Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Jin, Senjun; Hu, Chaozhou; Zheng, Yanyan

doi:10.3389/fpubh.2022.968045

Cited by 16 publications

(17 citation statements)

References 81 publications

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“…9 In addition, there were significant differences in zinc level between pregnant women with preeclampsia and control (0.77 ± 0.05 mg/dL versus 0.98 ± 0.03 mg/dL; p = 0.000). 22 In this study, there was lower zinc level compared with other studies. The difference could be caused by the study samples taken at 28-42 weeks of gestation.…”

Section: P-value Pe Yes Nocontrasting

confidence: 44%

Level of maternal zinc serum as risk factor of preeclampsia

Kaprianti¹,

Mirani²,

Martadiansyah³

et al. 2022

Indones J Obstet Gynecol

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Objective : To know the relationship of serum zinc levels with preeclampsia (PE) Method: This observational research uses a type of case control research. The population of this study is all pregnant women with a single pregnancy, gestational age of 28-42 weeks who were treated at the Department of Obstetrics and Gynecology of RSUP Dr. Mohammad Hoesin Palembang from August 2020 to November 2020. The study divided into 2 group, a case group of 30 pregnant women with PE and a control group of 60 pregnant women non PE. Serum zinc level examination is performed on all samples that match the research criteria. The data is processed by using SPSS software program version 20.0 Windows. Result: Both case and control groups had no meaningful differences to the general characteristics of the patient. There were significant differences in average zinc levels of maternal serum in both research groups (p=0.013; 43.90 plus-minus 15.79 pg/dL). The value of serum zinc levels that have the best sensitivity and specificity is at 45.5 pg/dL. Conclusion: There is a meaningful relationship between serum zinc levels and PE events. Pregnant women with serum zinc levels greater than or equal to 45.5 pg /dL were significantly at 3.2 times more risk of PE than pregnant women with serum zinc levels less than or equal to 45.5 pg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia. Keywords: preeclampsia, zinc, case-control studies

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Section: P-value Pe Yes Nocontrasting

confidence: 44%

Level of maternal zinc serum as risk factor of preeclampsia

Kaprianti¹,

Mirani²,

Martadiansyah³

et al. 2022

Indones J Obstet Gynecol

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“…Women with pre-eclampsia had lower zinc concentrations compared to healthy pregnant controls (SMD -0.587, 95%CI: -0.963 to -0.212, 1091 participants, 14 studies, I 2 88%), measured largely in the third trimester (36). Significantly lower zinc concentrations among pre-eclamptic women compared to healthy controls were only found in Asia (36,74,75) and sub-Saharan Africa (76), not in other regions of the world.…”

Section: Definite Associationsmentioning

confidence: 95%

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

et al. 2022

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Pre-eclampsia is a serious complication of pregnancy, and maternal nutritional factors may play protective roles or exacerbate risk. The tendency to focus on single nutrients as a risk factor obscures the complexity of possible interactions, which may be important given the complex nature of pre-eclampsia. An evidence review was conducted to compile definite, probable, possible and indirect nutritional determinants of pre-eclampsia to map a nutritional conceptual framework for pre-eclampsia prevention. Determinants of pre-eclampsia were first compiled through an initial consultation with experts. Secondly, an expanded literature review was conducted to confirm associations, elicit additional indicators and evaluate evidence. The strength of association was evaluated as definite RR<0.40 or ≥3.00, probable RR 0.40-0.69 or 1.50-2.99, possible RR 0.70-0.89 or 1.10-1.49 or not discernible RR 0.90-1.09. The quality of evidence was evaluated using GRADE. Twenty-five nutritional factors were reported in two umbrella reviews and 22 meta-analyses. Of these, 14 were significantly associated with pre-eclampsia incidence. Maternal vitamin D deficiency and higher serum iron emerged as definite nutritional risk factors for pre-eclampsia incidence across populations, while low serum zinc was a risk factor in Asia and Africa. Calcium and/or vitamin D supplementation were probable protective nutritional factors. Healthy maternal dietary patterns were possibly associated with lower risk of developing pre-eclampsia. Potential indirect pathways of maternal nutritional factors and pre-eclampsia may exist through obesity, maternal anaemia and gestational diabetes mellitus. Research gaps remain on the influence of household capacities and sociocultural, economic and political contexts, as well as interactions with medical conditions.

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“…For eclampsia at any gestational age, aggressive early delivery is advised when the mother and fetus have stabilized. If the mother and fetus are stable, vaginal birth with an IV oxytocin infusion should be tried [ 14 - 16 ].…”

Section: Reviewmentioning

confidence: 99%

Eclampsia and Its Treatment Modalities: A Review Article

Akre¹,

Sharma²,

Chakole³

et al. 2022

Cureus

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Hypertension in pregnancy is one of the major contributors to mortality and morbidity. Pregnant women and fetuses are both at high risk of the severe complications of preeclampsia known as eclampsia. Eclampsia is a disorder that requires immediate detection and treatment. Eclampsia and preeclampsia during pregnancy are known to cause morbidity and even death in both the mother and fetus if not properly diagnosed. Chronic hypertension, prenatal hypertension, preeclampsia on top of chronic hypertension, and eclampsia are the four types of hypertension. Preeclampsia is the precursor to eclampsia. Associated with end-organ failure and proteinuria after 20 weeks of pregnancy, preeclampsia is characterized by the development of hypertension with systolic blood pressure (BP) of at least 140 mmHg and/or diastolic BP of at least 90 mmHg. It can lead to the failure of the liver, thrombocytopenia, pulmonary edema, central nervous system (CNS) abnormalities, and renal dysfunction. The emergence of new generalized tonic-clonic seizures in a pregnant woman with preeclampsia is known as eclampsia. Eclamptic seizures can happen prior to delivery, 20 weeks following conception, during delivery, and after delivery. Although rare, gestational trophoblastic illness has been associated with seizures that start before 20 weeks. In this article, we examine the pathogenesis, causes, signs, symptoms, and treatment modalities in patients with eclampsia.

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Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Cited by 16 publications

References 81 publications

Level of maternal zinc serum as risk factor of preeclampsia

Level of maternal zinc serum as risk factor of preeclampsia

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

Eclampsia and Its Treatment Modalities: A Review Article

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