Associations between Dietary Antioxidant Intake and Metabolic Syndrome

Abstract

BackgroundThe objective of this study was to evaluate the association between dietary antioxidant intake (carotenoid, vitamin C, E and selenium) intake and metabolic syndrome (MS).MethodThis cross-sectional study included 2069 subjects undergoing a regular health checkup. Biochemical test results and data on dietary intakes were collected for analysis. Adjustment for energy intake and multi-variable logistic regression were performed to determine adjusted odds ratios (ORs) and corresponding 95% confidence intervals (95%CI) for the relationship between dietary antioxidants intake and MS. The lowest quartile of antioxidant intake was regarded as the reference category.ResultDietary vitamin C intake (P values for trend were 0.02 in energy adjusted analysis and 0.08 in multivariable adjusted analysis) had a negative association with MS, as did selenium intake in the second quartile (energy adjusted OR: 0.60, 95%CI: 0.43 to 0.85; multivariable adjusted OR: 0.60, 95%CI: 0.43 to 0.86). However, there was no significant relationship between dietary carotenoid and vitamin E intake and MS.ConclusionSubjects with low intake of vitamin C might be predisposed to development of MS, while dietary selenium intake had a moderate negative association with MS. Dietary carotenoid and vitamin E intake was not associated with MS.

Inadequacies in the habitual nutrient intakes of patients with metabolic syndrome: a cross-sectional study

“…However, findings regarding the association between antioxidant intake and the development of MS remain inconsistent. Wei et al [13] and Motamed et al [49] did not observe a significant association between the intake of vitamins A and E and the development of MS.…”

“…Therefore, the adequate dietary ingestion of antioxidant micronutrients such as vitamins A, C and E, selenium and zinc minerals, may be a protective factor to prevent tissue damage arising from oxidative stress [12, 13]. Puchau et al showed that the dietary total antioxidant capacity may provide an estimation of the risk of development of MS components [48].…”

“…As an antioxidant, selenium protects against the damage caused by oxidative stress because of the functions of selenoproteins. In an adult population, the dietary intake of selenium showed moderate association with MS in the second quartile of distribution [13]. Plasma selenium levels were correlated positively with all the components of MS in Lebanese adults [51].…”

“…Saturated fat intake greater than 10 % of the total caloric value indicated a risk for MS in Brazilian adults [11]. Low intake of antioxidant nutrients such as vitamin C, selenium, and zinc might also predispose the development of MS [12, 13]. Negative significant correlation coefficients were observed among dietary fat, energy, protein intake, and serum antioxidant state.…”

Metabolic syndrome and selenium in fetal programming: gender differences

“…1 Se status has therefore been related to different diseases, including metabolic syndrome (MS), 2 which is a pathological state defined as a cluster of risk factors, including central obesity, insulin resistance (IR), raised blood pressure and dyslipidemia, which may predispose an individual to cardiovascular diseases, diabetes and death. 6 However, a dual role for Se in IR and MS has been described. 5 Therefore, it could be supposed that dietary Se supplementation could have beneficial antioxidant effects in this pathology, increasing GPx activity.…”