Using Machine Learning to Expedite the Screening of Environmental Factors Associated with the Risk of Spontaneous Preterm Birth: From Exposure Mixtures to Key Molecular Events
Abstract:Spontaneous preterm birth (SPB) is affected by various
environmental
exposures. However, there is still an urgent need to efficiently integrate
exposomic information to build its prediction model and unveil the
potential toxic pathways. Here, we conducted a nested case-control
study by recruiting 30 women with SPB delivery (cases) and 30 women
without (controls) at their early pregnancy. We analyzed various biomarkers
of external chemical exposure, lipidomics, and immunity, resulting
in 1081 exposure features.… Show more
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