Associations between hair levels of trace elements and the risk of preterm birth among pregnant women: A prospective nested case-control study in Beijing Birth Cohort (BBC), China

Ren, Mengyuan; Jing, Zhao; Wang, Bin; An, Hang; Li, Yuhuan; Jia, Xiaoqian; Wang, Jiamei; Wang, Shuo; Yan, Lailai; Liu, Xiaohong; Pan, Bo; Li, Zhiwen; Ye, Rongwei

doi:10.1016/j.envint.2021.106965

Cited by 29 publications

(26 citation statements)

References 76 publications

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“…Some scholars proposed that trace elements may play a vital role in developing preeclampsia ( 3 – 5 ). In spite of making up <0.1% in the human body, trace elements have a disproportional function in maintaining health.…”

Section: Introductionmentioning

confidence: 99%

“…A significant lower levels of Zn may cause a series of dysfunctions in the biological process and higher risks of developing feto-maternal complications, such as gestational diabetes, preterm pre-labor rupture of membrane (PPROM), preterm birth, and low birth weight. The relationship between maternal serum Zn and preeclampsia were studied as micronutrients imbalance is believed a contributing factor of preeclampsia ( 3 , 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite many researchers devoted to this field, the etiology of preeclampsia is still largely unknown. Some scholars proposed that trace elements may play a vital role in developing preeclampsia (3)(4)(5). In spite of making up <0.1% in the human body, trace elements have a disproportional function in maintaining health.…”

Section: Introductionmentioning

confidence: 99%

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Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Jin

Zheng

2022

Front. Public Health

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BackgroundPreeclampsia (PE) is a multi-organ syndrome that onsets in the second half of pregnancy. It is the second leading cause of maternal death globally. The homeostasis of zinc (Zn) levels is important for feto-maternal health.ObjectiveWe aimed to collect all studies available to synthesize the evidence regarding the association between maternal Zn levels and the risk of preeclampsia.MethodsA systematic review and meta-analysis was conducted via searching seven electronic databases [PubMed, Web of Science, Embase, African Journals Online (AJOL), ClinicalTrial.gov, and two Chinese databases: Wanfang and Chinese National Knowledge Infrastructure, CNKI]. Studies reporting maternal serum Zn levels in pregnant women with or without preeclampsia were included. Eligible studies were assessed through Newcastle-Ottawa Scale (NOS) and the meta-analysis was performed via RevMan and Stata. The random-effects method (REM) was used for the meta-analysis with 95% confidence interval (CI). The pooled result was assessed using standard mean difference (SMD). The heterogeneity test was carried out using I2 statistics, and the publication bias was evaluated using Begg's and Egger's test. Meta-regression and sensitivity analysis was performed via Stata software.ResultsA total of 51 studies were included in the final analysis. 6,947 participants from 23 countries were involved in our study. All studies went through the quality assessment. The pooled results showed that maternal serum Zn levels were lower in preeclamptic women than in healthy pregnant women (SMD: −1.00, 95% CI: −1.29, −0.70). Sub-group analysis revealed that geographical, economic context, and disease severity may further influence serum Zn levels and preeclampsia.LimitationsThere are significant between-study heterogeneity and publication bias among included studies.ConclusionsA lower level of maternal Zn was associated with increased risks of preeclampsia. The associations were not entirely consistent across countries and regions worldwide.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=337069, Identifier: CRD42022337069

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Jin

Zheng

2022

Front. Public Health

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“…Our pilot study only chose the two typical classes of chemicals associated with the SPB or gestational week to construct the prediction model due to limited experimental expenses, i.e., elements ,, and PFASs. , Various biomarkers of exposure and effects were detected with high detection rates in maternal blood samples, including elements (42), PFASs (3), immune biomarkers (8) of inflammatory cytokine, oxidative stress damage, DNA adducts, and lipidomic features (1028), resulting in 1081 exposure features. Detailed information on the individual chemicals and analytical methods is provided in Table S2 and Section S2.…”

Section: Methodsmentioning

confidence: 99%

Using Machine Learning to Expedite the Screening of Environmental Factors Associated with the Risk of Spontaneous Preterm Birth: From Exposure Mixtures to Key Molecular Events

Feng

Lin

et al. 2023

Environ. Sci. Technol. Lett.

