrosis, polyphenolic compounds effectively reverse the fibrotic process by inhibiting the activation of hepatic stellate cells (HSC). Furthermore, polyphenolic compounds show efficacy against NAFLD/NASH by inhibiting lipid oxidation and accumulation, mediated through the AMPK, SIRT, and PPARγ pathways. Moreover, several polyphenolic compounds exhibit anti‐HCC activity by suppressing tumor cell proliferation and metastasis. This inhibition primarily involves blocking Akt and Wnt signaling, as well as inhibiting the epithelial‐mesenchymal transition (EMT). Additionally, clinical trials and nutritional evidence support the notion that certain polyphenols can improve liver disease and associated metabolic disorders. However, further fundamental research and clinical trials are warranted to validate the efficacy of dietary polyphenols.

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The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

Cited by 31 publications

References 174 publications

5-Fluorouracil and Rumex obtusifolius extract combination trigger A549 cancer cell apoptosis: Uncovering PI3K/Akt inhibition by in vitro and in silico approaches

5-Fluorouracil and Rumex obtusifolius extract combination trigger A549 cancer cell apoptosis: Uncovering PI3K/Akt inhibition by in vitro and in silico approaches

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

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