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Spontaneous preterm birth (SPB) is affected by various environmental exposures. However, there is still an urgent need to efficiently integrate exposomic information to build its prediction model and unveil the potential toxic pathways. Here, we conducted a nested case-control study by recruiting 30 women with SPB delivery (cases) and 30 women without (controls) at their early pregnancy. We analyzed various biomarkers of external chemical exposure, lipidomics, and immunity, resulting in 1081 exposure features. A logistic regression model (LR) was used to screen potential risk factors, and four statistical learners were used to establish SPB prediction models. Overall, the serum lipid concentration in cases was higher than in controls, while this was not the case for chemical and immune biomarkers. Random forest (RF) and extreme gradient boosting (XGboost) models had a relatively higher prediction accuracy of > 90%. Glycerophospholipids (GP) were the most abundant lipidomic features screened by LR, RF, and XGboost models, followed by glycerolipids and sphingolipids, shown as well as by enrichment analysis. Moreover, FA(21:0) had the largest contribution to the prediction performance. Maternal exposure to various elements can contribute to SPB risk due to their interaction with GP metabolism. Therefore, it is promising to use exposomic data to predict SPB risk and screen key molecular events.

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“…Its deficiency is associated with diabetes and dyslipidemia, while its excessive storage could lead to tumorigenesis (7,8). In pregnancy, aberrant maternal copper levels may lead to early spontaneous miscarriage, fetal structural anomalies, gestational diabetes, small-for-gestation babies, and preterm birth (9)(10)(11). However, its role in the development of PE seems controversial.…”

Section: Introductionmentioning

confidence: 99%

A Global Perspective of Correlation Between Maternal Copper Levels and Preeclampsia in the 21st Century: A Systematic Review and Meta-Analysis

Zhong

Yang

Sun

et al. 2022

Front. Public Health

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Background:Preeclampsia (PE) is a common multi-system disorder in pregnancy and a major cause of maternal and perinatal morbidity and mortality globally. Copper is a crucial micronutrient for human health.MethodsA systematic review was performed according to Preferred Reporting Item for Systematic Reviews and Meta-analysis (PRISMA) guidelines to synthesize the best available evidence regarding the correlation between maternal copper levels and PE from women with different geographical and economic backgrounds.ResultsA total of 34 studies containing 2,471 women with PE and 2,888 healthy pregnant controls across 16 countries were included for research. All studies were systematically reviewed and assessed with the Newcastle-Ottawa Scale (NOS), The Agency of Healthcare for Research and Quality (AHRQ) assessment tools according to the study types. Globally, there was no significant difference in maternal serum copper levels between women with PE and control (Mean difference 5.46, 95% CI −9.63, 20.54). Sub-group analysis from geographical and economic perspectives revealed contrasting results. In conclusion, copper is associated with PE, but the levels of copper leading to increased risk of PE varied across regions and economic development.ConclusionsThe deranged maternal copper levels are correlated with risks of PE, but it presents variously across different geographical and economic contexts.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=306536. Identifier: CRD42022306536.

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Associations between hair levels of trace elements and the risk of preterm birth among pregnant women: A prospective nested case-control study in Beijing Birth Cohort (BBC), China

Cited by 29 publications

References 76 publications

Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Using Machine Learning to Expedite the Screening of Environmental Factors Associated with the Risk of Spontaneous Preterm Birth: From Exposure Mixtures to Key Molecular Events

A Global Perspective of Correlation Between Maternal Copper Levels and Preeclampsia in the 21st Century: A Systematic Review and Meta-Analysis

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